| # | Title | Journal | Year | Citations |
|---|
| 1 | Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro | Cell Discovery | 2020 | 1,643 |
| 2 | Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2 | Cell Discovery | 2020 | 1,258 |
| 3 | CRISPR-Cas12a-assisted nucleic acid detection | Cell Discovery | 2018 | 805 |
| 4 | Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations | Cell Discovery | 2020 | 717 |
| 5 | Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing | Cell Discovery | 2020 | 644 |
| 6 | VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation | Cell Discovery | 2018 | 643 |
| 7 | Bi-directional differentiation of single bronchioalveolar stem cells during lung repair | Cell Discovery | 2020 | 587 |
| 8 | Inflammasome activation and regulation: toward a better understanding of complex mechanisms | Cell Discovery | 2020 | 475 |
| 9 | Lysosome biology in autophagy | Cell Discovery | 2020 | 420 |
| 10 | Phase-adjusted estimation of the number of Coronavirus Disease 2019 cases in Wuhan, China | Cell Discovery | 2020 | 358 |
| 11 | Efficient genome editing in filamentous fungus Trichoderma reesei using the CRISPR/Cas9 system | Cell Discovery | 2015 | 356 |
| 12 | A CRISPR-based approach for targeted DNA demethylation | Cell Discovery | 2016 | 325 |
| 13 | The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro | Cell Discovery | 2020 | 249 |
| 14 | Sulfated polysaccharides effectively inhibit SARS-CoV-2 in vitro | Cell Discovery | 2020 | 246 |
| 15 | Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity | Cell Discovery | 2016 | 239 |
| 16 | The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing | Cell Discovery | 2020 | 188 |
| 17 | SARS-CoV-2 detection with CRISPR diagnostics | Cell Discovery | 2020 | 188 |
| 18 | Repurposing CRISPR-Cas12b for mammalian genome engineering | Cell Discovery | 2018 | 183 |
| 19 | Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro | Cell Discovery | 2020 | 172 |
| 20 | Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro | Cell Discovery | 2017 | 166 |
| 21 | Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing | Cell Discovery | 2016 | 165 |
| 22 | SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2 | Cell Discovery | 2020 | 165 |
| 23 | Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility | Cell Discovery | 2020 | 159 |
| 24 | Single-cell profiling of the human decidual immune microenvironment in patients with recurrent pregnancy loss | Cell Discovery | 2021 | 152 |
| 25 | Multiplex gene regulation by CRISPR-ddCpf1 | Cell Discovery | 2017 | 151 |
| 26 | The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes | Cell Discovery | 2021 | 151 |
| 27 | Emerging roles of ATG proteins and membrane lipids in autophagosome formation | Cell Discovery | 2020 | 149 |
| 28 | SARS-CoV-2 cell tropism and multiorgan infection | Cell Discovery | 2021 | 148 |
| 29 | Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade | Cell Discovery | 2017 | 147 |
| 30 | Efficient generation of mouse models with the prime editing system | Cell Discovery | 2020 | 146 |
| 31 | Single-cell RNA sequencing reveals the heterogeneity of liver-resident immune cells in human | Cell Discovery | 2020 | 137 |
| 32 | Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2 | Cell Discovery | 2020 | 132 |
| 33 | Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface | Cell Discovery | 2017 | 130 |
| 34 | Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry | Cell Discovery | 2018 | 128 |
| 35 | Synthesizing ginsenoside Rh2 in Saccharomyces cerevisiae cell factory at high-efficiency | Cell Discovery | 2019 | 114 |
| 36 | Activation and targeting of ATG8 protein lipidation | Cell Discovery | 2020 | 111 |
| 37 | Single-copy sensitive, field-deployable, and simultaneous dual-gene detection of SARS-CoV-2 RNA via modified RT–RPA | Cell Discovery | 2020 | 109 |
| 38 | Single-cell analysis of pancreatic ductal adenocarcinoma identifies a novel fibroblast subtype associated with poor prognosis but better immunotherapy response | Cell Discovery | 2021 | 109 |
| 39 | Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation | Cell Discovery | 2017 | 106 |
| 40 | Robust induction of B cell and T cell responses by a third dose of inactivated SARS-CoV-2 vaccine | Cell Discovery | 2022 | 100 |
| 41 | TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling | Cell Discovery | 2018 | 97 |
| 42 | SG formation relies on eIF4GI-G3BP interaction which is targeted by picornavirus stress antagonists | Cell Discovery | 2019 | 96 |
| 43 | Absorbed plant MIR2911 in honeysuckle decoction inhibits SARS-CoV-2 replication and accelerates the negative conversion of infected patients | Cell Discovery | 2020 | 96 |
| 44 | Long read reference genome-free reconstruction of a full-length transcriptome from Astragalus membranaceus reveals transcript variants involved in bioactive compound biosynthesis | Cell Discovery | 2017 | 95 |
| 45 | miRNA-200c-3p is crucial in acute respiratory distress syndrome | Cell Discovery | 2017 | 95 |
| 46 | Plasma membrane integrity in health and disease: significance and therapeutic potential | Cell Discovery | 2021 | 92 |
| 47 | MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase-deficient and crotonyltransferase-competent CBP/p300 | Cell Discovery | 2017 | 91 |
| 48 | Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages | Cell Discovery | 2021 | 91 |
| 49 | Emerging functions of branched ubiquitin chains | Cell Discovery | 2021 | 91 |
| 50 | TRIM29 negatively controls antiviral immune response through targeting STING for degradation | Cell Discovery | 2018 | 90 |
