| 1 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 7,509 |
| 2 | Biological properties of extracellular vesicles and their physiological functions | Journal of Extracellular Vesicles | 2015 | 4,125 |
| 3 | Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles | Journal of Extracellular Vesicles | 2014 | 2,071 |
| 4 | Routes and mechanisms of extracellular vesicle uptake | Journal of Extracellular Vesicles | 2014 | 2,003 |
| 5 | Standardization of sample collection, isolation and analysis methods in extracellular vesicle research | Journal of Extracellular Vesicles | 2013 | 1,790 |
| 6 | Optimized exosome isolation protocol for cell culture supernatant and human plasma | Journal of Extracellular Vesicles | 2015 | 1,239 |
| 7 | Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting | Journal of Extracellular Vesicles | 2015 | 1,164 |
| 8 | Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper | Journal of Extracellular Vesicles | 2015 | 1,077 |
| 9 | Single‐step isolation of extracellular vesicles by size‐exclusion chromatography | Journal of Extracellular Vesicles | 2014 | 832 |
| 10 | Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes | Journal of Extracellular Vesicles | 2013 | 768 |
| 11 | Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches | Journal of Extracellular Vesicles | 2024 | 765 |
| 12 | Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey | Journal of Extracellular Vesicles | 2016 | 751 |
| 13 | The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling | Journal of Extracellular Vesicles | 2014 | 701 |
| 14 | As we wait: coping with an imperfect nomenclature for extracellular vesicles | Journal of Extracellular Vesicles | 2013 | 676 |
| 15 | Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell‐free blood | Journal of Extracellular Vesicles | 2014 | 650 |
| 16 | Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper | Journal of Extracellular Vesicles | 2017 | 564 |
| 17 | How pure are your vesicles? | Journal of Extracellular Vesicles | 2013 | 548 |
| 18 | High‐resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources | Journal of Extracellular Vesicles | 2016 | 531 |
| 19 | Cellular stress conditions are reflected in the protein and RNA content of endothelial cell‐derived exosomes | Journal of Extracellular Vesicles | 2012 | 506 |
| 20 | Defining mesenchymal stromal cell (MSC)‐derived small extracellular vesicles for therapeutic applications | Journal of Extracellular Vesicles | 2019 | 440 |
| 21 | Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation | Journal of Extracellular Vesicles | 2012 | 432 |
| 22 | Macrophage‐dependent clearance of systemically administered B16BL6‐derived exosomes from the blood circulation in mice | Journal of Extracellular Vesicles | 2015 | 431 |
| 23 | Extracellular vesicle sizing and enumeration by nanoparticle tracking analysis | Journal of Extracellular Vesicles | 2013 | 422 |
| 24 | Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells | Journal of Extracellular Vesicles | 2017 | 416 |
| 25 | Inhibiting extracellular vesicles formation and release: a review of EV inhibitors | Journal of Extracellular Vesicles | 2020 | 416 |
| 26 | EVpedia: an integrated database of high‐throughput data for systemic analyses of extracellular vesicles | Journal of Extracellular Vesicles | 2013 | 402 |
| 27 | High‐speed centrifugation induces aggregation of extracellular vesicles | Journal of Extracellular Vesicles | 2015 | 398 |
| 28 | Extracellular vesicles or exosomes? On primacy, precision, and popularity influencing a choice of nomenclature | Journal of Extracellular Vesicles | 2019 | 391 |
| 29 | Quality and efficiency assessment of six extracellular vesicle isolation methods by nano‐flow cytometry | Journal of Extracellular Vesicles | 2020 | 387 |
| 30 | Extracellular vesicle measurements with nanoparticle tracking analysis – An accuracy and repeatability comparison between NanoSight NS300 and ZetaView | Journal of Extracellular Vesicles | 2019 | 362 |
| 31 | The influence of rotor type and centrifugation time on the yield and purity of extracellular vesicles | Journal of Extracellular Vesicles | 2014 | 348 |
| 32 | Ginger‐derived nanoparticles protect against alcohol‐induced liver damage | Journal of Extracellular Vesicles | 2015 | 347 |
| 33 | Display of GPI‐anchored anti‐EGFR nanobodies on extracellular vesicles promotes tumour cell targeting | Journal of Extracellular Vesicles | 2016 | 322 |
| 34 | Importance of exosome depletion protocols to eliminate functional and RNA‐containing extracellular vesicles from fetal bovine serum | Journal of Extracellular Vesicles | 2014 | 318 |
| 35 | Exosomal miRNAs as cancer biomarkers and therapeutic targets | Journal of Extracellular Vesicles | 2016 | 315 |
| 36 | Comparative marker analysis of extracellular vesicles in different human cancer types | Journal of Extracellular Vesicles | 2013 | 314 |
| 37 | ExoCarta as a resource for exosomal research | Journal of Extracellular Vesicles | 2012 | 305 |
| 38 | Large extracellular vesicles carry most of the tumour DNA circulating in prostate cancer patient plasma | Journal of Extracellular Vesicles | 2018 | 284 |
| 39 | MIFlowCyt‐EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments | Journal of Extracellular Vesicles | 2020 | 283 |
| 40 | Simplified protocol for flow cytometry analysis of fluorescently labeled exosomes and microvesicles using dedicated flow cytometer | Journal of Extracellular Vesicles | 2015 | 282 |
| 41 | Co‐isolation of extracellular vesicles and high‐density lipoproteins using density gradient ultracentrifugation | Journal of Extracellular Vesicles | 2014 | 274 |
| 42 | A novel community driven software for functional enrichment analysis of extracellular vesicles data | Journal of Extracellular Vesicles | 2017 | 274 |
| 43 | A brief history of nearly EV‐erything – The rise and rise of extracellular vesicles | Journal of Extracellular Vesicles | 2021 | 273 |
| 44 | Comparative analysis of discrete exosome fractions obtained by differential centrifugation | Journal of Extracellular Vesicles | 2014 | 263 |
| 45 | Comparison of small extracellular vesicles isolated from plasma by ultracentrifugation or size‐exclusion chromatography: yield, purity and functional potential | Journal of Extracellular Vesicles | 2019 | 259 |
| 46 | Single exosome study reveals subpopulations distributed among cell lines with variability related to membrane content | Journal of Extracellular Vesicles | 2015 | 253 |
| 47 | Isolation and characterization of platelet‐derived extracellular vesicles | Journal of Extracellular Vesicles | 2014 | 248 |
| 48 | Exosomal proteins as potential diagnostic markers in advanced non‐small cell lung carcinoma | Journal of Extracellular Vesicles | 2015 | 247 |
| 49 | Physical exercise induces rapid release of small extracellular vesicles into the circulation | Journal of Extracellular Vesicles | 2015 | 247 |
| 50 | Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane | Journal of Extracellular Vesicles | 2017 | 247 |