# | Title | Journal | Year | Citations |
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1 | An epigenetic biomarker of aging for lifespan and healthspan | Aging | 2018 | 1,552 |
2 | DNA methylation GrimAge strongly predicts lifespan and healthspan | Aging | 2019 | 1,128 |
3 | Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies | Aging | 2016 | 1,014 |
4 | Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis | Aging | 2020 | 965 |
5 | DNA methylation-based measures of biological age: meta-analysis predicting time to death | Aging | 2016 | 786 |
6 | Why does COVID-19 disproportionately affect older people? | Aging | 2020 | 708 |
7 | Epigenetic clock analysis of diet, exercise, education, and lifestyle factors | Aging | 2017 | 521 |
8 | Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging | Aging | 2011 | 520 |
9 | New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463 | Aging | 2017 | 469 |
10 | Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy | Aging | 2010 | 462 |
11 | Role of Apoptosis in disease | Aging | 2012 | 448 |
12 | Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle | Aging | 2009 | 428 |
13 | MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8 | Aging | 2009 | 420 |
14 | Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies | Aging | 2018 | 406 |
15 | Inflammaging: disturbed interplay between autophagy and inflammasomes | Aging | 2012 | 379 |
16 | Polyamines in aging and disease | Aging | 2011 | 376 |
17 | Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning | Aging | 2015 | 368 |
18 | Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patients | Aging | 2015 | 344 |
19 | ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy | Aging | 2020 | 331 |
20 | Markers of cellular senescence. Telomere shortening as a marker of cellular senescence | Aging | 2016 | 312 |
21 | Mining TCGA database for genes of prognostic value in glioblastoma microenvironment | Aging | 2018 | 311 |
22 | Global, regional, and national prevalence and disability-adjusted life-years for infertility in 195 countries and territories, 1990–2017: results from a global burden of disease study, 2017 | Aging | 2019 | 310 |
23 | Fasting and cancer treatment in humans: A case series report | Aging | 2009 | 305 |
24 | Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis | Aging | 2020 | 298 |
25 | The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway | Aging | 2010 | 281 |
26 | Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues | Aging | 2013 | 280 |
27 | Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring | Aging | 2015 | 276 |
28 | SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair | Aging | 2009 | 270 |
29 | The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men: a novel demonstration | Aging | 2008 | 270 |
30 | Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy | Aging | 2009 | 270 |
31 | Deep biomarkers of human aging: Application of deep neural networks to biomarker development | Aging | 2016 | 266 |
32 | Functional metagenomic profiling of intestinal microbiome in extreme ageing | Aging | 2013 | 263 |
33 | Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells | Aging | 2016 | 261 |
34 | CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630 | Aging | 2017 | 259 |
35 | Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues | Aging | 2012 | 258 |
36 | Age-related changes in microRNA levels in serum | Aging | 2013 | 257 |
37 | DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative | Aging | 2015 | 254 |
38 | Epigenetic-aging-signature to determine age in different tissues | Aging | 2011 | 248 |
39 | Sarcopenia, obesity, and natural killer cell immune senescence in aging: Altered cytokine levels as a common mechanism | Aging | 2012 | 247 |
40 | If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice | Aging | 2011 | 244 |
41 | p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli | Aging | 2017 | 244 |
42 | Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1 | Aging | 2020 | 244 |
43 | A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction | Aging | 2010 | 231 |
44 | IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine ‘Bystander senescence’ | Aging | 2012 | 231 |
45 | Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging | Aging | 2012 | 224 |
46 | miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues | Aging | 2010 | 217 |
47 | Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin | Aging | 2012 | 215 |
48 | Complete cardiac regeneration in a mouse model of myocardial infarction | Aging | 2012 | 214 |
49 | NKG2D ligands mediate immunosurveillance of senescent cells | Aging | 2016 | 211 |
50 | The sirtuins, oxidative stress and aging: an emerging link | Aging | 2013 | 209 |