| 1 | OncoKB: A Precision Oncology Knowledge Base | JCO Precision Oncology | 2017 | 1,457 |
| 2 | Next-Generation Sequencing Directs Therapy and Delineates a Clonal Relationship in Mast Cell Sarcoma and Acute Myeloid Leukemia | JCO Precision Oncology | 2019 | 349 |
| 3 | Intermittent Treatment With MEK Inhibitors in Patients With Oncogenic RAF-Driven Tumors: A Potential Strategy to Manage Toxicity and Maintain Efficacy | JCO Precision Oncology | 2018 | 274 |
| 4 | Acral Lentiginous Melanoma Harboring a ROS1 Gene Fusion With Clinical Response to Entrectinib | JCO Precision Oncology | 2017 | 263 |
| 5 | Dramatic Response to Crizotinib in a Patient With Lung Cancer Positive for an HLA-DRB1-MET Gene Fusion | JCO Precision Oncology | 2017 | 92 |
| 6 | Immunophenotype and Response to Immunotherapy of RET-Rearranged Lung Cancers | JCO Precision Oncology | 2019 | 90 |
| 7 | Rationale and Design of the Targeted Agent and Profiling Utilization Registry Study | JCO Precision Oncology | 2018 | 88 |
| 8 | Targeting HER2 Alterations in Non–Small-Cell Lung Cancer: A Comprehensive Review | JCO Precision Oncology | 2020 | 86 |
| 9 | Acquired ALK and RET Gene Fusions as Mechanisms of Resistance to Osimertinib in EGFR-Mutant Lung Cancers | JCO Precision Oncology | 2018 | 73 |
| 10 | METExon 14 Skipping Mutations in Non–Small-Cell Lung Cancer: An Overview of Biology, Clinical Outcomes, and Testing Considerations | JCO Precision Oncology | 2021 | 68 |
| 11 | Homologous Recombination Deficiency in Breast Cancer: A Clinical Review | JCO Precision Oncology | 2017 | 62 |
| 12 | Clinical Outcomes of Molecular Tumor Boards: A Systematic Review | JCO Precision Oncology | 2021 | 61 |
| 13 | Systematic Review of Molecular Biomarkers Predictive of Resistance to CDK4/6 Inhibition in Metastatic Breast Cancer | JCO Precision Oncology | 2022 | 60 |
| 14 | Impact of Clinical Practice Gaps on the Implementation of Personalized Medicine in Advanced Non–Small-Cell Lung Cancer | JCO Precision Oncology | 2022 | 56 |
| 15 | Precision Oncology and the Universal Health Coverage System in Japan | JCO Precision Oncology | 2019 | 53 |
| 16 | Biomarker-Driven Oncology Clinical Trials: Key Design Elements, Types, Features, and Practical Considerations | JCO Precision Oncology | 2019 | 53 |
| 17 | Genomic Characterization of Prostatic Ductal Adenocarcinoma Identifies a High Prevalence of DNA Repair Gene Mutations | JCO Precision Oncology | 2019 | 52 |
| 18 | Analytical Concordance of PD-L1 Assays Utilizing Antibodies From FDA-Approved Diagnostics in Advanced Cancers: A Systematic Literature Review | JCO Precision Oncology | 2021 | 48 |
| 19 | Impact of Circulating Tumor DNA–Based Detection of Molecular Residual Disease on the Conduct and Design of Clinical Trials for Solid Tumors | JCO Precision Oncology | 2022 | 47 |
| 20 | PIK3CAMutations Drive Therapeutic Resistance in Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer | JCO Precision Oncology | 2022 | 46 |
| 21 | Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care | JCO Precision Oncology | 2022 | 42 |
| 22 | Mismatch Repair Deficiency in High-Grade Meningioma: A Rare but Recurrent Event Associated With Dramatic Immune Activation and Clinical Response to PD-1 Blockade | JCO Precision Oncology | 2018 | 41 |
| 23 | Acquired
MET
Exon 14 Alteration Drives Secondary Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in
EGFR
-Mutated Lung Cancer | JCO Precision Oncology | 2019 | 41 |
| 24 | Drug-Related Pneumonitis in the Era of Precision Cancer Therapy | JCO Precision Oncology | 2017 | 40 |
| 25 | Cascade Genetic Testing for Hereditary Cancer Risk: An Underutilized Tool for Cancer Prevention | JCO Precision Oncology | 2021 | 39 |
| 26 | Comprehensive Review on the Clinical Impact of Next-Generation Sequencing Tests for the Management of Advanced Cancer | JCO Precision Oncology | 2023 | 39 |
| 27 | Model-Assisted Designs for Early-Phase Clinical Trials: Simplicity Meets Superiority | JCO Precision Oncology | 2019 | 37 |
| 28 | Recommendations for the Equitable and Widespread Implementation of Liquid Biopsy for Cancer Care | JCO Precision Oncology | 2024 | 36 |
| 29 | First Report of Clinical Response to Venetoclax in Early T-Cell Precursor Acute Lymphoblastic Leukemia | JCO Precision Oncology | 2018 | 34 |
| 30 | Entrectinib in TRK and ROS1 Fusion-Positive Metastatic Pancreatic Cancer | JCO Precision Oncology | 2018 | 33 |
| 31 | Clinical Utility of CDK4/6 Inhibitors in Sarcoma: Successes and Future Challenges | JCO Precision Oncology | 2022 | 33 |
| 32 | Acquired Resistance to Poly (ADP-ribose) Polymerase Inhibitor Olaparib in BRCA2-Associated Prostate Cancer Resulting From Biallelic BRCA2 Reversion Mutations Restores Both Germline and Somatic Loss-of-Function Mutations | JCO Precision Oncology | 2018 | 32 |
| 33 | Response of Brain Metastases From PIK3CA-Mutant Breast Cancer to Alpelisib | JCO Precision Oncology | 2020 | 32 |
| 34 | Response and Mechanisms of Resistance to Larotrectinib and Selitrectinib in Metastatic Undifferentiated Sarcoma Harboring Oncogenic Fusion of NTRK1 | JCO Precision Oncology | 2020 | 32 |
| 35 | Successful Targeted Therapy of Refractory Pediatric ETV6-NTRK3 Fusion-Positive Secretory Breast Carcinoma | JCO Precision Oncology | 2017 | 30 |
| 36 | ALK Fusions in Renal Cell Carcinoma: Response to Entrectinib | JCO Precision Oncology | 2018 | 29 |
| 37 | Response to Selective RET Inhibition With LOXO-292 in a Patient With
RET
Fusion-Positive Lung Cancer With Leptomeningeal Metastases | JCO Precision Oncology | 2019 | 29 |
| 38 | Developing and Validating Risk Assessment Models of Clinical Outcomes in Modern Oncology | JCO Precision Oncology | 2019 | 29 |
| 39 | Activity of the Highly Specific RET Inhibitor Selpercatinib (LOXO-292) in Pediatric Patients With Tumors Harboring RET Gene Alterations | JCO Precision Oncology | 2020 | 29 |
| 40 | Complete and Prolonged Response to Immune Checkpoint Blockade in POLE-Mutated Colorectal Cancer | JCO Precision Oncology | 2019 | 28 |
| 41 | Integrating Somatic and Germline Next-Generation Sequencing Into Routine Clinical Oncology Practice | JCO Precision Oncology | 2021 | 28 |
| 42 | Phase Ib SEASTAR Study: Combining Rucaparib and Sacituzumab Govitecan in Patients With Cancer With or Without Mutations in Homologous Recombination Repair Genes | JCO Precision Oncology | 2022 | 28 |
| 43 | Economic Evaluations of Next-Generation Precision Oncology: A Critical Review | JCO Precision Oncology | 2018 | 27 |
| 44 | Venetoclax and Bortezomib in Relapsed/Refractory Early T-Cell Precursor Acute Lymphoblastic Leukemia | JCO Precision Oncology | 2019 | 27 |
| 45 | Next-Generation Sequencing and the Clinical Oncology Workflow: Data Challenges, Proposed Solutions, and a Call to Action | JCO Precision Oncology | 2019 | 26 |
| 46 | Genomic Alterations in Head and Neck Squamous Cell Carcinoma: Level of Evidence According to ESMO Scale for Clinical Actionability of Molecular Targets (ESCAT) | JCO Precision Oncology | 2021 | 26 |
| 47 | STRN-ALK Rearranged Malignant Peritoneal Mesothelioma With Dramatic Response Following Ceritinib Treatment | JCO Precision Oncology | 2019 | 25 |
| 48 | Implications of Clonal Hematopoiesis for Precision Oncology | JCO Precision Oncology | 2020 | 24 |
| 49 | Inherited Susceptibility to Hematopoietic Malignancies in the Era of Precision Oncology | JCO Precision Oncology | 2021 | 24 |
| 50 | A Systematic Review and Meta-Analysis on the Predictive Value of Cell-Free DNA–Based Androgen Receptor Copy Number Gain in Patients With Castration-Resistant Prostate Cancer | JCO Precision Oncology | 2020 | 23 |