Combinatorial Chemistry and High Throughput Screening

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#	Title	Journal	Year	Citations
1	Privileged Structures: Applications in Drug Discovery	Combinatorial Chemistry and High Throughput Screening	2004	494
2	Evaluation of the Antioxidant Potential of Natural Products	Combinatorial Chemistry and High Throughput Screening	1998	406
3	Computational Methods in Developing Quantitative Structure-Activity Relationships (QSAR): A Review	Combinatorial Chemistry and High Throughput Screening	2006	324
4	Recent Advances on Potentiometric Membrane Sensors for Pharmaceutical Analysis	Combinatorial Chemistry and High Throughput Screening	2011	306
5	Metalloproteinase Inhibitors for the Disintegrin-Like Metalloproteinases ADAM10 and ADAM17 that Differentially Block Constitutive and Phorbol Ester-Inducible Shedding of Cell Surface Molecules	Combinatorial Chemistry and High Throughput Screening	2005	293
6	Label-Free Detection of Biomolecular Interactions Using BioLayer Interferometry for Kinetic Characterization	Combinatorial Chemistry and High Throughput Screening	2009	285
7	On Various Metrics Used for Validation of Predictive QSAR Models with Applications in Virtual Screening and Focused Library Design	Combinatorial Chemistry and High Throughput Screening	2011	246
8	Evaluation of the antioxidant potential of natural products	Combinatorial Chemistry and High Throughput Screening	1998	234
9	Diversity Among Microbial Cyclic Lipopeptides: Iturins and Surfactins. Activity-Structure Relationships to Design New Bioactive Agents	Combinatorial Chemistry and High Throughput Screening	2003	229
10	Antioxidants and Inflammatory Disease: Synthetic and Natural Antioxidants with Anti-Inflammatory Activity	Combinatorial Chemistry and High Throughput Screening	2006	196
11	Molecular Mechanisms of Membrane Perturbation by Antimicrobial Peptides and the Use of Biophysical Studies in the Design of Novel Peptide Antibiotics	Combinatorial Chemistry and High Throughput Screening	2005	194
12	Building a Tiered Approach to In Vitro Predictive Toxicity Screening: A Focus on Assays with In Vivo Relevance	Combinatorial Chemistry and High Throughput Screening	2010	181
13	BindingDB: A Web-Accessible Molecular Recognition Database	Combinatorial Chemistry and High Throughput Screening	2001	172
14	Gene Assessment and Sample Classification for Gene Expression Data Using a Genetic Algorithm / k-nearest Neighbor Method	Combinatorial Chemistry and High Throughput Screening	2001	169
15	Machine Learning in Virtual Screening	Combinatorial Chemistry and High Throughput Screening	2009	169
16	Molecular Descriptors in Chemoinformatics, Computational Combinatorial Chemistry, and Virtual Screening	Combinatorial Chemistry and High Throughput Screening	2000	168
17	Peptidomics The Comprehensive Analysis of Peptides in Complex Biological Mixtures	Combinatorial Chemistry and High Throughput Screening	2012	166
18	A Decade of Yeast Surface Display Technology: Where Are We Now?	Combinatorial Chemistry and High Throughput Screening	2008	161
19	The Linear Interaction Energy Method for Predicting Ligand Binding Free Energies	Combinatorial Chemistry and High Throughput Screening	2001	156
20	Isocyanide Based Multi Component Reactions in Combinatorial Chemistry	Combinatorial Chemistry and High Throughput Screening	1998	156
21	Grouping of Coefficients for the Calculation of Inter-Molecular Similarity and Dissimilarity using 2D Fragment Bit-Strings	Combinatorial Chemistry and High Throughput Screening	2002	155
22	Gel-Based Versus Gel-Free Proteomics: A Review	Combinatorial Chemistry and High Throughput Screening	2005	149
23	The Multicomponent Reactions and their Libraries for Natural and Preparative Chemistry	Combinatorial Chemistry and High Throughput Screening	1970	134
24	Microwave Reactions Under Continuous Flow Conditions	Combinatorial Chemistry and High Throughput Screening	2007	130
25	Plasma Protein Binding in Drug Discovery and Development	Combinatorial Chemistry and High Throughput Screening	2010	124
26	Integrating Virtual Screening and Combinatorial Chemistry for Accelerated Drug Discovery	Combinatorial Chemistry and High Throughput Screening	2011	122
27	Application of NMR Metabolomics to Search for Human Disease Biomarkers	Combinatorial Chemistry and High Throughput Screening	2012	116
28	Structure-Based Virtual Ligand Screening: Recent Success Stories	Combinatorial Chemistry and High Throughput Screening	2009	114
29	Virtual Screening Methods that Complement HTS	Combinatorial Chemistry and High Throughput Screening	2004	113
30	Defensins and Other Antimicrobial Peptides: A Historical Perspective and an Update	Combinatorial Chemistry and High Throughput Screening	2005	108
31	Anticancer Properties of Traditional Chinese Medicine	Combinatorial Chemistry and High Throughput Screening	2017	106
32	Phenotypic Screening of Small Molecule Libraries by High Throughput Cell Imaging	Combinatorial Chemistry and High Throughput Screening	2003	106
33	Microarray Technology as a Universal Tool for High-Throughput Analysis of Biological Systems	Combinatorial Chemistry and High Throughput Screening	2006	105
34	Antioxidant Activity of Two Wild Edible Mushrooms (Morchella vulgaris and Morchella esculanta) from North Turkey	Combinatorial Chemistry and High Throughput Screening	2006	104
35	A Ligand-Based Approach to Mining the Chemogenomic Space of Drugs	Combinatorial Chemistry and High Throughput Screening	2008	104
36	Recent Advances in Biocatalysis by Directed Enzyme Evolution	Combinatorial Chemistry and High Throughput Screening	2006	103
37	Recent Advances on Aqueous Solubility Prediction	Combinatorial Chemistry and High Throughput Screening	2011	102
38	Development and Application of Fluorescence Polarization Assays in Drug Discovery	Combinatorial Chemistry and High Throughput Screening	2003	101
39	In Vitro High Throughput Screening of Compounds for Favorable Metabolic Properties in Drug Discovery.	Combinatorial Chemistry and High Throughput Screening	2001	100
40	The Design and Application of Target-Focused Compound Libraries	Combinatorial Chemistry and High Throughput Screening	2011	98
41	Chemogenomic Data Analysis: Prediction of Small-Molecule Targets and the Advent of Biological Fingerprints	Combinatorial Chemistry and High Throughput Screening	2007	97
42	Fluorescence Polarization: An Analytical Tool for Immunoassay and_ Drug Discovery	Combinatorial Chemistry and High Throughput Screening	1999	95
43	The Diversity Challenge in Directed Protein Evolution	Combinatorial Chemistry and High Throughput Screening	2006	92
44	Evolution of the Human Ion Channel Set	Combinatorial Chemistry and High Throughput Screening	2009	90
45	Targeting the Hemozoin Synthesis Pathway for New Antimalarial Drug Discovery: Technologies for In Vitro β-Hematin Formation Assay	Combinatorial Chemistry and High Throughput Screening	2005	88
46	Accelerating Research into Bio-Based FDCA-Polyesters by Using Small Scale Parallel Film Reactors	Combinatorial Chemistry and High Throughput Screening	2012	84
47	Fluorescence Polarization: Past, Present and Future	Combinatorial Chemistry and High Throughput Screening	2003	84
48	High Throughput Screening of Physicochemical Properties and In Vitro ADME Profiling in Drug Discovery	Combinatorial Chemistry and High Throughput Screening	2009	83
49	Digital Holographic Microscopy: A Quantitative Label-Free Microscopy Technique for Phenotypic Screening	Combinatorial Chemistry and High Throughput Screening	2014	83
50	DNA and RNA Aptamers: From Tools for Basic Research Towards Therapeutic Applications	Combinatorial Chemistry and High Throughput Screening	2006	82

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