| # | Title | Journal | Year | Citations |
|---|
| 1 | The hierarchy quorum sensing network in Pseudomonas aeruginosa | Protein and Cell | 2015 | 930 |
| 2 | CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes | Protein and Cell | 2015 | 929 |
| 3 | Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy | Protein and Cell | 2021 | 837 |
| 4 | NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer | Protein and Cell | 2013 | 516 |
| 5 | Structure and function of WD40 domain proteins | Protein and Cell | 2011 | 494 |
| 6 | Antibody-drug conjugates: recent advances in conjugation and linker chemistries | Protein and Cell | 2018 | 494 |
| 7 | Cholesterol metabolism and homeostasis in the brain | Protein and Cell | 2015 | 458 |
| 8 | Oral microbiomes: more and more importance in oral cavity and whole body | Protein and Cell | 2018 | 449 |
| 9 | Alpha-helical cationic antimicrobial peptides: relationships of structure and function | Protein and Cell | 2010 | 407 |
| 10 | Structural and functional roles of ether lipids | Protein and Cell | 2018 | 387 |
| 11 | A practical guide to amplicon and metagenomic analysis of microbiome data | Protein and Cell | 2021 | 376 |
| 12 | Regulation of the pentose phosphate pathway in cancer | Protein and Cell | 2014 | 363 |
| 13 | Human gut microbiome: the second genome of human body | Protein and Cell | 2010 | 347 |
| 14 | The emerging role and targetability of the TCA cycle in cancer metabolism | Protein and Cell | 2018 | 345 |
| 15 | Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids | Protein and Cell | 2020 | 313 |
| 16 | Mitochondria-mediated apoptosis in mammals | Protein and Cell | 2014 | 311 |
| 17 | The crosstalk between autophagy and apoptosis: where does this lead? | Protein and Cell | 2012 | 295 |
| 18 | Gut microbiota derived metabolites in cardiovascular health and disease | Protein and Cell | 2018 | 274 |
| 19 | Functional metabolomics: from biomarker discovery to metabolome reprogramming | Protein and Cell | 2015 | 269 |
| 20 | TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization | Protein and Cell | 2017 | 263 |
| 21 | Biogenesis and regulation of the let-7 miRNAs and their functional implications | Protein and Cell | 2016 | 253 |
| 22 | The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists | Protein and Cell | 2013 | 247 |
| 23 | The impact of acetylation and deacetylation on the p53 pathway | Protein and Cell | 2011 | 242 |
| 24 | IgG Fc engineering to modulate antibody effector functions | Protein and Cell | 2018 | 242 |
| 25 | SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex | Protein and Cell | 2014 | 234 |
| 26 | Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control | Protein and Cell | 2014 | 230 |
| 27 | Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins | Protein and Cell | 2018 | 224 |
| 28 | Horizontal transfer of microRNAs: molecular mechanisms and clinical applications | Protein and Cell | 2012 | 223 |
| 29 | Inflammasomes in cancer: a double-edged sword | Protein and Cell | 2014 | 221 |
| 30 | Understand spiciness: mechanism of TRPV1 channel activation by capsaicin | Protein and Cell | 2017 | 219 |
| 31 | Current progress in innovative engineered antibodies | Protein and Cell | 2018 | 217 |
| 32 | Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis | Protein and Cell | 2010 | 208 |
| 33 | Role of Notch signaling in regulating innate immunity and inflammation in health and disease | Protein and Cell | 2016 | 206 |
| 34 | Cancer stem cells in glioblastoma—molecular signaling and therapeutic targeting | Protein and Cell | 2010 | 204 |
| 35 | The association of diet, gut microbiota and colorectal cancer: what we eat may imply what we get | Protein and Cell | 2018 | 204 |
| 36 | Microbiota transplantation: concept, methodology and strategy for its modernization | Protein and Cell | 2018 | 201 |
| 37 | MAPK signaling in inflammation-associated cancer development | Protein and Cell | 2010 | 200 |
| 38 | SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion | Protein and Cell | 2011 | 200 |
| 39 | Human gut microbiota: the links with dementia development | Protein and Cell | 2017 | 199 |
| 40 | Phase I study of chimeric antigen receptor modified T cells in treating HER2-positive advanced biliary tract cancers and pancreatic cancers | Protein and Cell | 2018 | 196 |
| 41 | c-Jun, at the crossroad of the signaling network | Protein and Cell | 2011 | 192 |
| 42 | MiR-122 in hepatic function and liver diseases | Protein and Cell | 2012 | 188 |
| 43 | Effect of pH, temperature and freezing-thawing on quantity changes and cellular uptake of exosomes | Protein and Cell | 2019 | 188 |
| 44 | Structural insight into substrate specificity of human intestinal maltase-glucoamylase | Protein and Cell | 2011 | 185 |
| 45 | H9N2 influenza virus in China: a cause of concern | Protein and Cell | 2015 | 182 |
| 46 | The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells | Protein and Cell | 2017 | 182 |
| 47 | Correction of β-thalassemia mutant by base editor in human embryos | Protein and Cell | 2017 | 182 |
| 48 | Carboxylesterases in lipid metabolism: from mouse to human | Protein and Cell | 2018 | 182 |
| 49 | The role of BRCA1 in DNA damage response | Protein and Cell | 2010 | 179 |
| 50 | Human catalase: looking for complete identity | Protein and Cell | 2010 | 179 |
