ATLA Alternatives To Laboratory Animals

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#	Title	Journal	Year	Citations
1	Current Status of Methods for Defining the Applicability Domain of (Quantitative) Structure-Activity Relationships	ATLA Alternatives To Laboratory Animals	2005	676
2	QSAR Applicability Domain Estimation by Projection of the Training Set in Descriptor Space: A Review	ATLA Alternatives To Laboratory Animals	2005	552
3	A Multicompartmental Dynamic Computer-controlled Model Simulating the Stomach and Small Intestine	ATLA Alternatives To Laboratory Animals	1995	550
4	The ECVAM International Validation Study on In Vitro Embryotoxicity Tests: Results of the Definitive Phase and Evaluation of Prediction Models	ATLA Alternatives To Laboratory Animals	2002	365
5	Validation of the Embryonic Stem Cell Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests	ATLA Alternatives To Laboratory Animals	2004	320
6	Guidance on Good Cell Culture Practice	ATLA Alternatives To Laboratory Animals	2005	302
7	Chicken Egg Yolk Antibodies (IgY-technology): A Review of Progress in Production and Use in Research and Human and Veterinary Medicine	ATLA Alternatives To Laboratory Animals	2005	284
8	A Modular Approach to the ECVAM Principles on Test Validity	ATLA Alternatives To Laboratory Animals	2004	278
9	A Gold Standard Publication Checklist to Improve the Quality of Animal Studies, to Fully Integrate the Three Rs, and to Make Systematic Reviews More Feasible	ATLA Alternatives To Laboratory Animals	2010	265
10	Practical Aspects of the Validation of Toxicity Test Procedures	ATLA Alternatives To Laboratory Animals	1995	241
11	The Use of Fetal Bovine Serum: Ethical or Scientific Problem?	ATLA Alternatives To Laboratory Animals	2002	214
12	Report and Recommendations of the CAAT/ERGATT Workshop on the Validation of Toxicity Test Procedures	ATLA Alternatives To Laboratory Animals	1990	201
13	The Use of Reconstructed Human Epidermis for Skin Absorption Testing: Results of the Validation Study	ATLA Alternatives To Laboratory Animals	2008	199
14	In Vitro Models of the Intestinal Barrier	ATLA Alternatives To Laboratory Animals	2001	197
15	The use of Fish Cells in Ecotoxicology: The Report and Recommendations of ECVAM Workshop 47^,	ATLA Alternatives To Laboratory Animals	2003	195
16	The ECVAM International Validation Study on in Vitro Tests for Acute Skin Irritation: Report on the Validity of the EPISKIN and EpiDerm Assays and on the Skin Integrity Function Test	ATLA Alternatives To Laboratory Animals	2007	192
17	Estimates for Worldwide Laboratory Animal Use in 2005	ATLA Alternatives To Laboratory Animals	2008	187
18	Metabolism: A Bottleneck inIn VitroToxicological Test Development	ATLA Alternatives To Laboratory Animals	2006	163
19	‘Human-on-a-chip’ Developments: A Translational Cutting-edge Alternative to Systemic Safety Assessment and Efficiency Evaluation of Substances in Laboratory Animals and Man?	ATLA Alternatives To Laboratory Animals	2012	157
20	The Role of Prevalidation in the Development, Validation and Acceptance of Alternative Methods	ATLA Alternatives To Laboratory Animals	1995	154
21	Methods for Assessing Percutaneous Absorption	ATLA Alternatives To Laboratory Animals	1996	149
22	A Review of the Implementation of the Embryonic Stem Cell Test (EST)	ATLA Alternatives To Laboratory Animals	2009	145
23	Anaesthesia and Post-operative Analgesia following Experimental Surgery in Laboratory Rodents: Are we Making Progress?	ATLA Alternatives To Laboratory Animals	2005	135
24	Detection of Oxidised Purines and UV-induced Photoproducts in DNA of Single Cells, by Inclusion of Lesion-specific Enzymes in the Comet Assay	ATLA Alternatives To Laboratory Animals	1996	132
25	Chemical Reactivity Measurement and the Predictive Identification of Skin Sensitisers	ATLA Alternatives To Laboratory Animals	2008	131
26	Validation of the Postimplantation Rat Whole-embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests	ATLA Alternatives To Laboratory Animals	2004	127
27	An Analysis of the Use of Animal Models in Predicting Human Toxicology and Drug Safety	ATLA Alternatives To Laboratory Animals	2014	125
28	A Review of In Silico Tools as Alternatives to Animal Testing: Principles, Resources and Applications	ATLA Alternatives To Laboratory Animals	2020	120
29	Applications of the Neutral Red Cytotoxicity Assay toIn VitroToxicology	ATLA Alternatives To Laboratory Animals	1990	116
30	The Registry of Cytotoxicity: Toxicity Testing in Cell Cultures to Predict Acute Toxicity (LD50) and to Reduce Testing in Animals	ATLA Alternatives To Laboratory Animals	2003	116
31	Testing Acute Toxicity in the Embryo of Zebrafish, Brachydanio rerio, as an Alternative to the Acute Fish Test: Preliminary Results	ATLA Alternatives To Laboratory Animals	1994	115
32	Biomarkers as Predictive Tools in Toxicity Testing	ATLA Alternatives To Laboratory Animals	2000	113
33	An Estimate of the Number of Animals Used for Scientific Purposes Worldwide in 2015	ATLA Alternatives To Laboratory Animals	2019	113
34	Exposure of Bronchial Epithelial Cells to Whole Cigarette Smoke: Assessment of Cellular Responses	ATLA Alternatives To Laboratory Animals	2005	111
35	The Practical Application of Three Validated In Vitro Embryotoxicity Tests	ATLA Alternatives To Laboratory Animals	2006	111
36	Reconstructed Human Epidermis for Skin Absorption Testing: Results of the German Prevalidation Study	ATLA Alternatives To Laboratory Animals	2006	110
37	A Comparative Evaluation of In Vitro Skin Sensitisation Tests: The Human Cell-line Activation Test (h-CLAT) versus the Local Lymph Node Assay (LLNA)	ATLA Alternatives To Laboratory Animals	2010	108
38	The Three Rs: The Way Forward	ATLA Alternatives To Laboratory Animals	1995	106
39	Cytotoxicity Evaluation of the First Ten MEIC Chemicals: Acute Lethal Toxicity in Man Predicted by Cytotoxicity in Five Cellular Assays and by Oral LD50 Tests in Rodents	ATLA Alternatives To Laboratory Animals	1989	105
40	Selection of Test Chemicals for the ECVAM International Validation Study on In Vitro Embryotoxicity Tests	ATLA Alternatives To Laboratory Animals	2002	103
41	MEIC Evaluation of Acute Systemic Toxicity	ATLA Alternatives To Laboratory Animals	1998	102
42	An Inter-laboratory Study to Evaluate the Effects of Medium Composition on the Differentiation and Barrier Function of Caco-2 Cell Lines	ATLA Alternatives To Laboratory Animals	2005	102
43	MEIC Evaluation of Acute Systemic Toxicity	ATLA Alternatives To Laboratory Animals	1996	102
44	Cell Transformation Assays as Predictors of Human Carcinogenicity	ATLA Alternatives To Laboratory Animals	1999	97
45	The Development and Validation of Expert Systems for Predicting Toxicity	ATLA Alternatives To Laboratory Animals	1997	96
46	Dendritic Cells as a Tool for the Predictive Identification of Skin Sensitisation Hazard	ATLA Alternatives To Laboratory Animals	2005	94
47	Determination of the Starting dose for Acute Oral Toxicity (LD50) Testing in the up and down Procedure (UDP) from Cytotoxicity Data	ATLA Alternatives To Laboratory Animals	1999	93
48	Results of a Validation Study in Germany on Two in Vitro Alternatives to the Draize Eye Irritation Test, the HET-CAM Test and the 3T3 NRU Cytotoxicity Test	ATLA Alternatives To Laboratory Animals	1996	93
49	The ECVAM Prevalidation Study on the Use of EpiDerm for Skin Corrosivity Testing	ATLA Alternatives To Laboratory Animals	2000	92
50	The EU White Paper: Strategy for a Future Chemicals Policy (an Idea that Must Have Seemed Good at the Time!)	ATLA Alternatives To Laboratory Animals	2002	89

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