# | Title | Journal | Year | Citations |
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1 | Hypoxia in cancer: significance and impact on clinical outcome | Cancer and Metastasis Reviews | 2007 | 1,918 |
2 | The distribution of secondary growths in cancer of the breast. 1889 | Cancer and Metastasis Reviews | 1989 | 1,827 |
3 | Matrix metalloproteinases and tumor metastasis | Cancer and Metastasis Reviews | 2006 | 1,712 |
4 | EMT, the cytoskeleton, and cancer cell invasion | Cancer and Metastasis Reviews | 2009 | 1,521 |
5 | Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review | Cancer and Metastasis Reviews | 2013 | 948 |
6 | Apoptosis induced by anticancer drugs | Cancer and Metastasis Reviews | 1992 | 820 |
7 | Transport of molecules across tumor vasculature | Cancer and Metastasis Reviews | 1987 | 807 |
8 | Vascular permeability factor (VPF, VEGF) in tumor biology | Cancer and Metastasis Reviews | 1993 | 791 |
9 | Mechanics, malignancy, and metastasis: The force journey of a tumor cell | Cancer and Metastasis Reviews | 2009 | 791 |
10 | Role of tumor-associated macrophages in tumor progression and invasion | Cancer and Metastasis Reviews | 2006 | 789 |
11 | Src family kinases in tumor progression and metastasis | Cancer and Metastasis Reviews | 2003 | 743 |
12 | TNF-α in promotion and progression of cancer | Cancer and Metastasis Reviews | 2006 | 725 |
13 | E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer | Cancer and Metastasis Reviews | 2009 | 718 |
14 | Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals | Cancer and Metastasis Reviews | 2010 | 685 |
15 | EMT, cell plasticity and metastasis | Cancer and Metastasis Reviews | 2016 | 672 |
16 | The signaling mechanism of ROS in tumor progression | Cancer and Metastasis Reviews | 2007 | 642 |
17 | CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression | Cancer and Metastasis Reviews | 2010 | 633 |
18 | Hypoxia: A key regulator of angiogenesis in cancer | Cancer and Metastasis Reviews | 2007 | 631 |
19 | MicroRNA function in cancer: oncogene or a tumor suppressor? | Cancer and Metastasis Reviews | 2009 | 613 |
20 | Origins, structures, and functions of circulating DNA in oncology | Cancer and Metastasis Reviews | 2016 | 586 |
21 | Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: A unifying concept in stress response biology | Cancer and Metastasis Reviews | 2004 | 584 |
22 | Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview | Cancer and Metastasis Reviews | 1992 | 555 |
23 | Senescent cells as a source of inflammatory factors for tumor progression | Cancer and Metastasis Reviews | 2010 | 550 |
24 | Stromal cells in tumor microenvironment and breast cancer | Cancer and Metastasis Reviews | 2013 | 536 |
25 | Signal transduction by focal adhesion kinase in cancer | Cancer and Metastasis Reviews | 2009 | 529 |
26 | The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions | Cancer and Metastasis Reviews | 2006 | 495 |
27 | Hypoxia and drug resistance | Cancer and Metastasis Reviews | 1994 | 493 |
28 | Type IV collagenases in tumor invasion and metastasis | Cancer and Metastasis Reviews | 1990 | 485 |
29 | A biochemical hallmark of apoptosis: Internucleosomal degradation of the genome | Cancer and Metastasis Reviews | 1992 | 485 |
30 | Role of MAP kinase in tumor progression and invasion | Cancer and Metastasis Reviews | 2003 | 482 |
31 | Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites | Cancer and Metastasis Reviews | 1988 | 481 |
32 | Transforming growth factor-β in cancer and metastasis | Cancer and Metastasis Reviews | 2006 | 479 |
33 | Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion | Cancer and Metastasis Reviews | 2009 | 477 |
34 | Regulation of tumor pH and the role of carbonic anhydrase 9 | Cancer and Metastasis Reviews | 2007 | 470 |
35 | Tumour vascularization: sprouting angiogenesis and beyond | Cancer and Metastasis Reviews | 2007 | 464 |
36 | Vascular and interstitial barriers to delivery of therapeutic agents in tumors | Cancer and Metastasis Reviews | 1990 | 461 |
37 | Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression | Cancer and Metastasis Reviews | 2012 | 448 |
38 | c-Met: structure, functions and potential for therapeutic inhibition | Cancer and Metastasis Reviews | 2003 | 447 |
39 | The cytoskeleton and cancer | Cancer and Metastasis Reviews | 2009 | 444 |
40 | P53, cell cycle control and apoptosis: Implications for cancer | Cancer and Metastasis Reviews | 1995 | 433 |
41 | Role of matrix metalloproteinases (MMPs) in colorectal cancer | Cancer and Metastasis Reviews | 2004 | 429 |
42 | Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity | Cancer and Metastasis Reviews | 2010 | 427 |
43 | Dual-specificity MAP kinase phosphatases (MKPs) and cancer | Cancer and Metastasis Reviews | 2008 | 417 |
44 | Mucins and mucin binding proteins in colorectal cancer | Cancer and Metastasis Reviews | 2004 | 414 |
45 | Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis | Cancer and Metastasis Reviews | 1995 | 404 |
46 | Detection of circulating tumour DNA in the blood (plasma/serum) of cancer patients | Cancer and Metastasis Reviews | 1999 | 402 |
47 | Hypoxia-driven selection of the metastatic phenotype | Cancer and Metastasis Reviews | 2007 | 387 |
48 | Clinging to life: cell to matrix adhesion and cell survival | Cancer and Metastasis Reviews | 2005 | 384 |
49 | Progression and metastasis of lung cancer | Cancer and Metastasis Reviews | 2016 | 373 |
50 | Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis | Cancer and Metastasis Reviews | 2013 | 370 |