| 1 | Hypoxia in cancer: significance and impact on clinical outcome | Cancer and Metastasis Reviews | 2007 | 2,062 |
| 2 | Matrix metalloproteinases and tumor metastasis | Cancer and Metastasis Reviews | 2006 | 1,777 |
| 3 | EMT, the cytoskeleton, and cancer cell invasion | Cancer and Metastasis Reviews | 2009 | 1,629 |
| 4 | Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review | Cancer and Metastasis Reviews | 2013 | 1,042 |
| 5 | Mechanics, malignancy, and metastasis: The force journey of a tumor cell | Cancer and Metastasis Reviews | 2009 | 861 |
| 6 | Role of tumor-associated macrophages in tumor progression and invasion | Cancer and Metastasis Reviews | 2006 | 845 |
| 7 | TNF-α in promotion and progression of cancer | Cancer and Metastasis Reviews | 2006 | 844 |
| 8 | Apoptosis induced by anticancer drugs | Cancer and Metastasis Reviews | 1992 | 838 |
| 9 | Transport of molecules across tumor vasculature | Cancer and Metastasis Reviews | 1987 | 831 |
| 10 | Vascular permeability factor (VPF, VEGF) in tumor biology | Cancer and Metastasis Reviews | 1993 | 809 |
| 11 | EMT, cell plasticity and metastasis | Cancer and Metastasis Reviews | 2016 | 779 |
| 12 | (null) | Cancer and Metastasis Reviews | 2003 | 765 |
| 13 | E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer | Cancer and Metastasis Reviews | 2009 | 749 |
| 14 | Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals | Cancer and Metastasis Reviews | 2010 | 743 |
| 15 | Origins, structures, and functions of circulating DNA in oncology | Cancer and Metastasis Reviews | 2016 | 726 |
| 16 | CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression | Cancer and Metastasis Reviews | 2010 | 674 |
| 17 | Hypoxia: A key regulator of angiogenesis in cancer | Cancer and Metastasis Reviews | 2007 | 672 |
| 18 | The signaling mechanism of ROS in tumor progression | Cancer and Metastasis Reviews | 2006 | 670 |
| 19 | MicroRNA function in cancer: oncogene or a tumor suppressor? | Cancer and Metastasis Reviews | 2009 | 644 |
| 20 | Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: A unifying concept in stress response biology | Cancer and Metastasis Reviews | 2004 | 625 |
| 21 | Senescent cells as a source of inflammatory factors for tumor progression | Cancer and Metastasis Reviews | 2010 | 613 |
| 22 | Stromal cells in tumor microenvironment and breast cancer | Cancer and Metastasis Reviews | 2012 | 612 |
| 23 | Gastric cancer: a comprehensive review of current and future treatment strategies | Cancer and Metastasis Reviews | 2020 | 594 |
| 24 | Signal transduction by focal adhesion kinase in cancer | Cancer and Metastasis Reviews | 2009 | 569 |
| 25 | Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview | Cancer and Metastasis Reviews | 1992 | 561 |
| 26 | The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions | Cancer and Metastasis Reviews | 2006 | 550 |
| 27 | Hypoxia and drug resistance | Cancer and Metastasis Reviews | 1994 | 518 |
| 28 | Tumour vascularization: sprouting angiogenesis and beyond | Cancer and Metastasis Reviews | 2007 | 511 |
| 29 | Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion | Cancer and Metastasis Reviews | 2009 | 500 |
| 30 | Regulation of tumor pH and the role of carbonic anhydrase 9 | Cancer and Metastasis Reviews | 2007 | 496 |
| 31 | The cytoskeleton and cancer | Cancer and Metastasis Reviews | 2009 | 494 |
| 32 | Type IV collagenases in tumor invasion and metastasis | Cancer and Metastasis Reviews | 1990 | 492 |
| 33 | A biochemical hallmark of apoptosis: Internucleosomal degradation of the genome | Cancer and Metastasis Reviews | 1992 | 491 |
| 34 | (null) | Cancer and Metastasis Reviews | 2003 | 491 |
| 35 | Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites | Cancer and Metastasis Reviews | 1988 | 487 |
| 36 | Transforming growth factor-β in cancer and metastasis | Cancer and Metastasis Reviews | 2006 | 486 |
| 37 | Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression | Cancer and Metastasis Reviews | 2011 | 478 |
| 38 | Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis | Cancer and Metastasis Reviews | 2013 | 478 |
| 39 | Vascular and interstitial barriers to delivery of therapeutic agents in tumors | Cancer and Metastasis Reviews | 1990 | 474 |
| 40 | (null) | Cancer and Metastasis Reviews | 2003 | 468 |
| 41 | Progression and metastasis of lung cancer | Cancer and Metastasis Reviews | 2016 | 464 |
| 42 | Dual-specificity MAP kinase phosphatases (MKPs) and cancer | Cancer and Metastasis Reviews | 2008 | 461 |
| 43 | Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity | Cancer and Metastasis Reviews | 2010 | 459 |
| 44 | Role of matrix metalloproteinases (MMPs) in colorectal cancer | Cancer and Metastasis Reviews | 2004 | 450 |
| 45 | The role of fibroblast activation protein in health and malignancy | Cancer and Metastasis Reviews | 2020 | 447 |
| 46 | P53, cell cycle control and apoptosis: Implications for cancer | Cancer and Metastasis Reviews | 1995 | 444 |
| 47 | Mucins and mucin binding proteins in colorectal cancer | Cancer and Metastasis Reviews | 2004 | 437 |
| 48 | HER2 expression status in diverse cancers: review of results from 37,992 patients | Cancer and Metastasis Reviews | 2015 | 435 |
| 49 | Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis | Cancer and Metastasis Reviews | 1995 | 414 |
| 50 | (null) | Cancer and Metastasis Reviews | 1999 | 412 |