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Top Articles

#TitleJournalYearCitations
1Matrigel: Basement membrane matrix with biological activitySeminars in Cancer Biology20051,318
2Immune evasion in cancer: Mechanistic basis and therapeutic strategiesSeminars in Cancer Biology20151,122
3The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissuesSeminars in Cancer Biology19991,044
4Macrophage polarization in tumour progressionSeminars in Cancer Biology20081,026
5The c-Myc target gene networkSeminars in Cancer Biology2006989
6The role of angiogenesis in tumor growthSeminars in Cancer Biology1992891
7Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular linksSeminars in Cancer Biology2012781
8Regulation ofp53downstream genesSeminars in Cancer Biology1998756
9Epidemiology of nasopharyngeal carcinomaSeminars in Cancer Biology2002751
1014-3-3 proteins: A historic overviewSeminars in Cancer Biology2006716
11Pyruvate kinase type M2 and its role in tumor growth and spreadingSeminars in Cancer Biology2005691
12Myeloid suppressor cells in cancer: Recruitment, phenotype, properties, and mechanisms of immune suppressionSeminars in Cancer Biology2006690
13The significance of cancer cell expression of the chemokine receptor CXCR4Seminars in Cancer Biology2004687
14The p53–Mdm2 module and the ubiquitin systemSeminars in Cancer Biology2003665
15Matrix metalloproteinases in tumor invasion and metastasisSeminars in Cancer Biology2000656
16PI3K/Akt/mTOR inhibitors in cancer: At the bench and bedsideSeminars in Cancer Biology2019627
17Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?Seminars in Cancer Biology2005608
18Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell deathSeminars in Cancer Biology1993595
19Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesionSeminars in Cancer Biology2010592
20Sorting it out: Regulation of exosome loadingSeminars in Cancer Biology2014592
21Cancer-related inflammation: Common themes and therapeutic opportunitiesSeminars in Cancer Biology2012567
22Inflammation as a tumor promoter in cancer inductionSeminars in Cancer Biology2004556
23Ferroptosis is a type of autophagy-dependent cell deathSeminars in Cancer Biology2020552
24The secreted factors responsible for pre-metastatic niche formation: Old sayings and new thoughtsSeminars in Cancer Biology2011550
25Broad targeting of resistance to apoptosis in cancerSeminars in Cancer Biology2015535
26Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapySeminars in Cancer Biology2018534
27Environmental and chemical carcinogenesisSeminars in Cancer Biology2004522
28Epstein–Barr virus in the pathogenesis of NPCSeminars in Cancer Biology2002513
29Three-dimensional tissue culture models in cancer biologySeminars in Cancer Biology2005511
30Gene expression perturbation in vitro—A growing case for three-dimensional (3D) culture systemsSeminars in Cancer Biology2005505
31Is Akt the “Warburg kinase”?—Akt-energy metabolism interactions and oncogenesisSeminars in Cancer Biology2009497
32The Myc oncoprotein as a therapeutic target for human cancerSeminars in Cancer Biology2006486
33MicroRNAs and immunity: Novel players in the regulation of normal immune function and inflammationSeminars in Cancer Biology2008478
34The thioredoxin system in cancerSeminars in Cancer Biology2006471
35Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapySeminars in Cancer Biology2009471
36Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor-induced immune suppressionSeminars in Cancer Biology2012468
37Sustained proliferation in cancer: Mechanisms and novel therapeutic targetsSeminars in Cancer Biology2015468
38Metastatic heterogeneity of breast cancer: Molecular mechanism and potential therapeutic targetsSeminars in Cancer Biology2020460
39VEGFs, receptors and angiogenesisSeminars in Cancer Biology1999438
40The angiogenic switch in carcinogenesisSeminars in Cancer Biology2009438
41EMT as the ultimate survival mechanism of cancer cellsSeminars in Cancer Biology2012421
42From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapySeminars in Cancer Biology2017416
43Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulationSeminars in Cancer Biology2017414
44The physiological function of drug-transporting P-glycoproteinsSeminars in Cancer Biology1997413
45Immune suppression in cancer: Effects on immune cells, mechanisms and future therapeutic interventionSeminars in Cancer Biology2006410
46Regulation of cancer cell metabolism by hypoxia-inducible factor 1Seminars in Cancer Biology2009410
47Tissue invasion and metastasis: Molecular, biological and clinical perspectivesSeminars in Cancer Biology2015408
48Role of telomeres and telomerase in cancerSeminars in Cancer Biology2011407
49Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significanceSeminars in Cancer Biology2019394
50Critical determinants of metastasisSeminars in Cancer Biology2002391