| # | Title | Journal | Year | Citations |
|---|
| 1 | Predicting effective microRNA target sites in mammalian mRNAs | ELife | 2015 | 5,779 |
| 2 | New tools for automated high-resolution cryo-EM structure determination in RELION-3 | ELife | 2018 | 3,965 |
| 3 | The MR-Base platform supports systematic causal inference across the human phenome | ELife | 2018 | 3,639 |
| 4 | RNA-programmed genome editing in human cells | ELife | 2013 | 1,830 |
| 5 | Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus | ELife | 2012 | 1,621 |
| 6 | The Human Cell Atlas | ELife | 2017 | 1,547 |
| 7 | Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis | ELife | 2013 | 1,507 |
| 8 | The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus | ELife | 2015 | 1,428 |
| 9 | Extinction risk and conservation of the world’s sharks and rays | ELife | 2014 | 1,400 |
| 10 | Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis | ELife | 2014 | 1,296 |
| 11 | Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants | ELife | 2020 | 1,239 |
| 12 | The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications | ELife | 2020 | 1,191 |
| 13 | An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites | ELife | 2017 | 1,119 |
| 14 | Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development | ELife | 2017 | 1,027 |
| 15 | A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice | ELife | 2018 | 979 |
| 16 | Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery | ELife | 2014 | 968 |
| 17 | Ventromedial hypothalamic neurons control a defensive emotion state | ELife | 2015 | 926 |
| 18 | Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2 | ELife | 2016 | 919 |
| 19 | Collaboration gets the most out of software | ELife | 2013 | 869 |
| 20 | Consolidation alters motor sequence-specific distributed representations | ELife | 2019 | 863 |
| 21 | Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis | ELife | 2014 | 851 |
| 22 | The neuronal architecture of the mushroom body provides a logic for associative learning | ELife | 2014 | 833 |
| 23 | SARS-CoV-2 (COVID-19) by the numbers | ELife | 2020 | 826 |
| 24 | YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs | ELife | 2017 | 815 |
| 25 | Sensitive red protein calcium indicators for imaging neural activity | ELife | 2016 | 813 |
| 26 | Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3 | ELife | 2021 | 808 |
| 27 | Cohabiting family members share microbiota with one another and with their dogs | ELife | 2013 | 801 |
| 28 | Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data | ELife | 2017 | 795 |
| 29 | cisTEM, user-friendly software for single-particle image processing | ELife | 2018 | 792 |
| 30 | Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases | ELife | 2016 | 766 |
| 31 | Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6 | ELife | 2015 | 748 |
| 32 | Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism | ELife | 2016 | 681 |
| 33 | Concerning RNA-guided gene drives for the alteration of wild populations | ELife | 2014 | 653 |
| 34 | Unprecedented genomic diversity of RNA viruses in arthropods reveals the ancestry of negative-sense RNA viruses | ELife | 2015 | 629 |
| 35 | Multiple knockout mouse models reveal lincRNAs are required for life and brain development | ELife | 2013 | 609 |
| 36 | Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation | ELife | 2016 | 609 |
| 37 | In vitro generation of human pluripotent stem cell derived lung organoids | ELife | 2015 | 605 |
| 38 | Diverse stimuli engage different neutrophil extracellular trap pathways | ELife | 2017 | 598 |
| 39 | A connectome and analysis of the adult Drosophila central brain | ELife | 2020 | 596 |
| 40 | Distinct stages in stress granule assembly and disassembly | ELife | 2016 | 593 |
| 41 | Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila | ELife | 2014 | 576 |
| 42 | Robust and accurate prediction of residue–residue interactions across protein interfaces using evolutionary information | ELife | 2014 | 571 |
| 43 | Pi-Pi contacts are an overlooked protein feature relevant to phase separation | ELife | 2018 | 571 |
| 44 | Atomic structures of respiratory complex III2, complex IV, and supercomplex III2-IV from vascular plants | ELife | 2021 | 559 |
| 45 | Sampling the conformational space of the catalytic subunit of human γ-secretase | ELife | 2015 | 556 |
| 46 | CaImAn an open source tool for scalable calcium imaging data analysis | ELife | 2019 | 551 |
| 47 | Pharmacological brake-release of mRNA translation enhances cognitive memory | ELife | 2013 | 541 |
| 48 | Evolutionary dynamics of cancer in response to targeted combination therapy | ELife | 2013 | 516 |
| 49 | Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins | ELife | 2017 | 514 |
| 50 | A large field of view two-photon mesoscope with subcellular resolution for in vivo imaging | ELife | 2016 | 495 |
