| 1 | In vivo near-infrared fluorescence imaging | Current Opinion in Chemical Biology | 2003 | 2,548 |
| 2 | Interactions between macromolecules and ions: the Hofmeister series | Current Opinion in Chemical Biology | 2006 | 1,886 |
| 3 | Applications of carbon nanotubes in drug delivery | Current Opinion in Chemical Biology | 2005 | 1,825 |
| 4 | Privileged scaffolds for library design and drug discovery | Current Opinion in Chemical Biology | 2010 | 1,391 |
| 5 | New trends for metal complexes with anticancer activity | Current Opinion in Chemical Biology | 2008 | 1,246 |
| 6 | Near-infrared fluorescence: application to in vivo molecular imaging | Current Opinion in Chemical Biology | 2010 | 1,058 |
| 7 | Polyubiquitin chains: polymeric protein signals | Current Opinion in Chemical Biology | 2004 | 960 |
| 8 | New metal complexes as potential therapeutics | Current Opinion in Chemical Biology | 2003 | 903 |
| 9 | Protein chip technology | Current Opinion in Chemical Biology | 2003 | 878 |
| 10 | Metal–organic frameworks as potential drug carriers | Current Opinion in Chemical Biology | 2010 | 790 |
| 11 | NIR dyes for bioimaging applications | Current Opinion in Chemical Biology | 2010 | 734 |
| 12 | Metals and neuroscience | Current Opinion in Chemical Biology | 2000 | 720 |
| 13 | Molecular mechanisms of copper uptake and distribution | Current Opinion in Chemical Biology | 2002 | 687 |
| 14 | Cyclic peptide therapeutics: past, present and future | Current Opinion in Chemical Biology | 2017 | 685 |
| 15 | Metals in Alzheimer's and Parkinson's Diseases | Current Opinion in Chemical Biology | 2008 | 675 |
| 16 | Mass spectrometry for proteomics | Current Opinion in Chemical Biology | 2008 | 666 |
| 17 | The proprotein convertases | Current Opinion in Chemical Biology | 1998 | 648 |
| 18 | Antibody–drug conjugates: targeted drug delivery for cancer | Current Opinion in Chemical Biology | 2010 | 620 |
| 19 | Expanding the functional diversity of proteins through cysteine oxidation | Current Opinion in Chemical Biology | 2008 | 614 |
| 20 | Immobilised enzymes: science or art? | Current Opinion in Chemical Biology | 2005 | 608 |
| 21 | Polymers in drug delivery | Current Opinion in Chemical Biology | 2001 | 595 |
| 22 | Bioethanol | Current Opinion in Chemical Biology | 2006 | 594 |
| 23 | Lignocellulose degradation mechanisms across the Tree of Life | Current Opinion in Chemical Biology | 2015 | 591 |
| 24 | Nutritional immunity beyond iron: a role for manganese and zinc | Current Opinion in Chemical Biology | 2010 | 589 |
| 25 | Dendritic polymer macromolecular carriers for drug delivery | Current Opinion in Chemical Biology | 2002 | 581 |
| 26 | Enzyme promiscuity: evolutionary and mechanistic aspects | Current Opinion in Chemical Biology | 2006 | 578 |
| 27 | The impact of natural products upon modern drug discovery | Current Opinion in Chemical Biology | 2008 | 565 |
| 28 | G-quadruplex nucleic acids as therapeutic targets | Current Opinion in Chemical Biology | 2009 | 557 |
| 29 | Design of nanostructured biological materials through self-assembly of peptides and proteins | Current Opinion in Chemical Biology | 2002 | 550 |
| 30 | Folate-targeted therapeutic and imaging agents for cancer | Current Opinion in Chemical Biology | 2009 | 550 |
| 31 | Modification-specific proteomics: characterization of post-translational modifications by mass spectrometry | Current Opinion in Chemical Biology | 2004 | 546 |
| 32 | High-throughput screening: new technology for the 21st century | Current Opinion in Chemical Biology | 2000 | 542 |
| 33 | Synthetic multivalent ligands in the exploration of cell-surface interactions | Current Opinion in Chemical Biology | 2000 | 538 |
| 34 | Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms | Current Opinion in Chemical Biology | 2003 | 538 |
| 35 | Pursuing the leadlikeness concept in pharmaceutical research | Current Opinion in Chemical Biology | 2004 | 535 |
| 36 | Biological applications of dendrimers | Current Opinion in Chemical Biology | 2002 | 514 |
| 37 | Targeted protein degradation: elements of PROTAC design | Current Opinion in Chemical Biology | 2019 | 513 |
| 38 | Nanoparticles for bioanalysis | Current Opinion in Chemical Biology | 2003 | 507 |
| 39 | Enzymes with extra talents: moonlighting functions and catalytic promiscuity | Current Opinion in Chemical Biology | 2003 | 501 |
| 40 | Metal-based anticancer chemotherapeutic agents | Current Opinion in Chemical Biology | 2014 | 491 |
| 41 | Peptidomimetics, a synthetic tool of drug discovery | Current Opinion in Chemical Biology | 2008 | 490 |
| 42 | Recent advances in multicomponent reactions for diversity-oriented synthesis | Current Opinion in Chemical Biology | 2010 | 490 |
| 43 | Lipases as practical biocatalysts | Current Opinion in Chemical Biology | 2002 | 488 |
| 44 | Molecular beacons | Current Opinion in Chemical Biology | 2004 | 485 |
| 45 | Model membrane systems and their applications | Current Opinion in Chemical Biology | 2007 | 479 |
| 46 | The potential of organometallic complexes in medicinal chemistry | Current Opinion in Chemical Biology | 2012 | 475 |
| 47 | Glycosidase mechanisms | Current Opinion in Chemical Biology | 2000 | 474 |
| 48 | Enzymes from extremophiles | Current Opinion in Chemical Biology | 2001 | 473 |
| 49 | Lead discovery using molecular docking | Current Opinion in Chemical Biology | 2002 | 468 |
| 50 | Recent advances in isocyanide-based multicomponent chemistry | Current Opinion in Chemical Biology | 2002 | 466 |