| 1 | Characterisation of COPD heterogeneity in the ECLIPSE cohort | Respiratory Research | 2010 | 745 |
| 2 | TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT) | Respiratory Research | 2005 | 586 |
| 3 | Alveolar epithelial type II cell: defender of the alveolus revisited | Respiratory Research | 2001 | 547 |
| 4 | Global incidence and prevalence of idiopathic pulmonary fibrosis | Respiratory Research | 2021 | 456 |
| 5 | Role of TNFα in pulmonary pathophysiology | Respiratory Research | 2006 | 423 |
| 6 | Idiopathic pulmonary fibrosis: pathogenesis and management | Respiratory Research | 2018 | 423 |
| 7 | From SARS and MERS to COVID-19: a brief summary and comparison of severe acute respiratory infections caused by three highly pathogenic human coronaviruses | Respiratory Research | 2020 | 420 |
| 8 | IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? | Respiratory Research | 2006 | 405 |
| 9 | Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells | Respiratory Research | 2005 | 386 |
| 10 | Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema | Respiratory Research | 2006 | 379 |
| 11 | Impact of coronavirus disease 2019 on pulmonary function in early convalescence phase | Respiratory Research | 2020 | 366 |
| 12 | Tumor necrosis factor-α and muscle wasting: a cellular perspective | Respiratory Research | 2001 | 345 |
| 13 | Epithelial antimicrobial peptides in host defense against infection | Respiratory Research | 2000 | 331 |
| 14 | Th2 cytokines and asthma — Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists | Respiratory Research | 2001 | 331 |
| 15 | The pathophysiology of ‘happy’ hypoxemia in COVID-19 | Respiratory Research | 2020 | 328 |
| 16 | Exhaled volatile organic compounds in patients with non-small cell lung cancer: cross sectional and nested short-term follow-up study | Respiratory Research | 2005 | 312 |
| 17 | An updated overview of e-cigarette impact on human health | Respiratory Research | 2021 | 312 |
| 18 | Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study | Respiratory Research | 2014 | 299 |
| 19 | Macrophages: friend or foe in idiopathic pulmonary fibrosis? | Respiratory Research | 2018 | 297 |
| 20 | The lung as a route for systemic delivery of therapeutic proteins and peptides | Respiratory Research | 2001 | 296 |
| 22 | Muscarinic receptor signaling in the pathophysiology of asthma and COPD | Respiratory Research | 2006 | 291 |
| 23 | Understanding the impact of symptoms on the burden of COPD | Respiratory Research | 2017 | 290 |
| 24 | Lung ultrasound for the diagnosis of pneumonia in adults: a systematic review and meta-analysis | Respiratory Research | 2014 | 283 |
| 25 | Measuring the lung function in the mouse: the challenge of size | Respiratory Research | 2003 | 282 |
| 26 | Long-term air pollution exposure and living close to busy roads are associated with COPD in women | Respiratory Research | 2005 | 279 |
| 27 | Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene | Respiratory Research | 2014 | 279 |
| 28 | The clinical features of the overlap between COPD and asthma | Respiratory Research | 2011 | 277 |
| 29 | Critical inhaler errors in asthma and COPD: a systematic review of impact on health outcomes | Respiratory Research | 2018 | 265 |
| 30 | Regulation of alveolar macrophage death in acute lung inflammation | Respiratory Research | 2018 | 257 |
| 31 | Global, regional, and national burden of asthma and its attributable risk factors from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019 | Respiratory Research | 2023 | 245 |
| 32 | Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells | Respiratory Research | 2013 | 244 |
| 33 | Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses | Respiratory Research | 2007 | 233 |
| 35 | Role of matrix metalloproteinases in the pathogenesis of idiopathic pulmonary fibrosis | Respiratory Research | 2016 | 229 |
| 36 | The roles and regulation of the actin cytoskeleton, intermediate filaments and microtubules in smooth muscle cell migration | Respiratory Research | 2017 | 229 |
| 37 | Drug-induced interstitial lung disease: mechanisms and best diagnostic approaches | Respiratory Research | 2012 | 228 |
| 38 | Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice | Respiratory Research | 2009 | 222 |
| 39 | Epithelial mesenchymal transition (EMT): a universal process in lung diseases with implications for cystic fibrosis pathophysiology | Respiratory Research | 2018 | 220 |
| 40 | Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis | Respiratory Research | 2014 | 210 |
| 41 | Matrix metalloproteinases in lung biology | Respiratory Research | 2000 | 209 |
| 42 | Parental and household smoking and the increased risk of bronchitis, bronchiolitis and other lower respiratory infections in infancy: systematic review and meta-analysis | Respiratory Research | 2011 | 209 |
| 43 | Human lung cancer cells express functionally active Toll-like receptor 9 | Respiratory Research | 2005 | 202 |
| 44 | Efficacy of salmeterol/fluticasone propionate by GOLD stage of chronic obstructive pulmonary disease: analysis from the randomised, placebo-controlled TORCH study | Respiratory Research | 2009 | 202 |
| 45 | Interstitial lung disease associated with systemic sclerosis (SSc-ILD) | Respiratory Research | 2019 | 199 |
| 46 | Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells | Respiratory Research | 2006 | 194 |
| 47 | Skeletal muscle dysfunction in chronic obstructive pulmonary disease | Respiratory Research | 2001 | 193 |
| 48 | The European IPF registry (eurIPFreg): baseline characteristics and survival of patients with idiopathic pulmonary fibrosis | Respiratory Research | 2018 | 193 |
| 49 | Antifibrotic therapy for idiopathic pulmonary fibrosis: time to treat | Respiratory Research | 2019 | 190 |
| 50 | Reduction of exacerbations by the PDE4 inhibitor roflumilast - the importance of defining different subsets of patients with COPD | Respiratory Research | 2011 | 189 |
