| # | Title | Journal | Year | Citations |
|---|
| 1 | The blockade of immune checkpoints in cancer immunotherapy | Nature Reviews Cancer | 2012 | 10,874 |
| 2 | MicroRNA signatures in human cancers | Nature Reviews Cancer | 2006 | 7,008 |
| 3 | Oncomirs — microRNAs with a role in cancer | Nature Reviews Cancer | 2006 | 6,509 |
| 4 | Targeting HIF-1 for cancer therapy | Nature Reviews Cancer | 2003 | 6,111 |
| 5 | Epithelial–mesenchymal transitions in tumour progression | Nature Reviews Cancer | 2002 | 5,923 |
| 6 | Photodynamic therapy for cancer | Nature Reviews Cancer | 2003 | 5,585 |
| 7 | The phosphatidylinositol 3-Kinase–AKT pathway in human cancer | Nature Reviews Cancer | 2002 | 5,480 |
| 8 | New functions for the matrix metalloproteinases in cancer progression | Nature Reviews Cancer | 2002 | 5,365 |
| 9 | Multidrug resistance in cancer: role of ATP–dependent transporters | Nature Reviews Cancer | 2002 | 4,873 |
| 10 | Hypoxia — a key regulatory factor in tumour growth | Nature Reviews Cancer | 2002 | 4,590 |
| 11 | Why do cancers have high aerobic glycolysis? | Nature Reviews Cancer | 2004 | 4,181 |
| 12 | Cancer nanomedicine: progress, challenges and opportunities | Nature Reviews Cancer | 2017 | 4,153 |
| 13 | Cancer nanotechnology: opportunities and challenges | Nature Reviews Cancer | 2005 | 4,111 |
| 14 | Regulation of cancer cell metabolism | Nature Reviews Cancer | 2011 | 4,100 |
| 15 | 5-Fluorouracil: mechanisms of action and clinical strategies | Nature Reviews Cancer | 2003 | 4,015 |
| 16 | Fibroblasts in cancer | Nature Reviews Cancer | 2006 | 3,978 |
| 17 | The resurgence of platinum-based cancer chemotherapy | Nature Reviews Cancer | 2007 | 3,971 |
| 18 | The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited | Nature Reviews Cancer | 2003 | 3,962 |
| 19 | The immune contexture in human tumours: impact on clinical outcome | Nature Reviews Cancer | 2012 | 3,873 |
| 20 | Microtubules as a target for anticancer drugs | Nature Reviews Cancer | 2004 | 3,823 |
| 21 | Cancer drug resistance: an evolving paradigm | Nature Reviews Cancer | 2013 | 3,667 |
| 22 | STATs in cancer inflammation and immunity: a leading role for STAT3 | Nature Reviews Cancer | 2009 | 3,503 |
| 23 | The Bcl2 family: regulators of the cellular life-or-death switch | Nature Reviews Cancer | 2002 | 3,457 |
| 24 | Dissemination and growth of cancer cells in metastatic sites | Nature Reviews Cancer | 2002 | 3,414 |
| 25 | Tumour stem cells and drug resistance | Nature Reviews Cancer | 2005 | 3,360 |
| 26 | Papillomaviruses and cancer: from basic studies to clinical application | Nature Reviews Cancer | 2002 | 3,356 |
| 27 | Microenvironmental regulation of metastasis | Nature Reviews Cancer | 2009 | 3,157 |
| 28 | Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms | Nature Reviews Cancer | 2004 | 3,092 |
| 29 | Cancer stem cells in solid tumours: accumulating evidence and unresolved questions | Nature Reviews Cancer | 2008 | 3,070 |
| 30 | Cell cycle, CDKs and cancer: a changing paradigm | Nature Reviews Cancer | 2009 | 3,070 |
| 31 | Tumorigenesis and the angiogenic switch | Nature Reviews Cancer | 2003 | 3,059 |
| 32 | Integrins in cancer: biological implications and therapeutic opportunities | Nature Reviews Cancer | 2010 | 3,045 |
| 33 | Tumour-educated macrophages promote tumour progression and metastasis | Nature Reviews Cancer | 2004 | 2,971 |
| 34 | Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits | Nature Reviews Cancer | 2009 | 2,951 |
| 35 | ERBB receptors and cancer: the complexity of targeted inhibitors | Nature Reviews Cancer | 2005 | 2,930 |
| 36 | Live or let die: the cell's response to p53 | Nature Reviews Cancer | 2002 | 2,906 |
| 37 | The biology and function of fibroblasts in cancer | Nature Reviews Cancer | 2016 | 2,886 |
| 38 | A census of human cancer genes | Nature Reviews Cancer | 2004 | 2,868 |
| 39 | Targeting RAS signalling pathways in cancer therapy | Nature Reviews Cancer | 2003 | 2,800 |
| 40 | Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? | Nature Reviews Cancer | 2007 | 2,796 |
| 41 | Tumour-cell invasion and migration: diversity and escape mechanisms | Nature Reviews Cancer | 2003 | 2,757 |
| 42 | Epidermal growth factor receptor mutations in lung cancer | Nature Reviews Cancer | 2007 | 2,741 |
| 43 | Targeting hypoxia in cancer therapy | Nature Reviews Cancer | 2011 | 2,607 |
| 44 | Modes of resistance to anti-angiogenic therapy | Nature Reviews Cancer | 2008 | 2,603 |
| 45 | Otto Warburg's contributions to current concepts of cancer metabolism | Nature Reviews Cancer | 2011 | 2,566 |
| 46 | Cancer chemoprevention with dietary phytochemicals | Nature Reviews Cancer | 2003 | 2,533 |
| 47 | Metastasis to bone: causes, consequences and therapeutic opportunities | Nature Reviews Cancer | 2002 | 2,498 |
| 48 | A decade of exploring the cancer epigenome — biological and translational implications | Nature Reviews Cancer | 2011 | 2,425 |
| 49 | Exploiting tumour hypoxia in cancer treatment | Nature Reviews Cancer | 2004 | 2,406 |
| 50 | Cell-free nucleic acids as biomarkers in cancer patients | Nature Reviews Cancer | 2011 | 2,372 |
