| # | Title | Journal | Year | Citations |
|---|
| 1 | Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement | PLoS Medicine | 2009 | 50,671 |
| 2 | The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration | PLoS Medicine | 2009 | 13,772 |
| 3 | Projections of Global Mortality and Burden of Disease from 2002 to 2030 | PLoS Medicine | 2006 | 8,440 |
| 4 | The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies | PLoS Medicine | 2007 | 7,961 |
| 5 | Why Most Published Research Findings Are False | PLoS Medicine | 2005 | 7,171 |
| 6 | UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age | PLoS Medicine | 2015 | 6,753 |
| 7 | Social Relationships and Mortality Risk: A Meta-analytic Review | PLoS Medicine | 2010 | 4,743 |
| 8 | Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration | PLoS Medicine | 2007 | 3,710 |
| 9 | Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain | PLoS Medicine | 2005 | 3,022 |
| 10 | The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) Statement | PLoS Medicine | 2015 | 2,892 |
| 11 | Burden of Depressive Disorders by Country, Sex, Age, and Year: Findings from the Global Burden of Disease Study 2010 | PLoS Medicine | 2013 | 2,377 |
| 12 | The Long-Term Health Consequences of Child Physical Abuse, Emotional Abuse, and Neglect: A Systematic Review and Meta-Analysis | PLoS Medicine | 2012 | 2,365 |
| 13 | Social Contacts and Mixing Patterns Relevant to the Spread of Infectious Diseases | PLoS Medicine | 2008 | 2,355 |
| 14 | Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial | PLoS Medicine | 2005 | 1,937 |
| 15 | Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration | PLoS Medicine | 2008 | 1,935 |
| 16 | Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index | PLoS Medicine | 2004 | 1,839 |
| 17 | A Systematic Review of the Prevalence of Schizophrenia | PLoS Medicine | 2005 | 1,606 |
| 18 | The Preventable Causes of Death in the United States: Comparative Risk Assessment of Dietary, Lifestyle, and Metabolic Risk Factors | PLoS Medicine | 2009 | 1,529 |
| 19 | National, Regional, and Global Trends in Infertility Prevalence Since 1990: A Systematic Analysis of 277 Health Surveys | PLoS Medicine | 2012 | 1,484 |
| 20 | The Effectiveness of Mobile-Health Technology-Based Health Behaviour Change or Disease Management Interventions for Health Care Consumers: A Systematic Review | PLoS Medicine | 2013 | 1,406 |
| 21 | Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection | PLoS Medicine | 2008 | 1,398 |
| 22 | The Global Burden of Snakebite: A Literature Analysis and Modelling Based on Regional Estimates of Envenoming and Deaths | PLoS Medicine | 2008 | 1,342 |
| 23 | The PRISMA 2020 statement: An updated guideline for reporting systematic reviews | PLoS Medicine | 2021 | 1,340 |
| 24 | KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib | PLoS Medicine | 2005 | 1,331 |
| 25 | Prolonged Grief Disorder: Psychometric Validation of Criteria Proposed for DSM-V and ICD-11 | PLoS Medicine | 2009 | 1,320 |
| 26 | The Global Burden of Latent Tuberculosis Infection: A Re-estimation Using Mathematical Modelling | PLoS Medicine | 2016 | 1,305 |
| 27 | Preoperative/Neoadjuvant Therapy in Pancreatic Cancer: A Systematic Review and Meta-analysis of Response and Resection Percentages | PLoS Medicine | 2010 | 1,300 |
| 28 | World Health Organization Global Estimates and Regional Comparisons of the Burden of Foodborne Disease in 2010 | PLoS Medicine | 2015 | 1,250 |
| 29 | MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia | PLoS Medicine | 2006 | 1,222 |
| 30 | Sleep-Disordered Breathing and Mortality: A Prospective Cohort Study | PLoS Medicine | 2009 | 1,149 |
| 31 | CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials | PLoS Medicine | 2010 | 1,135 |
| 32 | Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value | PLoS Medicine | 2013 | 1,064 |
| 33 | The Impact of eHealth on the Quality and Safety of Health Care: A Systematic Overview | PLoS Medicine | 2011 | 1,052 |
| 34 | Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies: The CHARMS Checklist | PLoS Medicine | 2014 | 1,036 |
| 35 | Diabetes Mellitus Increases the Risk of Active Tuberculosis: A Systematic Review of 13 Observational Studies | PLoS Medicine | 2008 | 1,028 |
| 36 | Can Animal Models of Disease Reliably Inform Human Studies? | PLoS Medicine | 2010 | 1,026 |
| 37 | Prognosis Research Strategy (PROGRESS) 3: Prognostic Model Research | PLoS Medicine | 2013 | 1,006 |
| 38 | SARS: Systematic Review of Treatment Effects | PLoS Medicine | 2006 | 994 |
| 39 | Predicting Outcome after Traumatic Brain Injury: Development and International Validation of Prognostic Scores Based on Admission Characteristics | PLoS Medicine | 2008 | 993 |
| 40 | Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak | PLoS Medicine | 2006 | 967 |
| 41 | World Health Organization Estimates of the Global and Regional Disease Burden of 22 Foodborne Bacterial, Protozoal, and Viral Diseases, 2010: A Data Synthesis | PLoS Medicine | 2015 | 937 |
| 42 | Effects on Coronary Heart Disease of Increasing Polyunsaturated Fat in Place of Saturated Fat: A Systematic Review and Meta-Analysis of Randomized Controlled Trials | PLoS Medicine | 2010 | 934 |
| 43 | Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050? | PLoS Medicine | 2016 | 929 |
| 44 | Guidance for Developers of Health Research Reporting Guidelines | PLoS Medicine | 2010 | 905 |
| 45 | Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer | PLoS Medicine | 2006 | 894 |
| 46 | The Mistreatment of Women during Childbirth in Health Facilities Globally: A Mixed-Methods Systematic Review | PLoS Medicine | 2015 | 883 |
| 47 | A Space–Time Permutation Scan Statistic for Disease Outbreak Detection | PLoS Medicine | 2005 | 882 |
| 48 | The Effectiveness of Mobile-Health Technologies to Improve Health Care Service Delivery Processes: A Systematic Review and Meta-Analysis | PLoS Medicine | 2013 | 853 |
| 49 | Intimate Partner Violence and Incident Depressive Symptoms and Suicide Attempts: A Systematic Review of Longitudinal Studies | PLoS Medicine | 2013 | 833 |
| 50 | Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: A living systematic review and meta-analysis | PLoS Medicine | 2020 | 833 |
