| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement | PLoS Medicine | 2009 | 52,826 |
| 2 | The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration | PLoS Medicine | 2009 | 14,265 |
| 3 | Projections of Global Mortality and Burden of Disease from 2002 to 2030 | PLoS Medicine | 2006 | 8,687 |
| 4 | The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies | PLoS Medicine | 2007 | 8,500 |
| 5 | UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age | PLoS Medicine | 2015 | 7,668 |
| 6 | Why Most Published Research Findings Are False | PLoS Medicine | 2005 | 7,524 |
| 7 | Social Relationships and Mortality Risk: A Meta-analytic Review | PLoS Medicine | 2010 | 4,994 |
| 8 | Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration | PLoS Medicine | 2007 | 4,006 |
| 9 | The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) Statement | PLoS Medicine | 2015 | 3,168 |
| 10 | Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain | PLoS Medicine | 2005 | 3,046 |
| 11 | The Long-Term Health Consequences of Child Physical Abuse, Emotional Abuse, and Neglect: A Systematic Review and Meta-Analysis | PLoS Medicine | 2012 | 2,474 |
| 12 | Burden of Depressive Disorders by Country, Sex, Age, and Year: Findings from the Global Burden of Disease Study 2010 | PLoS Medicine | 2013 | 2,469 |
| 13 | Social Contacts and Mixing Patterns Relevant to the Spread of Infectious Diseases | PLoS Medicine | 2008 | 2,438 |
| 14 | Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration | PLoS Medicine | 2008 | 1,963 |
| 15 | Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial | PLoS Medicine | 2005 | 1,950 |
| 16 | Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index | PLoS Medicine | 2004 | 1,886 |
| 17 | The PRISMA 2020 statement: An updated guideline for reporting systematic reviews | PLoS Medicine | 2021 | 1,623 |
| 18 | The Preventable Causes of Death in the United States: Comparative Risk Assessment of Dietary, Lifestyle, and Metabolic Risk Factors | PLoS Medicine | 2009 | 1,556 |
| 19 | National, Regional, and Global Trends in Infertility Prevalence Since 1990: A Systematic Analysis of 277 Health Surveys | PLoS Medicine | 2012 | 1,549 |
| 20 | The Global Burden of Latent Tuberculosis Infection: A Re-estimation Using Mathematical Modelling | PLoS Medicine | 2016 | 1,423 |
| 21 | Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection | PLoS Medicine | 2008 | 1,413 |
| 22 | The Global Burden of Snakebite: A Literature Analysis and Modelling Based on Regional Estimates of Envenoming and Deaths | PLoS Medicine | 2008 | 1,404 |
| 23 | Prolonged Grief Disorder: Psychometric Validation of Criteria Proposed for DSM-V and ICD-11 | PLoS Medicine | 2009 | 1,366 |
| 24 | Preoperative/Neoadjuvant Therapy in Pancreatic Cancer: A Systematic Review and Meta-analysis of Response and Resection Percentages | PLoS Medicine | 2010 | 1,344 |
| 25 | KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib | PLoS Medicine | 2005 | 1,342 |
| 26 | MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia | PLoS Medicine | 2006 | 1,236 |
| 27 | CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials | PLoS Medicine | 2010 | 1,187 |
| 28 | Sleep-Disordered Breathing and Mortality: A Prospective Cohort Study | PLoS Medicine | 2009 | 1,180 |
| 29 | Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies: The CHARMS Checklist | PLoS Medicine | 2014 | 1,132 |
| 30 | Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value | PLoS Medicine | 2013 | 1,121 |
| 31 | The Impact of eHealth on the Quality and Safety of Health Care: A Systematic Overview | PLoS Medicine | 2011 | 1,078 |
| 32 | Diabetes Mellitus Increases the Risk of Active Tuberculosis: A Systematic Review of 13 Observational Studies | PLoS Medicine | 2008 | 1,064 |
| 33 | Prognosis Research Strategy (PROGRESS) 3: Prognostic Model Research | PLoS Medicine | 2013 | 1,059 |
| 34 | Can Animal Models of Disease Reliably Inform Human Studies? | PLoS Medicine | 2010 | 1,055 |
| 35 | Predicting Outcome after Traumatic Brain Injury: Development and International Validation of Prognostic Scores Based on Admission Characteristics | PLoS Medicine | 2008 | 1,041 |
| 36 | Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050? | PLoS Medicine | 2016 | 1,030 |
| 37 | SARS: Systematic Review of Treatment Effects | PLoS Medicine | 2006 | 1,009 |
| 38 | World Health Organization Estimates of the Global and Regional Disease Burden of 22 Foodborne Bacterial, Protozoal, and Viral Diseases, 2010: A Data Synthesis | PLoS Medicine | 2015 | 992 |
| 39 | Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak | PLoS Medicine | 2006 | 980 |
| 40 | Guidance for Developers of Health Research Reporting Guidelines | PLoS Medicine | 2010 | 974 |
| 41 | Effects on Coronary Heart Disease of Increasing Polyunsaturated Fat in Place of Saturated Fat: A Systematic Review and Meta-Analysis of Randomized Controlled Trials | PLoS Medicine | 2010 | 956 |
| 42 | The Mistreatment of Women during Childbirth in Health Facilities Globally: A Mixed-Methods Systematic Review | PLoS Medicine | 2015 | 938 |
| 43 | Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer | PLoS Medicine | 2006 | 912 |
| 44 | A Space–Time Permutation Scan Statistic for Disease Outbreak Detection | PLoS Medicine | 2005 | 910 |
| 45 | The Effectiveness of Mobile-Health Technologies to Improve Health Care Service Delivery Processes: A Systematic Review and Meta-Analysis | PLoS Medicine | 2013 | 881 |
| 46 | Intimate Partner Violence and Incident Depressive Symptoms and Suicide Attempts: A Systematic Review of Longitudinal Studies | PLoS Medicine | 2013 | 877 |
| 47 | Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: A living systematic review and meta-analysis | PLoS Medicine | 2020 | 873 |
| 48 | Schizophrenia and Violence: Systematic Review and Meta-Analysis | PLoS Medicine | 2009 | 862 |
| 49 | Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up? | PLoS Medicine | 2010 | 848 |
| 50 | Deep learning for chest radiograph diagnosis: A retrospective comparison of the CheXNeXt algorithm to practicing radiologists | PLoS Medicine | 2018 | 846 |
