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Top Articles

1Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA StatementPLoS Medicine200950,671
2The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and ElaborationPLoS Medicine200913,772
3Projections of Global Mortality and Burden of Disease from 2002 to 2030PLoS Medicine20068,440
4The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational StudiesPLoS Medicine20077,961
5Why Most Published Research Findings Are FalsePLoS Medicine20057,171
6UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old AgePLoS Medicine20156,753
7Social Relationships and Mortality Risk: A Meta-analytic ReviewPLoS Medicine20104,743
8Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and ElaborationPLoS Medicine20073,710
9Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase DomainPLoS Medicine20053,022
10The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) StatementPLoS Medicine20152,892
11Burden of Depressive Disorders by Country, Sex, Age, and Year: Findings from the Global Burden of Disease Study 2010PLoS Medicine20132,377
12The Long-Term Health Consequences of Child Physical Abuse, Emotional Abuse, and Neglect: A Systematic Review and Meta-AnalysisPLoS Medicine20122,365
13Social Contacts and Mixing Patterns Relevant to the Spread of Infectious DiseasesPLoS Medicine20082,355
14Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 TrialPLoS Medicine20051,937
15Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug AdministrationPLoS Medicine20081,935
16Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass IndexPLoS Medicine20041,839
17A Systematic Review of the Prevalence of SchizophreniaPLoS Medicine20051,606
18The Preventable Causes of Death in the United States: Comparative Risk Assessment of Dietary, Lifestyle, and Metabolic Risk FactorsPLoS Medicine20091,529
19National, Regional, and Global Trends in Infertility Prevalence Since 1990: A Systematic Analysis of 277 Health SurveysPLoS Medicine20121,484
20The Effectiveness of Mobile-Health Technology-Based Health Behaviour Change or Disease Management Interventions for Health Care Consumers: A Systematic ReviewPLoS Medicine20131,406
21Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV InfectionPLoS Medicine20081,398
22The Global Burden of Snakebite: A Literature Analysis and Modelling Based on Regional Estimates of Envenoming and DeathsPLoS Medicine20081,342
23The PRISMA 2020 statement: An updated guideline for reporting systematic reviewsPLoS Medicine20211,340
24KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or ErlotinibPLoS Medicine20051,331
25Prolonged Grief Disorder: Psychometric Validation of Criteria Proposed for DSM-V and ICD-11PLoS Medicine20091,320
26The Global Burden of Latent Tuberculosis Infection: A Re-estimation Using Mathematical ModellingPLoS Medicine20161,305
27Preoperative/Neoadjuvant Therapy in Pancreatic Cancer: A Systematic Review and Meta-analysis of Response and Resection PercentagesPLoS Medicine20101,300
28World Health Organization Global Estimates and Regional Comparisons of the Burden of Foodborne Disease in 2010PLoS Medicine20151,250
29MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid MetaplasiaPLoS Medicine20061,222
30Sleep-Disordered Breathing and Mortality: A Prospective Cohort StudyPLoS Medicine20091,149
31CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised TrialsPLoS Medicine20101,135
32Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic ValuePLoS Medicine20131,064
33The Impact of eHealth on the Quality and Safety of Health Care: A Systematic OverviewPLoS Medicine20111,052
34Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies: The CHARMS ChecklistPLoS Medicine20141,036
35Diabetes Mellitus Increases the Risk of Active Tuberculosis: A Systematic Review of 13 Observational StudiesPLoS Medicine20081,028
36Can Animal Models of Disease Reliably Inform Human Studies?PLoS Medicine20101,026
37Prognosis Research Strategy (PROGRESS) 3: Prognostic Model ResearchPLoS Medicine20131,006
38SARS: Systematic Review of Treatment EffectsPLoS Medicine2006994
39Predicting Outcome after Traumatic Brain Injury: Development and International Validation of Prognostic Scores Based on Admission CharacteristicsPLoS Medicine2008993
40Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean OutbreakPLoS Medicine2006967
41World Health Organization Estimates of the Global and Regional Disease Burden of 22 Foodborne Bacterial, Protozoal, and Viral Diseases, 2010: A Data SynthesisPLoS Medicine2015937
42Effects on Coronary Heart Disease of Increasing Polyunsaturated Fat in Place of Saturated Fat: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsPLoS Medicine2010934
43Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050?PLoS Medicine2016929
44Guidance for Developers of Health Research Reporting GuidelinesPLoS Medicine2010905
45Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung CancerPLoS Medicine2006894
46The Mistreatment of Women during Childbirth in Health Facilities Globally: A Mixed-Methods Systematic ReviewPLoS Medicine2015883
47A Space–Time Permutation Scan Statistic for Disease Outbreak DetectionPLoS Medicine2005882
48The Effectiveness of Mobile-Health Technologies to Improve Health Care Service Delivery Processes: A Systematic Review and Meta-AnalysisPLoS Medicine2013853
49Intimate Partner Violence and Incident Depressive Symptoms and Suicide Attempts: A Systematic Review of Longitudinal StudiesPLoS Medicine2013833
50Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: A living systematic review and meta-analysisPLoS Medicine2020833