| # | Title | Journal | Year | Citations |
|---|
|
| 1 | RNA-Seq: a revolutionary tool for transcriptomics | Nature Reviews Genetics | 2009 | 10,838 |
| 2 | Network biology: understanding the cell's functional organization | Nature Reviews Genetics | 2004 | 6,830 |
| 3 | MicroRNAs: small RNAs with a big role in gene regulation | Nature Reviews Genetics | 2004 | 6,279 |
| 4 | Sequencing technologies — the next generation | Nature Reviews Genetics | 2010 | 6,060 |
| 5 | Long non-coding RNAs: insights into functions | Nature Reviews Genetics | 2009 | 5,206 |
| 6 | Functions of DNA methylation: islands, start sites, gene bodies and beyond | Nature Reviews Genetics | 2012 | 5,014 |
| 7 | The fundamental role of epigenetic events in cancer | Nature Reviews Genetics | 2002 | 4,929 |
| 8 | Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? | Nature Reviews Genetics | 2008 | 4,655 |
| 9 | Non-coding RNAs in human disease | Nature Reviews Genetics | 2011 | 4,269 |
| 10 | The widespread regulation of microRNA biogenesis, function and decay | Nature Reviews Genetics | 2010 | 4,138 |
| 11 | Network medicine: a network-based approach to human disease | Nature Reviews Genetics | 2011 | 4,108 |
| 12 | Insights into the regulation of protein abundance from proteomic and transcriptomic analyses | Nature Reviews Genetics | 2012 | 3,343 |
| 13 | Coming of age: ten years of next-generation sequencing technologies | Nature Reviews Genetics | 2016 | 3,335 |
| 14 | Establishing, maintaining and modifying DNA methylation patterns in plants and animals | Nature Reviews Genetics | 2010 | 3,308 |
| 15 | The biogenesis, biology and characterization of circular RNAs | Nature Reviews Genetics | 2019 | 3,094 |
| 16 | Unique features of long non-coding RNA biogenesis and function | Nature Reviews Genetics | 2016 | 3,031 |
| 17 | The human microbiome: at the interface of health and disease | Nature Reviews Genetics | 2012 | 2,903 |
| 18 | The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism | Nature Reviews Genetics | 2006 | 2,899 |
| 19 | Plant immunity: towards an integrated view of plant–pathogen interactions | Nature Reviews Genetics | 2010 | 2,889 |
| 20 | Network motifs: theory and experimental approaches | Nature Reviews Genetics | 2007 | 2,847 |
| 21 | Causes and consequences of microRNA dysregulation in cancer | Nature Reviews Genetics | 2009 | 2,827 |
| 22 | Genome-wide association studies for common diseases and complex traits | Nature Reviews Genetics | 2005 | 2,745 |
| 23 | Long non-coding RNAs: new players in cell differentiation and development | Nature Reviews Genetics | 2014 | 2,677 |
| 24 | DNA methylation landscapes: provocative insights from epigenomics | Nature Reviews Genetics | 2008 | 2,668 |
| 25 | Non-viral vectors for gene-based therapy | Nature Reviews Genetics | 2014 | 2,659 |
| 26 | DNA methylation: roles in mammalian development | Nature Reviews Genetics | 2013 | 2,608 |
| 27 | Genome-wide association studies for complex traits: consensus, uncertainty and challenges | Nature Reviews Genetics | 2008 | 2,523 |
| 28 | DNA methylation and human disease | Nature Reviews Genetics | 2005 | 2,511 |
| 29 | A unified classification system for eukaryotic transposable elements | Nature Reviews Genetics | 2007 | 2,494 |
| 30 | Progress and problems with the use of viral vectors for gene therapy | Nature Reviews Genetics | 2003 | 2,260 |
| 31 | Genome-wide genetic marker discovery and genotyping using next-generation sequencing | Nature Reviews Genetics | 2011 | 2,244 |
| 32 | The many roles of histone deacetylases in development and physiology: implications for disease and therapy | Nature Reviews Genetics | 2009 | 2,217 |
| 33 | Environmental epigenomics and disease susceptibility | Nature Reviews Genetics | 2007 | 2,212 |
| 34 | Small silencing RNAs: an expanding universe | Nature Reviews Genetics | 2009 | 2,168 |
| 35 | To err (meiotically) is human: the genesis of human aneuploidy | Nature Reviews Genetics | 2001 | 2,163 |
| 36 | Genomic imprinting: parental influence on the genome | Nature Reviews Genetics | 2001 | 2,132 |
| 37 | Chromosome territories, nuclear architecture and gene regulation in mammalian cells | Nature Reviews Genetics | 2001 | 2,103 |
| 38 | Stochasticity in gene expression: from theories to phenotypes | Nature Reviews Genetics | 2005 | 2,103 |
| 39 | The molecular hallmarks of epigenetic control | Nature Reviews Genetics | 2016 | 2,076 |
| 40 | Gene silencing by microRNAs: contributions of translational repression and mRNA decay | Nature Reviews Genetics | 2011 | 2,054 |
| 41 | The advantages and disadvantages of being polyploid | Nature Reviews Genetics | 2005 | 2,021 |
| 42 | Linking DNA methylation and histone modification: patterns and paradigms | Nature Reviews Genetics | 2009 | 1,983 |
| 43 | Biological robustness | Nature Reviews Genetics | 2004 | 1,975 |
| 44 | DNA methylation-based biomarkers and the epigenetic clock theory of ageing | Nature Reviews Genetics | 2018 | 1,955 |
| 45 | Cancer epigenomics: DNA methylomes and histone-modification maps | Nature Reviews Genetics | 2007 | 1,945 |
| 46 | Listening to silence and understanding nonsense: exonic mutations that affect splicing | Nature Reviews Genetics | 2002 | 1,936 |
| 47 | Genome editing with engineered zinc finger nucleases | Nature Reviews Genetics | 2010 | 1,915 |
| 48 | Transcriptional architecture of the mammalian circadian clock | Nature Reviews Genetics | 2017 | 1,911 |
| 49 | Neuronal specification in the spinal cord: inductive signals and transcriptional codes | Nature Reviews Genetics | 2000 | 1,893 |
| 50 | Microsatellites: simple sequences with complex evolution | Nature Reviews Genetics | 2004 | 1,893 |
