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Top Articles

1RNA-Seq: a revolutionary tool for transcriptomicsNature Reviews Genetics200910,529
2Network biology: understanding the cell's functional organizationNature Reviews Genetics20046,726
3MicroRNAs: small RNAs with a big role in gene regulationNature Reviews Genetics20046,186
4Sequencing technologies — the next generationNature Reviews Genetics20105,942
5Long non-coding RNAs: insights into functionsNature Reviews Genetics20095,105
6The fundamental role of epigenetic events in cancerNature Reviews Genetics20024,872
7Functions of DNA methylation: islands, start sites, gene bodies and beyondNature Reviews Genetics20124,840
8Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?Nature Reviews Genetics20084,577
9Non-coding RNAs in human diseaseNature Reviews Genetics20114,159
10The widespread regulation of microRNA biogenesis, function and decayNature Reviews Genetics20104,038
11Network medicine: a network-based approach to human diseaseNature Reviews Genetics20113,987
12Insights into the regulation of protein abundance from proteomic and transcriptomic analysesNature Reviews Genetics20123,228
13Establishing, maintaining and modifying DNA methylation patterns in plants and animalsNature Reviews Genetics20103,201
14Coming of age: ten years of next-generation sequencing technologiesNature Reviews Genetics20163,160
15Unique features of long non-coding RNA biogenesis and functionNature Reviews Genetics20162,891
16The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolismNature Reviews Genetics20062,833
17The biogenesis, biology and characterization of circular RNAsNature Reviews Genetics20192,832
18The human microbiome: at the interface of health and diseaseNature Reviews Genetics20122,798
19Causes and consequences of microRNA dysregulation in cancerNature Reviews Genetics20092,791
20Plant immunity: towards an integrated view of plant–pathogen interactionsNature Reviews Genetics20102,790
21Network motifs: theory and experimental approachesNature Reviews Genetics20072,789
22Genome-wide association studies for common diseases and complex traitsNature Reviews Genetics20052,717
23DNA methylation landscapes: provocative insights from epigenomicsNature Reviews Genetics20082,619
24Long non-coding RNAs: new players in cell differentiation and developmentNature Reviews Genetics20142,616
25Non-viral vectors for gene-based therapyNature Reviews Genetics20142,572
26DNA methylation: roles in mammalian developmentNature Reviews Genetics20132,541
27Genome-wide association studies for complex traits: consensus, uncertainty and challengesNature Reviews Genetics20082,496
28DNA methylation and human diseaseNature Reviews Genetics20052,449
29A unified classification system for eukaryotic transposable elementsNature Reviews Genetics20072,396
30Progress and problems with the use of viral vectors for gene therapyNature Reviews Genetics20032,213
31Genome-wide genetic marker discovery and genotyping using next-generation sequencingNature Reviews Genetics20112,198
32Environmental epigenomics and disease susceptibilityNature Reviews Genetics20072,180
33The many roles of histone deacetylases in development and physiology: implications for disease and therapyNature Reviews Genetics20092,173
34Small silencing RNAs: an expanding universeNature Reviews Genetics20092,142
35Genomic imprinting: parental influence on the genomeNature Reviews Genetics20012,120
36To err (meiotically) is human: the genesis of human aneuploidyNature Reviews Genetics20012,118
37Stochasticity in gene expression: from theories to phenotypesNature Reviews Genetics20052,066
38Chromosome territories, nuclear architecture and gene regulation in mammalian cellsNature Reviews Genetics20012,056
39Gene silencing by microRNAs: contributions of translational repression and mRNA decayNature Reviews Genetics20112,009
40The advantages and disadvantages of being polyploidNature Reviews Genetics20051,950
41The molecular hallmarks of epigenetic controlNature Reviews Genetics20161,945
42Linking DNA methylation and histone modification: patterns and paradigmsNature Reviews Genetics20091,944
43Biological robustnessNature Reviews Genetics20041,937
44Listening to silence and understanding nonsense: exonic mutations that affect splicingNature Reviews Genetics20021,923
45Cancer epigenomics: DNA methylomes and histone-modification mapsNature Reviews Genetics20071,916
46Neuronal specification in the spinal cord: inductive signals and transcriptional codesNature Reviews Genetics20001,878
47Genome editing with engineered zinc finger nucleasesNature Reviews Genetics20101,863
48Microsatellites: simple sequences with complex evolutionNature Reviews Genetics20041,854
49Animal models of human disease: zebrafish swim into viewNature Reviews Genetics20071,829
50RNA sequencing: advances, challenges and opportunitiesNature Reviews Genetics20111,770