| # | Title | Journal | Year | Citations |
|---|
| 1 | RNA-Seq: a revolutionary tool for transcriptomics | Nature Reviews Genetics | 2009 | 10,529 |
| 2 | Network biology: understanding the cell's functional organization | Nature Reviews Genetics | 2004 | 6,726 |
| 3 | MicroRNAs: small RNAs with a big role in gene regulation | Nature Reviews Genetics | 2004 | 6,186 |
| 4 | Sequencing technologies — the next generation | Nature Reviews Genetics | 2010 | 5,942 |
| 5 | Long non-coding RNAs: insights into functions | Nature Reviews Genetics | 2009 | 5,105 |
| 6 | The fundamental role of epigenetic events in cancer | Nature Reviews Genetics | 2002 | 4,872 |
| 7 | Functions of DNA methylation: islands, start sites, gene bodies and beyond | Nature Reviews Genetics | 2012 | 4,840 |
| 8 | Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? | Nature Reviews Genetics | 2008 | 4,577 |
| 9 | Non-coding RNAs in human disease | Nature Reviews Genetics | 2011 | 4,159 |
| 10 | The widespread regulation of microRNA biogenesis, function and decay | Nature Reviews Genetics | 2010 | 4,038 |
| 11 | Network medicine: a network-based approach to human disease | Nature Reviews Genetics | 2011 | 3,987 |
| 12 | Insights into the regulation of protein abundance from proteomic and transcriptomic analyses | Nature Reviews Genetics | 2012 | 3,228 |
| 13 | Establishing, maintaining and modifying DNA methylation patterns in plants and animals | Nature Reviews Genetics | 2010 | 3,201 |
| 14 | Coming of age: ten years of next-generation sequencing technologies | Nature Reviews Genetics | 2016 | 3,160 |
| 15 | Unique features of long non-coding RNA biogenesis and function | Nature Reviews Genetics | 2016 | 2,891 |
| 16 | The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism | Nature Reviews Genetics | 2006 | 2,833 |
| 17 | The biogenesis, biology and characterization of circular RNAs | Nature Reviews Genetics | 2019 | 2,832 |
| 18 | The human microbiome: at the interface of health and disease | Nature Reviews Genetics | 2012 | 2,798 |
| 19 | Causes and consequences of microRNA dysregulation in cancer | Nature Reviews Genetics | 2009 | 2,791 |
| 20 | Plant immunity: towards an integrated view of plant–pathogen interactions | Nature Reviews Genetics | 2010 | 2,790 |
| 21 | Network motifs: theory and experimental approaches | Nature Reviews Genetics | 2007 | 2,789 |
| 22 | Genome-wide association studies for common diseases and complex traits | Nature Reviews Genetics | 2005 | 2,717 |
| 23 | DNA methylation landscapes: provocative insights from epigenomics | Nature Reviews Genetics | 2008 | 2,619 |
| 24 | Long non-coding RNAs: new players in cell differentiation and development | Nature Reviews Genetics | 2014 | 2,616 |
| 25 | Non-viral vectors for gene-based therapy | Nature Reviews Genetics | 2014 | 2,572 |
| 26 | DNA methylation: roles in mammalian development | Nature Reviews Genetics | 2013 | 2,541 |
| 27 | Genome-wide association studies for complex traits: consensus, uncertainty and challenges | Nature Reviews Genetics | 2008 | 2,496 |
| 28 | DNA methylation and human disease | Nature Reviews Genetics | 2005 | 2,449 |
| 29 | A unified classification system for eukaryotic transposable elements | Nature Reviews Genetics | 2007 | 2,396 |
| 30 | Progress and problems with the use of viral vectors for gene therapy | Nature Reviews Genetics | 2003 | 2,213 |
| 31 | Genome-wide genetic marker discovery and genotyping using next-generation sequencing | Nature Reviews Genetics | 2011 | 2,198 |
| 32 | Environmental epigenomics and disease susceptibility | Nature Reviews Genetics | 2007 | 2,180 |
| 33 | The many roles of histone deacetylases in development and physiology: implications for disease and therapy | Nature Reviews Genetics | 2009 | 2,173 |
| 34 | Small silencing RNAs: an expanding universe | Nature Reviews Genetics | 2009 | 2,142 |
| 35 | Genomic imprinting: parental influence on the genome | Nature Reviews Genetics | 2001 | 2,120 |
| 36 | To err (meiotically) is human: the genesis of human aneuploidy | Nature Reviews Genetics | 2001 | 2,118 |
| 37 | Stochasticity in gene expression: from theories to phenotypes | Nature Reviews Genetics | 2005 | 2,066 |
| 38 | Chromosome territories, nuclear architecture and gene regulation in mammalian cells | Nature Reviews Genetics | 2001 | 2,056 |
| 39 | Gene silencing by microRNAs: contributions of translational repression and mRNA decay | Nature Reviews Genetics | 2011 | 2,009 |
| 40 | The advantages and disadvantages of being polyploid | Nature Reviews Genetics | 2005 | 1,950 |
| 41 | The molecular hallmarks of epigenetic control | Nature Reviews Genetics | 2016 | 1,945 |
| 42 | Linking DNA methylation and histone modification: patterns and paradigms | Nature Reviews Genetics | 2009 | 1,944 |
| 43 | Biological robustness | Nature Reviews Genetics | 2004 | 1,937 |
| 44 | Listening to silence and understanding nonsense: exonic mutations that affect splicing | Nature Reviews Genetics | 2002 | 1,923 |
| 45 | Cancer epigenomics: DNA methylomes and histone-modification maps | Nature Reviews Genetics | 2007 | 1,916 |
| 46 | Neuronal specification in the spinal cord: inductive signals and transcriptional codes | Nature Reviews Genetics | 2000 | 1,878 |
| 47 | Genome editing with engineered zinc finger nucleases | Nature Reviews Genetics | 2010 | 1,863 |
| 48 | Microsatellites: simple sequences with complex evolution | Nature Reviews Genetics | 2004 | 1,854 |
| 49 | Animal models of human disease: zebrafish swim into view | Nature Reviews Genetics | 2007 | 1,829 |
| 50 | RNA sequencing: advances, challenges and opportunities | Nature Reviews Genetics | 2011 | 1,770 |
