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Top Articles

#TitleJournalYearCitations
1Drug-like properties and the causes of poor solubility and poor permeabilityJournal of Pharmacological and Toxicological Methods20002,921
2HEK293 cell line: A vehicle for the expression of recombinant proteinsJournal of Pharmacological and Toxicological Methods2005528
3A method to perform direct transcutaneous intrathecal injection in ratsJournal of Pharmacological and Toxicological Methods1994455
4Morphological and biochemical characterization and analysis of apoptosisJournal of Pharmacological and Toxicological Methods1997407
5The utility of the minipig as an animal model in regulatory toxicologyJournal of Pharmacological and Toxicological Methods2010348
6The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progressJournal of Pharmacological and Toxicological Methods2016335
7Therapeutic applications of implantable drug delivery systemsJournal of Pharmacological and Toxicological Methods1998276
8Isolated heart perfusion according to Langendorff—Still viable in the new millenniumJournal of Pharmacological and Toxicological Methods2007270
9Animal models of inflammatory bowel diseaseJournal of Pharmacological and Toxicological Methods2004244
10Progress in predicting human ADME parameters in silicoJournal of Pharmacological and Toxicological Methods2000240
11Current methodologies used for evaluation of intestinal permeability and absorptionJournal of Pharmacological and Toxicological Methods2000239
12A novel method for the release and collection of dermal, glandular secretions from the skin of frogsJournal of Pharmacological and Toxicological Methods1992230
13An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panelJournal of Pharmacological and Toxicological Methods2016227
14Variability in the measurement of hERG potassium channel inhibition: Effects of temperature and stimulus patternJournal of Pharmacological and Toxicological Methods2004224
15An assessment of the elevated X-maze for studying anxiety and anxiety-modulating drugsJournal of Pharmacological and Toxicological Methods1993192
16HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitroJournal of Pharmacological and Toxicological Methods2011182
17Free radicals and the heartJournal of Pharmacological and Toxicological Methods1993178
18Evaluation of scavenging activity assessed by Co(II)/EDTA-induced luminol chemiluminescence and DPPH· (2,2-diphenyl-1-picrylhydrazyl) free radical assayJournal of Pharmacological and Toxicological Methods2000172
19Present and future in vitro approaches for drug metabolismJournal of Pharmacological and Toxicological Methods2000169
20Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugsJournal of Pharmacological and Toxicological Methods2008167
21Experimental diabetes induced by alloxan and streptozotocin: The current state of the artJournal of Pharmacological and Toxicological Methods2016167
22Use of telemetry to record electrocardiogram and heart rate in freely moving miceJournal of Pharmacological and Toxicological Methods1993166
23Fructose-induced hypertension in rats is concentration- and duration-dependentJournal of Pharmacological and Toxicological Methods1995166
24Zebrafish based assays for the assessment of cardiac, visual and gut function — potential safety screens for early drug discoveryJournal of Pharmacological and Toxicological Methods2008165
25The action potential and comparative pharmacology of stem cell-derived human cardiomyocytesJournal of Pharmacological and Toxicological Methods2010165
26A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytesJournal of Pharmacological and Toxicological Methods2017163
27Comparison of PrestoBlue and MTT assays of cellular viability in the assessment of anti-proliferative effects of plant extracts on human endothelial cellsJournal of Pharmacological and Toxicological Methods2014159
28The vascular systemJournal of Pharmacological and Toxicological Methods2000158
29Computational tools for fitting the Hill equation to dose–response curvesJournal of Pharmacological and Toxicological Methods2015156
30A zebrafish phenotypic assay for assessing drug-induced hepatotoxicityJournal of Pharmacological and Toxicological Methods2013154
31Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks™ HTJournal of Pharmacological and Toxicological Methods2006148
32MethadoneJournal of Pharmacological and Toxicological Methods1999147
33Muscle on a chip: In vitro contractility assays for smooth and striated muscleJournal of Pharmacological and Toxicological Methods2012147
34Use of lectins as diagnostic and therapeutic tools for cancerJournal of Pharmacological and Toxicological Methods1995144
35The power issue: determination of KB or Ki from IC50Journal of Pharmacological and Toxicological Methods2001143
36Neurotoxicity assessment using zebrafishJournal of Pharmacological and Toxicological Methods2007143
37Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trendsJournal of Pharmacological and Toxicological Methods2006142
38The object recognition task in rats and mice: A simple and rapid model in safety pharmacology to detect amnesic properties of a new chemical entityJournal of Pharmacological and Toxicological Methods2006142
39Matrix metalloproteinase activity assays: Importance of zymographyJournal of Pharmacological and Toxicological Methods2010138
40HERG-Lite®: A novel comprehensive high-throughput screen for drug-induced hERG riskJournal of Pharmacological and Toxicological Methods2005136
41Improvement of acquisition and analysis methods in multi-electrode array experiments with iPS cell-derived cardiomyocytesJournal of Pharmacological and Toxicological Methods2015135
42The influence of restraint on blood pressure in the ratJournal of Pharmacological and Toxicological Methods1997129
43Use of the viability reagent PrestoBlue in comparison with alamarBlue and MTT to assess the viability of human corneal epithelial cellsJournal of Pharmacological and Toxicological Methods2015129
44Characterization of renal ischemia-reperfusion injury in ratsJournal of Pharmacological and Toxicological Methods1997128
45Tissue water content in rats measured by desiccationJournal of Pharmacological and Toxicological Methods1997128
46The automated bioaerosol exposure system: Preclinical platform development and a respiratory dosimetry application with nonhuman primatesJournal of Pharmacological and Toxicological Methods2004127
47Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugsJournal of Pharmacological and Toxicological Methods2004127
48Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imagingJournal of Pharmacological and Toxicological Methods2016122
49Mapping pharmaceuticals in tissues using MALDI imaging mass spectrometryJournal of Pharmacological and Toxicological Methods2007121
50To protect peptide pharmaceuticals against peptidasesJournal of Pharmacological and Toxicological Methods2010117