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exaly
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Journals
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Journal of Pharmacological and Toxicological Methods
›
top-articles
Journal of Pharmacological and Toxicological Methods
0.9
(top 50%)
impact factor
2.9K
(top 10%)
papers
46.8K
(top 10%)
citations
85
(top 10%)
h
-index
0.9
(top 50%)
impact factor
4.8K
all documents
48.9K
doc citations
139
(top 5%)
g
-index
Top Articles
#
Title
Journal
Year
Citations
1
Drug-like properties and the causes of poor solubility and poor permeability
Journal of Pharmacological and Toxicological Methods
2000
2,921
2
HEK293 cell line: A vehicle for the expression of recombinant proteins
Journal of Pharmacological and Toxicological Methods
2005
528
3
A method to perform direct transcutaneous intrathecal injection in rats
Journal of Pharmacological and Toxicological Methods
1994
455
4
Morphological and biochemical characterization and analysis of apoptosis
Journal of Pharmacological and Toxicological Methods
1997
407
5
The utility of the minipig as an animal model in regulatory toxicology
Journal of Pharmacological and Toxicological Methods
2010
348
6
The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress
Journal of Pharmacological and Toxicological Methods
2016
335
7
Therapeutic applications of implantable drug delivery systems
Journal of Pharmacological and Toxicological Methods
1998
276
8
Isolated heart perfusion according to Langendorff—Still viable in the new millennium
Journal of Pharmacological and Toxicological Methods
2007
270
9
Animal models of inflammatory bowel disease
Journal of Pharmacological and Toxicological Methods
2004
244
10
Progress in predicting human ADME parameters in silico
Journal of Pharmacological and Toxicological Methods
2000
240
11
Current methodologies used for evaluation of intestinal permeability and absorption
Journal of Pharmacological and Toxicological Methods
2000
239
12
A novel method for the release and collection of dermal, glandular secretions from the skin of frogs
Journal of Pharmacological and Toxicological Methods
1992
230
13
An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel
Journal of Pharmacological and Toxicological Methods
2016
227
14
Variability in the measurement of hERG potassium channel inhibition: Effects of temperature and stimulus pattern
Journal of Pharmacological and Toxicological Methods
2004
224
15
An assessment of the elevated X-maze for studying anxiety and anxiety-modulating drugs
Journal of Pharmacological and Toxicological Methods
1993
192
16
HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro
Journal of Pharmacological and Toxicological Methods
2011
182
17
Free radicals and the heart
Journal of Pharmacological and Toxicological Methods
1993
178
18
Evaluation of scavenging activity assessed by Co(II)/EDTA-induced luminol chemiluminescence and DPPH· (2,2-diphenyl-1-picrylhydrazyl) free radical assay
Journal of Pharmacological and Toxicological Methods
2000
172
19
Present and future in vitro approaches for drug metabolism
Journal of Pharmacological and Toxicological Methods
2000
169
20
Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs
Journal of Pharmacological and Toxicological Methods
2008
167
21
Experimental diabetes induced by alloxan and streptozotocin: The current state of the art
Journal of Pharmacological and Toxicological Methods
2016
167
22
Use of telemetry to record electrocardiogram and heart rate in freely moving mice
Journal of Pharmacological and Toxicological Methods
1993
166
23
Fructose-induced hypertension in rats is concentration- and duration-dependent
Journal of Pharmacological and Toxicological Methods
1995
166
24
Zebrafish based assays for the assessment of cardiac, visual and gut function — potential safety screens for early drug discovery
Journal of Pharmacological and Toxicological Methods
2008
165
25
The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes
Journal of Pharmacological and Toxicological Methods
2010
165
26
A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes
Journal of Pharmacological and Toxicological Methods
2017
163
27
Comparison of PrestoBlue and MTT assays of cellular viability in the assessment of anti-proliferative effects of plant extracts on human endothelial cells
Journal of Pharmacological and Toxicological Methods
2014
159
28
The vascular system
Journal of Pharmacological and Toxicological Methods
2000
158
29
Computational tools for fitting the Hill equation to dose–response curves
Journal of Pharmacological and Toxicological Methods
2015
156
30
A zebrafish phenotypic assay for assessing drug-induced hepatotoxicity
Journal of Pharmacological and Toxicological Methods
2013
154
31
Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks™ HT
Journal of Pharmacological and Toxicological Methods
2006
148
32
Methadone
Journal of Pharmacological and Toxicological Methods
1999
147
33
Muscle on a chip: In vitro contractility assays for smooth and striated muscle
Journal of Pharmacological and Toxicological Methods
2012
147
34
Use of lectins as diagnostic and therapeutic tools for cancer
Journal of Pharmacological and Toxicological Methods
1995
144
35
The power issue: determination of KB or Ki from IC50
Journal of Pharmacological and Toxicological Methods
2001
143
36
Neurotoxicity assessment using zebrafish
Journal of Pharmacological and Toxicological Methods
2007
143
37
Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends
Journal of Pharmacological and Toxicological Methods
2006
142
38
The object recognition task in rats and mice: A simple and rapid model in safety pharmacology to detect amnesic properties of a new chemical entity
Journal of Pharmacological and Toxicological Methods
2006
142
39
Matrix metalloproteinase activity assays: Importance of zymography
Journal of Pharmacological and Toxicological Methods
2010
138
40
HERG-Lite®: A novel comprehensive high-throughput screen for drug-induced hERG risk
Journal of Pharmacological and Toxicological Methods
2005
136
41
Improvement of acquisition and analysis methods in multi-electrode array experiments with iPS cell-derived cardiomyocytes
Journal of Pharmacological and Toxicological Methods
2015
135
42
The influence of restraint on blood pressure in the rat
Journal of Pharmacological and Toxicological Methods
1997
129
43
Use of the viability reagent PrestoBlue in comparison with alamarBlue and MTT to assess the viability of human corneal epithelial cells
Journal of Pharmacological and Toxicological Methods
2015
129
44
Characterization of renal ischemia-reperfusion injury in rats
Journal of Pharmacological and Toxicological Methods
1997
128
45
Tissue water content in rats measured by desiccation
Journal of Pharmacological and Toxicological Methods
1997
128
46
The automated bioaerosol exposure system: Preclinical platform development and a respiratory dosimetry application with nonhuman primates
Journal of Pharmacological and Toxicological Methods
2004
127
47
Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs
Journal of Pharmacological and Toxicological Methods
2004
127
48
Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imaging
Journal of Pharmacological and Toxicological Methods
2016
122
49
Mapping pharmaceuticals in tissues using MALDI imaging mass spectrometry
Journal of Pharmacological and Toxicological Methods
2007
121
50
To protect peptide pharmaceuticals against peptidases
Journal of Pharmacological and Toxicological Methods
2010
117
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