4(top 4%)
Impact Factor
4.3(top 4%)
extended IF
176(top 1%)
H-Index
1.7K
authors
8.9K
papers
292.5K
citations
5.6K
citing journals
58.5K
citing authors

Most Cited Articles of Drug Metabolism and Disposition

TitleYearCitations
High absorption but very low bioavailability of oral resveratrol in humans20041.3K
Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene1974976
Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes1999825
Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios2004771
Acetaminophen-induced hepatotoxicity2003739
The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective2003667
The human intestinal cytochrome P450 "pie"2006666
Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite2010600
Biotransformation of curcumin through reduction and glucuronidation in mice1999596
Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties2003592
The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans2008545
Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells2006501
Apixaban metabolism and pharmacokinetics after oral administration to humans2009479
Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities2004461
Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines2007445
OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine1999445
Validated assays for human cytochrome P450 activities2004438
The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model2005408
Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities1991399
CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes2002376
Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions2007375
Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes1995372
Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A72002371
In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system2008367
Structure and stereochemistry of the active metabolite of clopidogrel2002366