| # | Title | Journal | Year | Citations |
|---|
| 1 | Toll-like receptors in innate immunity | International Immunology | 2004 | 2,786 |
| 2 | Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. | International Immunology | 1998 | 1,364 |
| 3 | The roles of TLRs, RLRs and NLRs in pathogen recognition | International Immunology | 2009 | 1,355 |
| 4 | Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes | International Immunology | 1996 | 1,316 |
| 5 | Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway | International Immunology | 2000 | 1,201 |
| 6 | Exosomal-like vesicles are present in human blood plasma | International Immunology | 2005 | 1,126 |
| 7 | Discrimination of bacterial lipoproteins by Toll-like receptor 6 | International Immunology | 2001 | 1,112 |
| 8 | PD-1 and PD-1 ligands: from discovery to clinical application | International Immunology | 2007 | 1,064 |
| 9 | Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice | International Immunology | 1993 | 988 |
| 10 | Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production | International Immunology | 2007 | 756 |
| 11 | Regulatory T cells: how do they suppress immune responses? | International Immunology | 2009 | 735 |
| 12 | Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice | International Immunology | 1997 | 726 |
| 13 | Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells | International Immunology | 2004 | 713 |
| 14 | Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine | International Immunology | 1999 | 665 |
| 15 | IL-6: from its discovery to clinical applications | International Immunology | 2010 | 664 |
| 16 | IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK Cells | International Immunology | 2008 | 550 |
| 17 | Inducible gene knockout of transcription factor recombination signal binding protein‐J reveals its essential role in T versus B lineage decision | International Immunology | 2002 | 533 |
| 18 | IL-6 in inflammation, autoimmunity and cancer | International Immunology | 2021 | 500 |
| 19 | Anti-TNF therapy: past, present and future | International Immunology | 2015 | 455 |
| 20 | Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system | International Immunology | 2008 | 451 |
| 21 | Activation interferes with the APO-1 pathway in mature human T cells | International Immunology | 1993 | 444 |
| 22 | Differences in promiscuity for antibody–FcRn interactions across species: implications for therapeutic antibodies | International Immunology | 2001 | 430 |
| 23 | Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses | International Immunology | 1998 | 425 |
| 24 | Human Fas ligand: gene structure, chromosomal location and species specificity | International Immunology | 1994 | 424 |
| 25 | PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells | International Immunology | 2004 | 413 |
| 26 | Roles of regulatory T cells in cancer immunity | International Immunology | 2016 | 412 |
| 27 | Macrophages in inflammation, repair and regeneration | International Immunology | 2018 | 402 |
| 28 | Hyperferritinemia and inflammation | International Immunology | 2017 | 385 |
| 29 | Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency | International Immunology | 1998 | 383 |
| 30 | Targeted disruption of the MHC class II Aa gene in C57BL/6 mice | International Immunology | 1993 | 375 |
| 31 | IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes | International Immunology | 1999 | 373 |
| 32 | High-level IL-12 production by human dendritic cells requires two signals | International Immunology | 1998 | 370 |
| 33 | Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus | International Immunology | 1993 | 369 |
| 34 | Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo | International Immunology | 1994 | 367 |
| 35 | NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma | International Immunology | 2001 | 365 |
| 36 | Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10 | International Immunology | 1990 | 357 |
| 37 | LacZ inducible, antigen/MHC-specific T cell hybrids | International Immunology | 1994 | 353 |
| 38 | IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IκB kinases | International Immunology | 1999 | 346 |
| 39 | CD4 + T-cell subsets in inflammatory diseases: beyond the T h 1/T h 2 paradigm | International Immunology | 2016 | 343 |
| 40 | Many of the IgA producing plasma cells in murine gut are derived from self-replenishing precursors in the peritoneal cavity | International Immunology | 1989 | 339 |
| 41 | Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by Th3/Tr1-type cytokines IL-10 and transforming growth factor-β but not by a Th1 to Th2 shift | International Immunology | 2000 | 334 |
| 42 | Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent | International Immunology | 1993 | 326 |
| 43 | Reversal of in vitro T cell clonal anergy by IL-2 stimulation | International Immunology | 1992 | 322 |
| 44 | Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis | International Immunology | 2006 | 320 |
| 45 | Differential ability of Th1 and Th2 T cells to express Fas ligand and to undergo activation-induced cell death | International Immunology | 1994 | 317 |
| 46 | IL-5- and eosinophil-mediated inflammation: from discovery to therapy | International Immunology | 2009 | 315 |
| 47 | CCR4 and its ligands: from bench to bedside | International Immunology | 2015 | 314 |
| 48 | Survival of long-lived plasma cells is independent of antigen [In Process Citation] | International Immunology | 1998 | 307 |
| 49 | IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells | International Immunology | 2004 | 305 |
| 50 | IL-12 synergizes with IL-18 or IL-1β for IFN-γ production from human T cells | International Immunology | 2000 | 302 |
