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Top Articles

#TitleJournalYearPR Citations
1AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1Nature Cell Biology20115,666
2Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communicationNature Cell Biology20192,924
3Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in miceNature Cell Biology20142,905
4The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expressionNature Cell Biology20002,843
5The AMPK signalling pathway coordinates cell growth, autophagy and metabolismNature Cell Biology20112,383
6TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signallingNature Cell Biology20022,357
7AP-1 as a regulator of cell life and deathNature Cell Biology20022,319
8PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1Nature Cell Biology20102,266
9Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translationNature Cell Biology20182,251
10Dynamic interaction of BiP and ER stress transducers in the unfolded-protein responseNature Cell Biology20002,212
11MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteinsNature Cell Biology20112,138
12Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stressNature Cell Biology20112,132
13The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cellsNature Cell Biology20002,109
14Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesisNature Cell Biology20002,102
15Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liverNature Cell Biology20152,083
16Rab27a and Rab27b control different steps of the exosome secretion pathwayNature Cell Biology20092,067
17Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivoNature Cell Biology20012,031
18The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1Nature Cell Biology20101,978
19Many roads to maturity: microRNA biogenesis pathways and their regulationNature Cell Biology20091,966
20Autophagosome formation: core machinery and adaptationsNature Cell Biology20071,647
21A complex secretory program orchestrated by the inflammasome controls paracrine senescenceNature Cell Biology20131,644
22α-Synuclein is phosphorylated in synucleinopathy lesionsNature Cell Biology20021,637
23Eaten alive: a history of macroautophagyNature Cell Biology20101,612
24Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substratesNature Cell Biology20011,557
25Causes and consequences of replication stressNature Cell Biology20131,473
26Wnt activity defines colon cancer stem cells and is regulated by the microenvironmentNature Cell Biology20101,418
27Syndecan–syntenin–ALIX regulates the biogenesis of exosomesNature Cell Biology20121,418
28During autophagy mitochondria elongate, are spared from degradation and sustain cell viabilityNature Cell Biology20111,352
29ER-stress-induced transcriptional regulation increases protein synthesis leading to cell deathNature Cell Biology20131,339
30Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transitionNature Cell Biology20041,323
31The multifaceted contributions of mitochondria to cellular metabolismNature Cell Biology20181,317
32p53 mutations in cancerNature Cell Biology20131,302
33Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionationNature Cell Biology20181,263
34Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathwaysNature Cell Biology20011,229
35Induction of autophagy by spermidine promotes longevityNature Cell Biology20091,226
36ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinaseNature Cell Biology20131,226
37Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesisNature Cell Biology20101,219
38SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27Nature Cell Biology19991,208
39Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosomeNature Cell Biology20001,194
40Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau proteinNature Cell Biology20001,187
41Autophagy in mammalian development and differentiationNature Cell Biology20101,174
42Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cellsNature Cell Biology20071,169
43Organelle-specific initiation of cell death pathwaysNature Cell Biology20011,165
44Isolation of multipotent adult stem cells from the dermis of mammalian skinNature Cell Biology20011,153
45Metabolic pathways promoting cancer cell survival and growthNature Cell Biology20151,142
46Mechanisms of mitophagy in cellular homeostasis, physiology and pathologyNature Cell Biology20181,141
47Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblastsNature Cell Biology20131,112
48Protein S-nitrosylation: a physiological signal for neuronal nitric oxideNature Cell Biology20011,104
49Lysosomal calcium signalling regulates autophagy through calcineurin and TFEBNature Cell Biology20151,088
50Direct regulation of TWIST by HIF-1α promotes metastasisNature Cell Biology20081,076