| # | Title | Journal | Year | Citations |
|---|
| 1 | 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data | Xenobiotica | 1999 | 3,429 |
| 2 | Mammalian Epoxide Hydrases: Inducible Enzymes Catalysing the Inactivation of Carcinogenic and Cytotoxic Metabolites Derived from Aromatic and Olefinic Compounds | Xenobiotica | 1973 | 818 |
| 3 | Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition | Xenobiotica | 2008 | 499 |
| 4 | Interaction of a series of nitriles with the alcohol-inducible isoform of P450: Computer analysis of structure—activity relationships | Xenobiotica | 1994 | 449 |
| 5 | Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid | Xenobiotica | 1992 | 434 |
| 6 | Role of transport proteins in drug absorption, distribution and excretion | Xenobiotica | 2001 | 424 |
| 7 | Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man | Xenobiotica | 1999 | 377 |
| 8 | Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family | Xenobiotica | 2008 | 371 |
| 9 | Accumulation of metformin by tissues of the normal and diabetic mouse | Xenobiotica | 1994 | 359 |
| 10 | Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells | Xenobiotica | 2002 | 340 |
| 11 | Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man | Xenobiotica | 2000 | 333 |
| 12 | Inhibition and induction of human cytochrome P450 (CYP) enzymes | Xenobiotica | 1998 | 325 |
| 13 | The Metabolism and Excretion of Curcumin (1,7-Bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) in the Rat | Xenobiotica | 1978 | 301 |
| 14 | Central role of radical cations in metabolic activation of polycyclic aromatic hydrocarbons | Xenobiotica | 1995 | 294 |
| 15 | Purification, characterization and regulation of five rat hepatic microsomal cytochrome P-450 isozymes | Xenobiotica | 1982 | 285 |
| 16 | Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9 | Xenobiotica | 1995 | 260 |
| 17 | Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: A resource for investigations into drug disposition | Xenobiotica | 2006 | 249 |
| 18 | Intestinal permeability and its relevance for absorption and elimination | Xenobiotica | 2007 | 245 |
| 19 | Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation ofin vitrometabolism using cDNA-expressed human P450s and human liver microsomes | Xenobiotica | 1996 | 244 |
| 20 | Interspecies scaling: predicting clearance of drugs in humans. Three different approaches | Xenobiotica | 1996 | 243 |
| 21 | Peptide transporters and their roles in physiological processes and drug disposition | Xenobiotica | 2008 | 233 |
| 22 | Cytochromes P-450 in rats: structures, functions, properties and relevant human forms | Xenobiotica | 1992 | 231 |
| 23 | Determination of metabolites of xenobiotics in the bile of fish from polluted waterways | Xenobiotica | 1984 | 229 |
| 24 | Drug Metabolism under Pathological and Abnormal Physiological States in Animals and Man | Xenobiotica | 1977 | 224 |
| 25 | Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes | Xenobiotica | 2009 | 221 |
| 26 | Pharmacokinetic interactions between herbal remedies and medicinal drugs | Xenobiotica | 2002 | 220 |
| 27 | The Metabolism of Ibuprofen | Xenobiotica | 1973 | 214 |
| 28 | Prediction ofin vivodrug clearance fromin vitrodata. I: Impact of inter-individual variability | Xenobiotica | 2006 | 209 |
| 29 | In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus | Xenobiotica | 2000 | 205 |
| 30 | Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors | Xenobiotica | 2004 | 201 |
| 31 | Folate, folic acid and 5-methyltetrahydrofolate are not the same thing | Xenobiotica | 2014 | 200 |
| 32 | Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man | Xenobiotica | 2002 | 198 |
| 33 | The metabolism of cypermethrin in man: differences in urinary metabolite profiles following oral and dermal administration | Xenobiotica | 1992 | 194 |
| 34 | Effect of diet on the urinary excretion of hippuric acid and other dietary-derived aromatics in rat. A complex interaction between diet, gut microflora and substrate specificity | Xenobiotica | 1998 | 190 |
| 35 | Cytochrome P450 forms in fish: Catalytic, immunological and sequence similarities | Xenobiotica | 1989 | 187 |
| 36 | The Metabolism of Tamoxifen (I.C.I. 46,474) Part I : In Laboratory Animals | Xenobiotica | 1973 | 185 |
| 37 | Disposition in male volunteers of a subanaesthetic intravenous dose of an oil in water emulsion of14C-propofol | Xenobiotica | 1988 | 183 |
| 38 | Human equilibrative nucleoside transporter (ENT) family of nucleoside and nucleobase transporter proteins | Xenobiotica | 2008 | 181 |
| 39 | Specific Carcinogenic and Teratogenic Effects of ‘Indirect’ Alkylating Methyl and Ethyl compounds, and their Dependency on Stages of Ontogenic Developments | Xenobiotica | 1973 | 180 |
| 40 | Interaction of Cimetidine with Liver Microsomes | Xenobiotica | 1979 | 179 |
| 41 | A regulatory viewpoint on transporter-based drug interactions | Xenobiotica | 2008 | 178 |
| 42 | In vitrobiotransformation of flavonoids by rat liver microsomes | Xenobiotica | 1998 | 171 |
| 43 | Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues | Xenobiotica | 2012 | 170 |
| 44 | Binding of14C-Carbon Tetrachloride to Microsomal Proteinsin vitroand Formation of CHCl3by Reduced Liver Microsomes | Xenobiotica | 1973 | 168 |
| 45 | Detoxication reactions of glutathione and glutathione transferases | Xenobiotica | 1986 | 168 |
| 46 | Evolution of the cytochrome P450 genes | Xenobiotica | 1989 | 167 |
| 47 | Influence of a series of natural flavonoids on free radical generating systems and oxidative stress | Xenobiotica | 1994 | 163 |
| 48 | Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, andin vitro–in vivocorrelations | Xenobiotica | 2007 | 163 |
| 49 | Mechanisms of Azo Reduction byStreptococcus faecalisII. The Role of Soluble Flavins | Xenobiotica | 1971 | 161 |
| 50 | Mutagenic properties of allylic and α,β-unsaturated compounds: Consideration of alkylating mechanisms | Xenobiotica | 1982 | 160 |
