| 1 | Computer Visualization of Three-Dimensional Image Data Using IMOD | Journal of Structural Biology | 1996 | 4,048 |
| 2 | RELION: Implementation of a Bayesian approach to cryo-EM structure determination | Journal of Structural Biology | 2012 | 4,030 |
| 3 | Automated electron microscope tomography using robust prediction of specimen movements | Journal of Structural Biology | 2005 | 3,769 |
| 4 | CTFFIND4: Fast and accurate defocus estimation from electron micrographs | Journal of Structural Biology | 2015 | 3,627 |
| 5 | Gctf: Real-time CTF determination and correction | Journal of Structural Biology | 2016 | 2,759 |
| 6 | EMAN2: An extensible image processing suite for electron microscopy | Journal of Structural Biology | 2007 | 2,317 |
| 7 | XtalView/Xfit—A Versatile Program for Manipulating Atomic Coordinates and Electron Density | Journal of Structural Biology | 1999 | 1,992 |
| 8 | EMAN: Semiautomated Software for High-Resolution Single-Particle Reconstructions | Journal of Structural Biology | 1999 | 1,967 |
| 9 | SPIDER and WEB: Processing and Visualization of Images in 3D Electron Microscopy and Related Fields | Journal of Structural Biology | 1996 | 1,695 |
| 10 | Automated molecular microscopy: The new Leginon system | Journal of Structural Biology | 2005 | 1,289 |
| 11 | Accurate determination of local defocus and specimen tilt in electron microscopy | Journal of Structural Biology | 2003 | 1,194 |
| 12 | A New Generation of the IMAGIC Image Processing System | Journal of Structural Biology | 1996 | 1,008 |
| 13 | Feature point tracking and trajectory analysis for video imaging in cell biology | Journal of Structural Biology | 2005 | 998 |
| 14 | Dual-Axis Tomography: An Approach with Alignment Methods That Preserve Resolution | Journal of Structural Biology | 1997 | 773 |
| 15 | Review: History of the Amyloid Fibril | Journal of Structural Biology | 2000 | 762 |
| 16 | Mechanism of thioflavin T binding to amyloid fibrils | Journal of Structural Biology | 2005 | 687 |
| 17 | Visualizing density maps with UCSF Chimera | Journal of Structural Biology | 2007 | 684 |
| 18 | Fourier shell correlation threshold criteria | Journal of Structural Biology | 2005 | 659 |
| 19 | Mineralization in Ferritin: An Efficient Means of Iron Storage | Journal of Structural Biology | 1999 | 654 |
| 20 | Appion: An integrated, database-driven pipeline to facilitate EM image processing | Journal of Structural Biology | 2009 | 650 |
| 21 | 3D variability analysis: Resolving continuous flexibility and discrete heterogeneity from single particle cryo-EM | Journal of Structural Biology | 2021 | 618 |
| 22 | MRC Image Processing Programs | Journal of Structural Biology | 1996 | 612 |
| 23 | The binding of thioflavin-T to amyloid fibrils: localisation and implications | Journal of Structural Biology | 2005 | 612 |
| 24 | Evolutionary history and higher order classification of AAA+ ATPases | Journal of Structural Biology | 2004 | 594 |
| 25 | Review: Alzheimer's Amyloid β-Peptide-Associated Free Radical Oxidative Stress and Neurotoxicity | Journal of Structural Biology | 2000 | 590 |
| 26 | A structural analysis of M protein in coronavirus assembly and morphology | Journal of Structural Biology | 2011 | 539 |
| 27 | Nuclear Lamins: Their Structure, Assembly, and Interactions | Journal of Structural Biology | 1998 | 523 |
| 28 | UCSF Chimera, MODELLER, and IMP: An integrated modeling system | Journal of Structural Biology | 2012 | 500 |
| 29 | Cyanobacterial Phycobilisomes | Journal of Structural Biology | 1998 | 494 |
| 30 | Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with β-amyloid deposits in Alzheimer’s disease | Journal of Structural Biology | 2006 | 486 |
| 31 | Automated tilt series alignment and tomographic reconstruction in IMOD | Journal of Structural Biology | 2017 | 486 |
| 32 | Fibrillar Structure and Mechanical Properties of Collagen | Journal of Structural Biology | 1998 | 484 |
| 33 | Implementation of a cryo-electron tomography tilt-scheme optimized for high resolution subtomogram averaging | Journal of Structural Biology | 2017 | 481 |
| 34 | Protein Repeats: Structures, Functions, and Evolution | Journal of Structural Biology | 2001 | 478 |
| 35 | Lamellar Bone: Structure–Function Relations | Journal of Structural Biology | 1999 | 471 |
| 36 | The Structural Biology of the Developing Dental Enamel Matrix | Journal of Structural Biology | 1999 | 455 |
| 37 | Mineral and Organic Matrix Interaction in Normally Calcifying Tendon Visualized in Three Dimensions by High-Voltage Electron Microscopic Tomography and Graphic Image Reconstruction | Journal of Structural Biology | 1993 | 449 |
| 38 | DoG Picker and TiltPicker: Software tools to facilitate particle selection in single particle electron microscopy | Journal of Structural Biology | 2009 | 440 |
| 39 | Situs: A Package for Docking Crystal Structures into Low-Resolution Maps from Electron Microscopy | Journal of Structural Biology | 1999 | 420 |
| 40 | Scipion: A software framework toward integration, reproducibility and validation in 3D electron microscopy | Journal of Structural Biology | 2016 | 414 |
| 41 | Structural characterization of proteins and complexes using small-angle X-ray solution scattering | Journal of Structural Biology | 2010 | 409 |
| 42 | Structure of the Nacreous Organic Matrix of a Bivalve Mollusk Shell Examined in the Hydrated State Using Cryo-TEM | Journal of Structural Biology | 2001 | 405 |
| 43 | Bsoft: Image processing and molecular modeling for electron microscopy | Journal of Structural Biology | 2007 | 393 |
| 44 | Building Collagen Molecules, Fibrils, and Suprafibrillar Structures | Journal of Structural Biology | 2002 | 378 |
| 45 | Helical reconstruction in RELION | Journal of Structural Biology | 2017 | 377 |
| 46 | FREALIGN: High-resolution refinement of single particle structures | Journal of Structural Biology | 2007 | 357 |
| 47 | XMIPP: a new generation of an open-source image processing package for electron microscopy | Journal of Structural Biology | 2004 | 355 |
| 48 | Transient amorphous calcium phosphate in forming enamel | Journal of Structural Biology | 2009 | 339 |
| 49 | Fold Change in Evolution of Protein Structures | Journal of Structural Biology | 2001 | 336 |
| 50 | Gly-X-Y Tripeptide Frequencies in Collagen: A Context for Host–Guest Triple-Helical Peptides | Journal of Structural Biology | 1998 | 320 |