| # | Title | Journal | Year | Citations |
|---|
| 1 | Oncology Meets Immunology: The Cancer-Immunity Cycle | Immunity | 2013 | 4,815 |
| 2 | Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines | Immunity | 2014 | 4,638 |
| 3 | The Immune Landscape of Cancer | Immunity | 2018 | 3,706 |
| 4 | Chemokines | Immunity | 2000 | 3,582 |
| 5 | Alternative Activation of Macrophages: Mechanism and Functions | Immunity | 2010 | 3,322 |
| 6 | TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells | Immunity | 2006 | 3,302 |
| 7 | IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines | Immunity | 2005 | 3,161 |
| 8 | Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity | Immunity | 2011 | 3,060 |
| 9 | Tumor-Associated Macrophages: From Mechanisms to Therapy | Immunity | 2014 | 3,060 |
| 10 | Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components | Immunity | 1999 | 3,040 |
| 11 | Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer | Immunity | 2013 | 2,983 |
| 12 | Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties | Immunity | 2003 | 2,947 |
| 13 | Identification and characterization of a new member of the TNF family that induces apoptosis | Immunity | 1995 | 2,724 |
| 14 | Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4 | Immunity | 1995 | 2,628 |
| 15 | Macrophages in Tissue Repair, Regeneration, and Fibrosis | Immunity | 2016 | 2,591 |
| 16 | Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis | Immunity | 2013 | 2,528 |
| 17 | The Immunobiology of Cancer Immunosurveillance and Immunoediting | Immunity | 2004 | 2,486 |
| 18 | Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12 | Immunity | 2000 | 2,463 |
| 19 | Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor | Immunity | 1999 | 2,336 |
| 20 | Interleukin-17 Family Members and Inflammation | Immunity | 2004 | 2,128 |
| 21 | Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3 | Immunity | 2005 | 2,070 |
| 22 | Maintenance of the Hematopoietic Stem Cell Pool by CXCL12-CXCR4 Chemokine Signaling in Bone Marrow Stromal Cell Niches | Immunity | 2006 | 2,010 |
| 23 | Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor | Immunity | 2009 | 1,955 |
| 24 | CTLA-4 can function as a negative regulator of T cell activation | Immunity | 1994 | 1,949 |
| 25 | Inflammation and Cancer: Triggers, Mechanisms, and Consequences | Immunity | 2019 | 1,946 |
| 26 | Unresponsiveness of MyD88-Deficient Mice to Endotoxin | Immunity | 1999 | 1,906 |
| 27 | Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function | Immunity | 1998 | 1,890 |
| 28 | Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection | Immunity | 1998 | 1,887 |
| 29 | B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes | Immunity | 2000 | 1,884 |
| 30 | Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes | Immunity | 2013 | 1,767 |
| 31 | The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases | Immunity | 2017 | 1,741 |
| 32 | The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation | Immunity | 2008 | 1,721 |
| 33 | The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation | Immunity | 2011 | 1,698 |
| 34 | Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection | Immunity | 2007 | 1,695 |
| 35 | Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation | Immunity | 2014 | 1,692 |
| 36 | Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22 | Immunity | 2013 | 1,663 |
| 37 | Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis | Immunity | 2014 | 1,654 |
| 38 | Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA | Immunity | 2005 | 1,650 |
| 39 | Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis | Immunity | 2012 | 1,618 |
| 40 | K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter | Immunity | 2013 | 1,602 |
| 41 | In Vivo Depletion of CD11c+ Dendritic Cells Abrogates Priming of CD8+ T Cells by Exogenous Cell-Associated Antigens | Immunity | 2002 | 1,579 |
| 42 | Immune Signaling by RIG-I-like Receptors | Immunity | 2011 | 1,570 |
| 43 | NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder | Immunity | 2004 | 1,566 |
| 44 | The Interleukin-1 Family: Back to the Future | Immunity | 2013 | 1,560 |
| 45 | Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice | Immunity | 1995 | 1,545 |
| 46 | Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor | Immunity | 2007 | 1,542 |
| 47 | Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation | Immunity | 2016 | 1,538 |
| 48 | Vaccine Adjuvants: Putting Innate Immunity to Work | Immunity | 2010 | 1,522 |
| 49 | Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells | Immunity | 1999 | 1,512 |
| 50 | Reactive Astrocytes: Production, Function, and Therapeutic Potential | Immunity | 2017 | 1,507 |
