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Top Articles

#TitleJournalYearCitations
1Oncology Meets Immunology: The Cancer-Immunity CycleImmunity20134,935
2The Immune Landscape of CancerImmunity20183,850
3Macrophages in Tissue Repair, Regeneration, and FibrosisImmunity20163,215
4Alternative Activation of Macrophages: Mechanism and FunctionsImmunity20103,099
5Tumor-Associated Macrophages: From Mechanisms to TherapyImmunity20143,040
6Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human CancerImmunity20132,920
7ChemokinesImmunity20002,794
8IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated CytokinesImmunity20052,727
9Inflammation and Cancer: Triggers, Mechanisms, and ConsequencesImmunity20192,725
10Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and ImmunityImmunity20112,632
11TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T CellsImmunity20062,540
12Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory PropertiesImmunity20032,371
13Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall ComponentsImmunity19992,357
14Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under HomeostasisImmunity20132,285
15Identification and characterization of a new member of the TNF family that induces apoptosisImmunity19952,092
16Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12Immunity20001,938
17The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative DiseasesImmunity20171,933
18Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4Immunity19951,932
19The Immunobiology of Cancer Immunosurveillance and ImmunoeditingImmunity20041,916
20Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying ImmunoreceptorImmunity19991,872
21Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22Immunity20131,839
22Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNAImmunity20051,800
23Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and CarcinogenesisImmunity20141,774
24Transforming Growth Factor-β Signaling in Immunity and CancerImmunity20191,743
25Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during ApoptosisImmunity20121,727
26Reactive Astrocytes: Production, Function, and Therapeutic PotentialImmunity20171,708
27Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription FactorImmunity20091,685
28Maintenance of the Hematopoietic Stem Cell Pool by CXCL12-CXCR4 Chemokine Signaling in Bone Marrow Stromal Cell NichesImmunity20061,668
29Regulation and Function of the PD-L1 CheckpointImmunity20181,648
30Interleukin-17 Family Members and InflammationImmunity20041,641
31K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate MatterImmunity20131,630
32Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating MonocytesImmunity20131,621
33Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune RegulationImmunity20161,584
34STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic TumorsImmunity20141,569
35Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3Immunity20051,564
36The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte ActivationImmunity20111,564
37Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage ActivationImmunity20141,547
38Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral InfectionImmunity20071,529
39Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage PolarizationImmunity20151,504
40CTLA-4 can function as a negative regulator of T cell activationImmunity19941,476
41Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State ChangesImmunity20191,446
42The Interleukin-1 Family: Back to the FutureImmunity20131,440
43STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic TumorsImmunity20141,420
44Unresponsiveness of MyD88-Deficient Mice to EndotoxinImmunity19991,410
45Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated FunctionImmunity19981,402
46Inflammation in obesity, diabetes, and related disordersImmunity20221,390
47The Biological Functions of T Helper 17 Cell Effector Cytokines in InflammationImmunity20081,381
48Immune Signaling by RIG-I-like ReceptorsImmunity20111,372
49Vaccine Adjuvants: Putting Innate Immunity to WorkImmunity20101,369
50NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory DisorderImmunity20041,343