| # | Title | Journal | Year | Citations |
|---|
| 1 | The role of p53 in apoptosis | Discovery Medicine | 2010 | 216 |
| 2 | Interferon-γ and systemic autoimmunity | Discovery Medicine | 2013 | 173 |
| 3 | The nuclear epidermal growth factor receptor signaling network and its role in cancer | Discovery Medicine | 2011 | 150 |
| 4 | Noroviruses: The leading cause of gastroenteritis worldwide | Discovery Medicine | 2010 | 141 |
| 5 | Advances and challenges in the treatment of glioblastoma: a clinician's perspective | Discovery Medicine | 2013 | 140 |
| 6 | A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya) | Discovery Medicine | 2011 | 139 |
| 7 | Does emotional stress cause type 2 diabetes mellitus? A review from the European Depression in Diabetes (EDID) Research Consortium | Discovery Medicine | 2010 | 136 |
| 8 | Advances in targeted therapy for osteosarcoma | Discovery Medicine | 2014 | 130 |
| 9 | Adipose-derived stem cells: current findings and future perspectives | Discovery Medicine | 2011 | 126 |
| 10 | Adipose tissue inflammation in obesity and metabolic syndrome | Discovery Medicine | 2009 | 124 |
| 11 | Vitamin D, vitamin D receptor, and macroautophagy in inflammation and infection | Discovery Medicine | 2011 | 123 |
| 12 | Mitochondria-targeted antioxidants as therapies | Discovery Medicine | 2011 | 113 |
| 13 | A prospective, randomized, double-blind study assessing the clinical impact of integrated pharmacogenomic testing for major depressive disorder | Discovery Medicine | 2013 | 112 |
| 14 | Rationale for targeting the Ras/MAPK pathway in triple-negative breast cancer | Discovery Medicine | 2014 | 112 |
| 15 | Aging, immunity, and cancer | Discovery Medicine | 2011 | 111 |
| 16 | Cervical cancer: prevention and treatment | Discovery Medicine | 2012 | 106 |
| 17 | Advances in the understanding of mechanisms and therapeutic use of bortezomib | Discovery Medicine | 2011 | 105 |
| 18 | Therapeutic photobiomodulation: nitric oxide and a novel function of mitochondrial cytochrome c oxidase | Discovery Medicine | 2011 | 104 |
| 19 | The functional neuroanatomy of pleasure and happiness | Discovery Medicine | 2010 | 103 |
| 20 | Gram-negative outer membrane vesicles in vaccine development | Discovery Medicine | 2011 | 96 |
| 21 | Recent advances in non-small cell lung cancer biology and clinical management | Discovery Medicine | 2012 | 95 |
| 22 | Targeting isocitrate dehydrogenase (IDH) in cancer | Discovery Medicine | 2016 | 92 |
| 23 | Prostate specific membrane antigen- a target for imaging and therapy with radionuclides | Discovery Medicine | 2010 | 91 |
| 24 | Rotavirus diversity and evolution in the post-vaccine world | Discovery Medicine | 2012 | 89 |
| 25 | Inflammation in aging: cause, effect, or both? | Discovery Medicine | 2012 | 89 |
| 26 | Collagen 1A1 (COL1A1) promotes metastasis of breast cancer and is a potential therapeutic target | Discovery Medicine | 2018 | 89 |
| 27 | GM-CSF-secreting vaccines for solid tumors: moving forward | Discovery Medicine | 2010 | 85 |
| 28 | mTOR signaling: a central pathway to pathogenesis in systemic lupus erythematosus? | Discovery Medicine | 2010 | 85 |
| 29 | Wnt signaling in dendritic cells: its role in regulation of immunity and tolerance | Discovery Medicine | 2015 | 85 |
| 30 | The cost of new drug discovery and development | Discovery Medicine | 2004 | 85 |
| 31 | Environmental triggers and epigenetic deregulation in autoimmune disease | Discovery Medicine | 2011 | 85 |
| 32 | Viral expression cassette elements to enhance transgene target specificity and expression in gene therapy | Discovery Medicine | 2015 | 84 |
| 33 | Current concepts in diagnosing and managing primary vitreoretinal (intraocular) lymphoma | Discovery Medicine | 2013 | 80 |
| 34 | Gaucher disease: insights from a rare Mendelian disorder | Discovery Medicine | 2012 | 80 |
| 35 | Hedgehog pathway and GLI1 isoforms in human cancer | Discovery Medicine | 2012 | 79 |
| 36 | The next generation of antibody-drug conjugates comes of age | Discovery Medicine | 2010 | 78 |
| 37 | Biomarkers for chronic pain and analgesia. Part 1: the need, reality, challenges, and solutions | Discovery Medicine | 2011 | 78 |
| 38 | Network medicine approaches to the genetics of complex diseases | Discovery Medicine | 2012 | 75 |
| 39 | The immunogenicity of therapeutic proteins | Discovery Medicine | 2010 | 75 |
| 40 | Inflammasome activation in obesity-related inflammatory diseases and autoimmunity | Discovery Medicine | 2011 | 74 |
| 41 | EGFR and downstream genetic alterations in KRAS/BRAF and PI3K/AKT pathways in colorectal cancer: implications for targeted therapy | Discovery Medicine | 2012 | 73 |
| 42 | Persisting long term benefits of smoking abstinence and reduction in asthmatic smokers who have switched to electronic cigarettes | Discovery Medicine | 2016 | 73 |
| 43 | Molecular diagnostics and targeted therapies in non-small cell lung cancer (NSCLC): an update | Discovery Medicine | 2019 | 73 |
| 44 | Role of platelet-derived microparticles in angiogenesis and tumor progression | Discovery Medicine | 2009 | 72 |
| 45 | Histone deacetylase inhibitors in the treatment of lymphoma | Discovery Medicine | 2010 | 72 |
| 46 | Aerobic exercise in the elderly: a key to successful aging | Discovery Medicine | 2012 | 72 |
| 47 | Role of the IL-23/IL-17 axis in Crohn's disease | Discovery Medicine | 2012 | 71 |
| 48 | Stroke induces a rapid adaptive autoimmune response to novel neuronal antigens | Discovery Medicine | 2015 | 69 |
| 49 | Asthma phenotypes and endotypes: an evolving paradigm for classification | Discovery Medicine | 2013 | 69 |
| 50 | The impact of antibiotics on the gut microbiota as revealed by high throughput DNA sequencing | Discovery Medicine | 2012 | 68 |
