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Top Articles

1DNA methylation patterns and epigenetic memoryGenes and Development20025,932
2CDK inhibitors: positive and negative regulators of G1-phase progressionGenes and Development19995,227
3Cellular survival: a play in three AktsGenes and Development19993,729
4Upstream and downstream of mTORGenes and Development20043,638
5Signaling to NF-κBGenes and Development20043,444
6Autophagy: process and functionGenes and Development20073,312
7BCL-2 family members and the mitochondria in apoptosisGenes and Development19993,224
8Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclassesGenes and Development20113,208
9Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domainGenes and Development19993,000
10Inhibitors of mammalian G1 cyclin-dependent kinases.Genes and Development19952,940
11RNA interference is mediated by 21- and 22-nucleotide RNAsGenes and Development20012,761
12Hedgehog signaling in animal development: paradigms and principlesGenes and Development20012,630
13Wnt signaling and cancerGenes and Development20002,589
14CpG islands and the regulation of transcriptionGenes and Development20112,555
15Shelterin: the protein complex that shapes and safeguards human telomeresGenes and Development20052,547
16Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth controlGenes and Development20072,487
17Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAsGenes and Development20032,377
18Wnt signaling and cancerGenes and Development20002,322
19Wnt signaling: a common theme in animal developmentGenes and Development19972,276
20IAP family proteins---suppressors of apoptosisGenes and Development19992,250
21osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcificationGenes and Development19982,176
22p53: puzzle and paradigm.Genes and Development19962,145
23Rho GTPases and signaling networksGenes and Development19972,140
24Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1αGenes and Development19982,139
25In vitro propagation and transcriptional profiling of human mammary stem/progenitor cellsGenes and Development20032,114
26The regulation of E2F by pRB-family proteinsGenes and Development19982,069
27Smad transcription factorsGenes and Development20052,063
28Long noncoding RNAs: functional surprises from the RNA worldGenes and Development20092,032
29Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controlsGenes and Development19992,016
30The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2Genes and Development20082,007
31Multipotent cell lineages in early mouse development depend on SOX2 functionGenes and Development20032,000
32mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.Genes and Development19941,994
33Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleusGenes and Development20001,955
34Molecular imaging in living subjects: seeing fundamental biological processes in a new lightGenes and Development20031,954
35Malignant astrocytic glioma: genetics, biology, and paths to treatmentGenes and Development20071,952
36The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanismsGenes and Development19991,951
37TEAD mediates YAP-dependent gene induction and growth controlGenes and Development20081,943
38Role of platelet-derived growth factors in physiology and medicineGenes and Development20081,904
39Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localizationGenes and Development19981,883
40The expanding role of mitochondria in apoptosisGenes and Development20011,827
41Control of translation and mRNA degradation by miRNAs and siRNAs: Table 1.Genes and Development20061,814
42The coregulator exchange in transcriptional functions of nuclear receptorsGenes and Development20001,810
43MicroRNAs in plantsGenes and Development20021,797
44Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.Genes and Development19931,776
45The Drosha-DGCR8 complex in primary microRNA processingGenes and Development20041,774
46CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumGenes and Development19981,767
47Bone morphogenetic proteins: multifunctional regulators of vertebrate development.Genes and Development19961,766
48p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.Genes and Development19941,731
49The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.Genes and Development19941,728
50Cell cycle checkpoint signaling through the ATM and ATR kinasesGenes and Development20011,716