| # | Title | Journal | Year | Citations |
|---|
| 1 | HMGB1 SIGNALS THROUGH TOLL-LIKE RECEPTOR (TLR) 4 AND TLR2 | Shock | 2006 | 730 |
| 2 | A Unified Theory of Sepsis-Induced Acute Kidney Injury | Shock | 2014 | 602 |
| 3 | CECAL LIGATION AND PUNCTURE | Shock | 2005 | 588 |
| 4 | HEAT SHOCK PROTEINS: FACTS, THOUGHTS, AND DREAMS | Shock | 1999 | 529 |
| 5 | ANIMAL MODELS OF SEPSIS AND SHOCK | Shock | 1998 | 510 |
| 6 | EFFECT OF GENDER AND SEX HORMONES ON IMMUNE RESPONSES FOLLOWING SHOCK | Shock | 2000 | 474 |
| 7 | The Endothelium in Sepsis | Shock | 2016 | 453 |
| 8 | COMPARISON OF THE MORTALITY AND INFLAMMATORY RESPONSE OF TWO MODELS OF SEPSIS: LIPOPOLYSACCHARIDE VS. CECAL LIGATION AND PUNCTURE | Shock | 2000 | 448 |
| 9 | POST-INJURY MULTIPLE ORGAN FAILURE: THE ROLE OF THE GUT | Shock | 2001 | 447 |
| 10 | THE CELLULAR, METABOLIC, AND SYSTEMIC CONSEQUENCES OF AGGRESSIVE FLUID RESUSCITATION STRATEGIES | Shock | 2006 | 444 |
| 11 | THE PATHOPHYSIOLOGICAL ROLE OF PEROXYNITRITE IN SHOCK, INFLAMMATION, AND ISCHEMIA-REPERFUSION INJURY | Shock | 1996 | 441 |
| 12 | MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response | Shock | 2016 | 424 |
| 13 | SEPSIS SYNDROMES: UNDERSTANDING THE ROLE OF INNATE AND ACQUIRED IMMUNITY | Shock | 2001 | 422 |
| 14 | SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS), MULTIPLE ORGAN DYSFUNCTION SYNDROME (MODS), MULTIPLE ORGAN FAILURE (MOF) | Shock | 1998 | 410 |
| 15 | INNATE IMMUNE RESPONSE IN TH1- AND TH2-DOMINANT MOUSE STRAINS | Shock | 2004 | 409 |
| 16 | Six at Six: Interleukin-6 Measured 6 H After the Initiation of Sepsis Predicts Mortality Over 3 Days | Shock | 2002 | 400 |
| 17 | INTESTINAL CROSSTALK | Shock | 2007 | 385 |
| 18 | Persistent Lymphopenia After Diagnosis of Sepsis Predicts Mortality | Shock | 2014 | 324 |
| 19 | MULTICENTER STUDY OF EARLY LACTATE CLEARANCE AS A DETERMINANT OF SURVIVAL IN PATIENTS WITH PRESUMED SEPSIS | Shock | 2009 | 322 |
| 20 | Early Circulating Lymphocyte Apoptosis in Human Septic Shock Is Associated with Poor Outcome | Shock | 2002 | 309 |
| 21 | MITOCHONDRIAL DNA IS RELEASED BY SHOCK AND ACTIVATES NEUTROPHILS VIA P38 MAP KINASE | Shock | 2010 | 290 |
| 22 | Fluid Overload in Patients With Severe Sepsis and Septic Shock Treated With Early Goal-Directed Therapy Is Associated With Increased Acute Need for Fluid-Related Medical Interventions and Hospital Death | Shock | 2015 | 289 |
| 23 | EMERGING PARADIGM | Shock | 2006 | 282 |
| 24 | THE ROLE OF THE COMPLEMENT SYSTEM IN ISCHEMIA-REPERFUSION INJURY | Shock | 2004 | 281 |
| 25 | ROLE OF CEREBRAL INFLAMMATION AFTER TRAUMATIC BRAIN INJURY: A REVISITED CONCEPT | Shock | 2001 | 275 |
| 26 | THE EFFECTS OF INJURY ON THE ADAPTIVE IMMUNE RESPONSE | Shock | 1999 | 271 |
| 27 | EVIDENCE FAVORING THE ROLE OF THE GUT AS A CYTOKINE-GENERATING ORGAN IN RATS SUBJECTED TO HEMORRHAGIC SHOCK | Shock | 1994 | 265 |
| 28 | A PILOT-CONTROLLED STUDY OF A POLYMYXIN B-IMMOBILIZED HEMOPERFUSION CARTRIDGE IN PATIENTS WITH SEVERE SEPSIS SECONDARY TO INTRA-ABDOMINAL INFECTION | Shock | 2005 | 264 |
| 29 | TOLL-LIKE RECEPTORS IN ISCHEMIA-REPERFUSION INJURY | Shock | 2009 | 264 |
| 30 | Pulmonary Angiotensin-Converting Enzyme 2 (ACE2) and Inflammatory Lung Disease | Shock | 2016 | 259 |
| 31 | CYTOKINE EXPRESSION PROFILE OVER TIME IN SEVERELY BURNED PEDIATRIC PATIENTS | Shock | 2006 | 246 |
| 32 | INTRATHECAL AND SERUM INTERLEUKIN-6 AND THE ACUTE-PHASE RESPONSE IN PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURIES | Shock | 1995 | 245 |
| 33 | ROLE OF TOLL-LIKE RECEPTORS 2 AND 4, AND THE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS IN HIGH-MOBILITY GROUP BOX 1-INDUCED INFLAMMATION IN VIVO | Shock | 2009 | 237 |
| 34 | NF-??B Activation and Inhibition: A Review | Shock | 2002 | 235 |
| 35 | COPEPTIN, A STABLE PEPTIDE OF THE ARGININE VASOPRESSIN PRECURSOR, IS ELEVATED IN HEMORRHAGIC AND SEPTIC SHOCK | Shock | 2007 | 234 |
| 36 | ELEVATED HIGH-MOBILITY GROUP BOX 1 LEVELS IN PATIENTS WITH CEREBRAL AND MYOCARDIAL ISCHEMIA | Shock | 2006 | 226 |
| 37 | LIVER ISCHEMIA AND REPERFUSION INDUCES A SYSTEMIC INFLAMMATORY RESPONSE THROUGH KUPFFER CELL ACTIVATION | Shock | 1996 | 225 |
| 38 | INCREASED LEVELS OF GLYCOSAMINOGLYCANS DURING SEPTIC SHOCK | Shock | 2008 | 224 |
| 39 | ANTI-APOPTOTIC AND ANTI-INFLAMMATORY EFFECTS OF HYDROGEN SULFIDE IN A RAT MODEL OF REGIONAL MYOCARDIAL I/R | Shock | 2009 | 224 |
| 40 | THE ROLE OF CXC CHEMOKINES AS REGULATORS OF ANGIOGENESIS | Shock | 1995 | 221 |
| 41 | SUSPENDED ANIMATION-LIKE STATE PROTECTS MICE FROM LETHAL HYPOXIA | Shock | 2007 | 219 |
| 42 | ACUTE PANCREATITIS: MODELS, MARKERS, AND MEDIATORS | Shock | 2005 | 216 |
| 43 | FLUID RESUSCITATION | Shock | 2010 | 215 |
| 44 | CHANGES IN CSF S100B AND CYTOKINE CONCENTRATIONS IN EARLY-PHASE SEVERE TRAUMATIC BRAIN INJURY | Shock | 2004 | 211 |
| 45 | NEUTROPHIL-DERIVED CIRCULATING FREE DNA (cf-DNA/NETs) | Shock | 2008 | 209 |
| 46 | Hemostatic Function of Apheresis Platelets Stored at 4°C and 22°C | Shock | 2014 | 208 |
| 47 | Implantable Device-Related Infection | Shock | 2016 | 207 |
| 48 | EXPERIMENTAL MODELS OF SEPSIS AND THEIR CLINICAL RELEVANCE | Shock | 2008 | 205 |
| 49 | ROLE OF TOLL-LIKE RECEPTORS IN THE DEVELOPMENT OF SEPSIS | Shock | 2008 | 204 |
| 50 | CECAL LIGATION AND PUNCTURE VERSUS COLON ASCENDENS STENT PERITONITIS: TWO DISTINCT ANIMAL MODELS FOR POLYMICROBIAL SEPSIS | Shock | 2004 | 199 |
