# | Title | Journal | Year | Citations |
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|
1 | Full-length transcriptome assembly from RNA-Seq data without a reference genome | Nature Biotechnology | 2011 | 18,090 |
2 | Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation | Nature Biotechnology | 2010 | 14,198 |
3 | MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification | Nature Biotechnology | 2008 | 13,477 |
4 | Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 | Nature Biotechnology | 2019 | 12,956 |
5 | Integrative genomics viewer | Nature Biotechnology | 2011 | 12,409 |
6 | Integrating single-cell transcriptomic data across different conditions, technologies, and species | Nature Biotechnology | 2018 | 9,679 |
7 | StringTie enables improved reconstruction of a transcriptome from RNA-seq reads | Nature Biotechnology | 2015 | 9,345 |
8 | Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences | Nature Biotechnology | 2013 | 8,414 |
9 | Near-optimal probabilistic RNA-seq quantification | Nature Biotechnology | 2016 | 7,902 |
10 | Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype | Nature Biotechnology | 2019 | 7,823 |
11 | 3D bioprinting of tissues and organs | Nature Biotechnology | 2014 | 5,401 |
12 | Principles of nanoparticle design for overcoming biological barriers to drug delivery | Nature Biotechnology | 2015 | 5,199 |
13 | The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells | Nature Biotechnology | 2014 | 5,076 |
14 | Spatial reconstruction of single-cell gene expression data | Nature Biotechnology | 2015 | 4,733 |
15 | Quantitative analysis of complex protein mixtures using isotope-coded affinity tags | Nature Biotechnology | 1999 | 4,687 |
16 | Large-scale analysis of the yeast proteome by multidimensional protein identification technology | Nature Biotechnology | 2001 | 4,566 |
17 | In vivo cancer targeting and imaging with semiconductor quantum dots | Nature Biotechnology | 2004 | 4,504 |
18 | Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein | Nature Biotechnology | 2004 | 4,214 |
19 | Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering | Nature Biotechnology | 2005 | 4,130 |
20 | Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples | Nature Biotechnology | 2013 | 4,096 |
21 | DNA targeting specificity of RNA-guided Cas9 nucleases | Nature Biotechnology | 2013 | 4,085 |
22 | Molecular Beacons: Probes that Fluoresce upon Hybridization | Nature Biotechnology | 1996 | 3,987 |
23 | GREAT improves functional interpretation of cis-regulatory regions | Nature Biotechnology | 2010 | 3,977 |
24 | Renal clearance of quantum dots | Nature Biotechnology | 2007 | 3,893 |
25 | Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes | Nature Biotechnology | 2011 | 3,784 |
26 | Next-generation DNA sequencing | Nature Biotechnology | 2008 | 3,675 |
27 | Dimensionality reduction for visualizing single-cell data using UMAP | Nature Biotechnology | 2019 | 3,600 |
28 | Nonlinear magic: multiphoton microscopy in the biosciences | Nature Biotechnology | 2003 | 3,583 |
29 | Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies | Nature Biotechnology | 2006 | 3,578 |
30 | SignalP 5.0 improves signal peptide predictions using deep neural networks | Nature Biotechnology | 2019 | 3,566 |
31 | A clearer vision for in vivo imaging | Nature Biotechnology | 2001 | 3,459 |
32 | Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 | Nature Biotechnology | 2016 | 3,430 |
33 | What is flux balance analysis? | Nature Biotechnology | 2010 | 3,369 |
34 | Differential analysis of gene regulation at transcript resolution with RNA-seq | Nature Biotechnology | 2013 | 3,337 |
35 | Assembly of long, error-prone reads using repeat graphs | Nature Biotechnology | 2019 | 3,190 |
36 | Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling | Nature Biotechnology | 2009 | 3,144 |
37 | An economic method for the fluorescent labeling of PCR fragments | Nature Biotechnology | 2000 | 3,137 |
38 | PICRUSt2 for prediction of metagenome functions | Nature Biotechnology | 2020 | 3,120 |
39 | Fabrication of novel biomaterials through molecular self-assembly | Nature Biotechnology | 2003 | 3,081 |
40 | Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking | Nature Biotechnology | 2016 | 3,065 |
41 | Expression monitoring by hybridization to high-density oligonucleotide arrays | Nature Biotechnology | 1996 | 3,057 |
42 | A cross-platform toolkit for mass spectrometry and proteomics | Nature Biotechnology | 2012 | 3,018 |
43 | What is a support vector machine? | Nature Biotechnology | 2006 | 2,963 |
44 | The use of nanocrystals in biological detection | Nature Biotechnology | 2004 | 2,869 |
45 | High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells | Nature Biotechnology | 2013 | 2,843 |
46 | A standardized bacterial taxonomy based on genome phylogeny substantially revises the tree of life | Nature Biotechnology | 2018 | 2,798 |
47 | CRISPR-Cas systems for editing, regulating and targeting genomes | Nature Biotechnology | 2014 | 2,726 |
48 | Efficient genome editing in zebrafish using a CRISPR-Cas system | Nature Biotechnology | 2013 | 2,712 |
49 | Determining cell type abundance and expression from bulk tissues with digital cytometry | Nature Biotechnology | 2019 | 2,701 |
50 | Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts | Nature Biotechnology | 2008 | 2,614 |