| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. | EMBO Journal | 1996 | 48,188 |
| 2 | GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. | EMBO Journal | 1987 | 8,856 |
| 3 | LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing | EMBO Journal | 2000 | 5,949 |
| 4 | Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. | EMBO Journal | 1982 | 4,840 |
| 5 | MicroRNA genes are transcribed by RNA polymerase II | EMBO Journal | 2004 | 3,776 |
| 6 | Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. | EMBO Journal | 1991 | 3,465 |
| 7 | Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences. | EMBO Journal | 1991 | 2,767 |
| 8 | Fission and selective fusion govern mitochondrial segregation and elimination by autophagy | EMBO Journal | 2008 | 2,669 |
| 9 | Two CD95 (APO-1/Fas) signaling pathways | EMBO Journal | 1998 | 2,654 |
| 10 | Mechanism of activation of protein kinase B by insulin and IGF-1. | EMBO Journal | 1996 | 2,611 |
| 11 | Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. | EMBO Journal | 1992 | 2,547 |
| 12 | Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase | EMBO Journal | 2004 | 2,473 |
| 13 | β-catenin is a target for the ubiquitin–proteasome pathway | EMBO Journal | 1997 | 2,313 |
| 14 | Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. | EMBO Journal | 1985 | 2,266 |
| 15 | The complete nucleotide sequence of the tobacco chloroplast genome: its gene organization and expression | EMBO Journal | 1986 | 2,205 |
| 16 | Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1 | EMBO Journal | 1998 | 2,172 |
| 17 | NEW EMBO MEMBERS' REVIEW: The ErbB signaling network: receptor heterodimerization in development and cancer | EMBO Journal | 2000 | 2,166 |
| 18 | Gene transfer into mouse lyoma cells by electroporation in high electric fields. | EMBO Journal | 1982 | 2,142 |
| 19 | The relation between the divergence of sequence and structure in proteins. | EMBO Journal | 1986 | 2,085 |
| 20 | MicroRNA maturation: stepwise processing and subcellular localization | EMBO Journal | 2002 | 2,053 |
| 21 | Endosome maturation | EMBO Journal | 2011 | 1,953 |
| 22 | Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 | EMBO Journal | 2007 | 1,874 |
| 23 | Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. | EMBO Journal | 1992 | 1,807 |
| 24 | Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. | EMBO Journal | 1995 | 1,801 |
| 25 | NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system | EMBO Journal | 2000 | 1,791 |
| 26 | VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells | EMBO Journal | 1999 | 1,785 |
| 27 | The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener | EMBO Journal | 2001 | 1,731 |
| 28 | Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene | EMBO Journal | 1998 | 1,650 |
| 29 | Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. | EMBO Journal | 1986 | 1,633 |
| 30 | Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells | EMBO Journal | 2001 | 1,633 |
| 31 | A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB | EMBO Journal | 2012 | 1,574 |
| 32 | Purification of a new neurotrophic factor from mammalian brain. | EMBO Journal | 1982 | 1,530 |
| 33 | NADPH oxidase AtrbohD and AtrbohF genes function in ROS-dependent ABA signaling in Arabidopsis | EMBO Journal | 2003 | 1,508 |
| 34 | Recognition of the polyubiquitin proteolytic signal | EMBO Journal | 2000 | 1,453 |
| 35 | Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. | EMBO Journal | 1987 | 1,410 |
| 36 | Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton | EMBO Journal | 1999 | 1,407 |
| 37 | Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. | EMBO Journal | 1991 | 1,394 |
| 38 | A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. | EMBO Journal | 1990 | 1,392 |
| 39 | HIF-1alpha is required for solid tumor formation and embryonic vascularization | EMBO Journal | 1998 | 1,374 |
| 40 | Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. | EMBO Journal | 1990 | 1,350 |
| 41 | ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling | EMBO Journal | 1997 | 1,341 |
| 42 | The many faces and functions of β-catenin | EMBO Journal | 2012 | 1,334 |
| 43 | Molecular tinkering of G protein-coupled receptors: an evolutionary success | EMBO Journal | 1999 | 1,300 |
| 44 | Molecular definitions of autophagy and related processes | EMBO Journal | 2017 | 1,293 |
| 45 | Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor | EMBO Journal | 2006 | 1,286 |
| 46 | A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. | EMBO Journal | 1996 | 1,273 |
| 47 | IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases | EMBO Journal | 1998 | 1,252 |
| 48 | The ubiquitin-proteasome pathway: on protein death and cell life | EMBO Journal | 1998 | 1,249 |
| 49 | Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate | EMBO Journal | 2001 | 1,242 |
| 50 | The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. | EMBO Journal | 1989 | 1,228 |
