| # | Title | Journal | Year | Citations |
|---|
| 1 | Physiochemical drug properties associated with in vivo toxicological outcomes | Bioorganic and Medicinal Chemistry Letters | 2008 | 749 |
| 2 | The use of spirocyclic scaffolds in drug discovery | Bioorganic and Medicinal Chemistry Letters | 2014 | 739 |
| 3 | Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids | Bioorganic and Medicinal Chemistry Letters | 1998 | 659 |
| 4 | Carbonic anhydrase inhibitors | Bioorganic and Medicinal Chemistry Letters | 2010 | 579 |
| 5 | Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction | Bioorganic and Medicinal Chemistry Letters | 1996 | 565 |
| 6 | The SARS-CoV-2 main protease as drug target | Bioorganic and Medicinal Chemistry Letters | 2020 | 550 |
| 7 | Studies leading to the identification of ZD1839 (iressa™): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer | Bioorganic and Medicinal Chemistry Letters | 2001 | 527 |
| 8 | Antioxidant activity of water-soluble chitosan derivatives | Bioorganic and Medicinal Chemistry Letters | 2001 | 503 |
| 9 | Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors | Bioorganic and Medicinal Chemistry Letters | 2005 | 479 |
| 10 | Rynaxypyr™: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator | Bioorganic and Medicinal Chemistry Letters | 2007 | 440 |
| 11 | The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K | Bioorganic and Medicinal Chemistry Letters | 2008 | 419 |
| 12 | Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics | Bioorganic and Medicinal Chemistry Letters | 2008 | 416 |
| 13 | The discovery of rofecoxib, [MK 966, VIOXX®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor | Bioorganic and Medicinal Chemistry Letters | 1999 | 413 |
| 14 | Aqua mediated synthesis of substituted 2-amino-4H-chromenes and in vitro study as antibacterial agents | Bioorganic and Medicinal Chemistry Letters | 2005 | 409 |
| 15 | 5-(3-carboxymethoxyphenyl)-2-(4,5-dimethylthiazolyl)-3-(4-sulfophenyl)tetrazolium, inner salt (MTS) and related analogs of 3-(4,5-dimethylthiazolyl)-2,5-diphenyltetrazolium bromide (MTT) reducing to purple water-soluble formazans As cell-viability indicators | Bioorganic and Medicinal Chemistry Letters | 1991 | 388 |
| 16 | Insecticidal anthranilic diamides: A new class of potent ryanodine receptor activators | Bioorganic and Medicinal Chemistry Letters | 2005 | 386 |
| 17 | MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products | Bioorganic and Medicinal Chemistry Letters | 1998 | 384 |
| 18 | GDC-0449—A potent inhibitor of the hedgehog pathway | Bioorganic and Medicinal Chemistry Letters | 2009 | 362 |
| 19 | Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries | Bioorganic and Medicinal Chemistry Letters | 2004 | 352 |
| 20 | Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation | Bioorganic and Medicinal Chemistry Letters | 2013 | 348 |
| 21 | A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain | Bioorganic and Medicinal Chemistry Letters | 2002 | 343 |
| 22 | Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13 | Bioorganic and Medicinal Chemistry Letters | 2012 | 342 |
| 23 | Synthesis and antidepressant activity of some 1,3,5-triphenyl-2-pyrazolines and 3-(2″-hydroxy naphthalen-1″-yl)-1,5-diphenyl-2-pyrazolines | Bioorganic and Medicinal Chemistry Letters | 2005 | 334 |
| 24 | Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α production | Bioorganic and Medicinal Chemistry Letters | 1999 | 331 |
| 25 | Prediction of drug solubility from Monte Carlo simulations | Bioorganic and Medicinal Chemistry Letters | 2000 | 327 |
| 26 | Potent antimitotic and cell growth inhibitory properties of substituted chalcones | Bioorganic and Medicinal Chemistry Letters | 1998 | 324 |
| 27 | Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains | Bioorganic and Medicinal Chemistry Letters | 2005 | 318 |
| 28 | Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells | Bioorganic and Medicinal Chemistry Letters | 2004 | 315 |
| 29 | Structure–activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors | Bioorganic and Medicinal Chemistry Letters | 2008 | 307 |
| 30 | Synthesis and anticonvulsant activity of new 2-substituted-5- [2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles and 1,2,4-triazoles | Bioorganic and Medicinal Chemistry Letters | 2004 | 304 |
| 31 | Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activity | Bioorganic and Medicinal Chemistry Letters | 2003 | 301 |
| 32 | Synthesis and QSAR studies of pyrimido[4,5-d]pyrimidine-2,5-dione derivatives as potential antimicrobial agents | Bioorganic and Medicinal Chemistry Letters | 2004 | 299 |
| 33 | Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum —The η-carbonic anhydrases | Bioorganic and Medicinal Chemistry Letters | 2014 | 297 |
| 34 | Friedländer reaction on 2-amino-3-cyano-4H-pyrans: Synthesis of derivatives of 4H-pyran [2,3-b] quinoline, new tacrine analogues | Bioorganic and Medicinal Chemistry Letters | 1997 | 292 |
| 35 | Synthesis and evaluation of anti-HIV activity of isatin β-thiosemicarbazone derivatives | Bioorganic and Medicinal Chemistry Letters | 2005 | 290 |
| 36 | Proteolytic studies of homologous peptide and N-substituted glycine peptoid oligomers | Bioorganic and Medicinal Chemistry Letters | 1994 | 289 |
| 37 | Antimalarial activity of phenazines from lapachol, β-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo | Bioorganic and Medicinal Chemistry Letters | 2004 | 289 |
| 38 | Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720 | Bioorganic and Medicinal Chemistry Letters | 1995 | 284 |
| 39 | Curcumin is a potent DNA hypomethylation agent | Bioorganic and Medicinal Chemistry Letters | 2009 | 284 |
| 40 | Synthesis and anti-pseudomonal activity of new 2-isocephems with a dihydroxypyridone moiety at C-7 | Bioorganic and Medicinal Chemistry Letters | 1994 | 280 |
| 41 | Identification of antitumor activity of pyrazole oxime ethers | Bioorganic and Medicinal Chemistry Letters | 2005 | 276 |
| 42 | Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents | Bioorganic and Medicinal Chemistry Letters | 2005 | 273 |
| 43 | Defining optimum lipophilicity and molecular weight ranges for drug candidates—Molecular weight dependent lower logD limits based on permeability | Bioorganic and Medicinal Chemistry Letters | 2009 | 271 |
| 44 | Synthesis and antifungal activity of 1,2,3-triazole containing fluconazole analogues | Bioorganic and Medicinal Chemistry Letters | 2009 | 269 |
| 45 | Synthesis of potent antitumor and antiviral benzofuran derivatives | Bioorganic and Medicinal Chemistry Letters | 2009 | 266 |
| 46 | Photochemical preparation of a pyridone containing tetracycle: A jak protein kinase inhibitor | Bioorganic and Medicinal Chemistry Letters | 2002 | 263 |
| 47 | Drugs, leads, and drug-likeness: an analysis of some recently launched drugs | Bioorganic and Medicinal Chemistry Letters | 2002 | 261 |
| 48 | Anti-AIDS agents 54. A potent anti-HIV chalcone and flavonoids from genus Desmos | Bioorganic and Medicinal Chemistry Letters | 2003 | 261 |
| 49 | Anti-HIV coumarins from calophyllum seed oil | Bioorganic and Medicinal Chemistry Letters | 1998 | 260 |
| 50 | Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues | Bioorganic and Medicinal Chemistry Letters | 2004 | 256 |
