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Top Articles

#TitleJournalYearCitations
1Physiochemical drug properties associated with in vivo toxicological outcomesBioorganic and Medicinal Chemistry Letters2008785
2The use of spirocyclic scaffolds in drug discoveryBioorganic and Medicinal Chemistry Letters2014782
3Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acidsBioorganic and Medicinal Chemistry Letters1998662
4The SARS-CoV-2 main protease as drug targetBioorganic and Medicinal Chemistry Letters2020586
5Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunctionBioorganic and Medicinal Chemistry Letters1996575
6Studies leading to the identification of ZD1839 (iressa™): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancerBioorganic and Medicinal Chemistry Letters2001535
7Antioxidant activity of water-soluble chitosan derivativesBioorganic and Medicinal Chemistry Letters2001514
8Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitorsBioorganic and Medicinal Chemistry Letters2005484
9Rynaxypyr™: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activatorBioorganic and Medicinal Chemistry Letters2007454
10Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomicsBioorganic and Medicinal Chemistry Letters2008437
11The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin KBioorganic and Medicinal Chemistry Letters2008428
12Aqua mediated synthesis of substituted 2-amino-4H-chromenes and in vitro study as antibacterial agentsBioorganic and Medicinal Chemistry Letters2005422
13The discovery of rofecoxib, [MK 966, VIOXX®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitorBioorganic and Medicinal Chemistry Letters1999417
14Insecticidal anthranilic diamides: A new class of potent ryanodine receptor activatorsBioorganic and Medicinal Chemistry Letters2005396
155-(3-carboxymethoxyphenyl)-2-(4,5-dimethylthiazolyl)-3-(4-sulfophenyl)tetrazolium, inner salt (MTS) and related analogs of 3-(4,5-dimethylthiazolyl)-2,5-diphenyltetrazolium bromide (MTT) reducing to purple water-soluble formazans As cell-viability indicatorsBioorganic and Medicinal Chemistry Letters1991392
16MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization productsBioorganic and Medicinal Chemistry Letters1998386
17Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluationBioorganic and Medicinal Chemistry Letters2013372
18Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone librariesBioorganic and Medicinal Chemistry Letters2004367
19GDC-0449—A potent inhibitor of the hedgehog pathwayBioorganic and Medicinal Chemistry Letters2009363
20Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13Bioorganic and Medicinal Chemistry Letters2012359
21A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brainBioorganic and Medicinal Chemistry Letters2002348
22Synthesis and antidepressant activity of some 1,3,5-triphenyl-2-pyrazolines and 3-(2″-hydroxy naphthalen-1″-yl)-1,5-diphenyl-2-pyrazolinesBioorganic and Medicinal Chemistry Letters2005339
23Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α productionBioorganic and Medicinal Chemistry Letters1999334
24Prediction of drug solubility from Monte Carlo simulationsBioorganic and Medicinal Chemistry Letters2000331
25Potent antimitotic and cell growth inhibitory properties of substituted chalconesBioorganic and Medicinal Chemistry Letters1998330
26Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chainsBioorganic and Medicinal Chemistry Letters2005323
27Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cellsBioorganic and Medicinal Chemistry Letters2004316
28Synthesis and anticonvulsant activity of new 2-substituted-5- [2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles and 1,2,4-triazolesBioorganic and Medicinal Chemistry Letters2004316
29Structure–activity relationship study of bone morphogenetic protein (BMP) signaling inhibitorsBioorganic and Medicinal Chemistry Letters2008315
30Synthesis and QSAR studies of pyrimido[4,5-d]pyrimidine-2,5-dione derivatives as potential antimicrobial agentsBioorganic and Medicinal Chemistry Letters2004309
31Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activityBioorganic and Medicinal Chemistry Letters2003302
32Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum —The η-carbonic anhydrasesBioorganic and Medicinal Chemistry Letters2014302
33Synthesis and evaluation of anti-HIV activity of isatin β-thiosemicarbazone derivativesBioorganic and Medicinal Chemistry Letters2005299
34Friedländer reaction on 2-amino-3-cyano-4H-pyrans: Synthesis of derivatives of 4H-pyran [2,3-b] quinoline, new tacrine analoguesBioorganic and Medicinal Chemistry Letters1997296
35Proteolytic studies of homologous peptide and N-substituted glycine peptoid oligomersBioorganic and Medicinal Chemistry Letters1994295
36Antimalarial activity of phenazines from lapachol, β-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivoBioorganic and Medicinal Chemistry Letters2004294
37Curcumin is a potent DNA hypomethylation agentBioorganic and Medicinal Chemistry Letters2009292
38Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720Bioorganic and Medicinal Chemistry Letters1995287
39Synthesis and anti-pseudomonal activity of new 2-isocephems with a dihydroxypyridone moiety at C-7Bioorganic and Medicinal Chemistry Letters1994284
40Identification of antitumor activity of pyrazole oxime ethersBioorganic and Medicinal Chemistry Letters2005283
41Defining optimum lipophilicity and molecular weight ranges for drug candidates—Molecular weight dependent lower logD limits based on permeabilityBioorganic and Medicinal Chemistry Letters2009280
42Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agentsBioorganic and Medicinal Chemistry Letters2005279
43Synthesis and antifungal activity of 1,2,3-triazole containing fluconazole analoguesBioorganic and Medicinal Chemistry Letters2009274
44Synthesis of potent antitumor and antiviral benzofuran derivativesBioorganic and Medicinal Chemistry Letters2009268
45Drugs, leads, and drug-likeness: an analysis of some recently launched drugsBioorganic and Medicinal Chemistry Letters2002265
46Anti-HIV coumarins from calophyllum seed oilBioorganic and Medicinal Chemistry Letters1998263
47Photochemical preparation of a pyridone containing tetracycle: A jak protein kinase inhibitorBioorganic and Medicinal Chemistry Letters2002263
48Anti-AIDS agents 54. A potent anti-HIV chalcone and flavonoids from genus DesmosBioorganic and Medicinal Chemistry Letters2003263
49The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-lifeBioorganic and Medicinal Chemistry Letters2010263
50Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analoguesBioorganic and Medicinal Chemistry Letters2004261