1 | APACHE II | Critical Care Medicine | 1985 | 15,910 |
2 | Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care | Critical Care Medicine | 2001 | 8,669 |
3 | Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 | Critical Care Medicine | 2008 | 7,380 |
4 | Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock* | Critical Care Medicine | 2006 | 7,360 |
5 | Surviving Sepsis Campaign | Critical Care Medicine | 2013 | 6,472 |
6 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference | Critical Care Medicine | 2003 | 5,372 |
7 | Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock | Critical Care Medicine | 2004 | 4,637 |
8 | Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units | Critical Care Medicine | 1998 | 3,798 |
9 | Multiple Organ Dysfunction Score | Critical Care Medicine | 1995 | 3,401 |
10 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit | Critical Care Medicine | 2013 | 3,200 |
11 | APACHE II-A Severity of Disease Classification System | Critical Care Medicine | 1986 | 3,165 |
12 | Evaluation of delirium in critically ill patients: Validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) | Critical Care Medicine | 2001 | 2,662 |
13 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 | Critical Care Medicine | 2017 | 2,464 |
14 | Sepsis in European intensive care units: Results of the SOAP study* | Critical Care Medicine | 2006 | 2,459 |
15 | Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU | Critical Care Medicine | 2018 | 2,420 |
16 | APACHE—acute physiology and chronic health evaluation: a physiologically based classification system | Critical Care Medicine | 1981 | 2,408 |
17 | Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients* | Critical Care Medicine | 2002 | 2,074 |
18 | Assessment of cardiac output from systemic arterial pressure in humans | Critical Care Medicine | 2002 | 2,065 |
19 | Improving long-term outcomes after discharge from intensive care unit | Critical Care Medicine | 2012 | 2,010 |
20 | Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult | Critical Care Medicine | 2002 | 1,978 |
21 | Outcome benefit of intensive insulin therapy in the critically ill: Insulin dose versus glycemic control* | Critical Care Medicine | 2003 | 1,973 |
22 | Efficacy of red blood cell transfusion in the critically ill: A systematic review of the literature* | Critical Care Medicine | 2008 | 1,920 |
23 | Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: A multiple-center epidemiological study* | Critical Care Medicine | 2005 | 1,897 |
24 | The CRIT Study: Anemia and blood transfusion in the critically ill—Current clinical practice in the United States* | Critical Care Medicine | 2004 | 1,857 |
25 | Use of intensive care at the end of life in the United States: An epidemiologic study* | Critical Care Medicine | 2004 | 1,747 |
26 | Dynamic changes in arterial waveform derived variables and fluid responsiveness in mechanically ventilated patients: A systematic review of the literature* | Critical Care Medicine | 2009 | 1,733 |
27 | Glycemic variability: A strong independent predictor of mortality in critically ill patients* | Critical Care Medicine | 2008 | 1,728 |
28 | Early lactate clearance is associated with improved outcome in severe sepsis and septic shock* | Critical Care Medicine | 2004 | 1,640 |
29 | Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care* | Critical Care Medicine | 2009 | 1,604 |
30 | PRISM III | Critical Care Medicine | 1996 | 1,586 |
31 | Delirium as a predictor of long-term cognitive impairment in survivors of critical illness | Critical Care Medicine | 2010 | 1,546 |
32 | Acute Physiology and Chronic Health Evaluation (APACHE) IV: Hospital mortality assessment for today’s critically ill patients* | Critical Care Medicine | 2006 | 1,533 |
33 | The effect of age on the development and outcome of adult sepsis* | Critical Care Medicine | 2006 | 1,482 |
34 | Multiparameter Intelligent Monitoring in Intensive Care II: A public-access intensive care unit database* | Critical Care Medicine | 2011 | 1,471 |
35 | Nosocomial infections in medical intensive care units in the United States | Critical Care Medicine | 1999 | 1,471 |
36 | Simplified Therapeutic Intervention Scoring System | Critical Care Medicine | 1996 | 1,444 |
37 | Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: Consensus statements from an international task force by the American College of Critical Care Medicine | Critical Care Medicine | 2008 | 1,425 |
38 | The Critical Care Safety Study: The incidence and nature of adverse events and serious medical errors in intensive care* | Critical Care Medicine | 2005 | 1,404 |
39 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021 | Critical Care Medicine | 2021 | 1,350 |
40 | Fluid resuscitation in septic shock: A positive fluid balance and elevated central venous pressure are associated with increased mortality* | Critical Care Medicine | 2011 | 1,311 |
41 | Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome | Critical Care Medicine | 1999 | 1,310 |
42 | Refinement, scoring, and validation of the Family Satisfaction in the Intensive Care Unit (FS-ICU) survey* | Critical Care Medicine | 2007 | 1,298 |
43 | A prospective, randomized, study comparing early percutaneous dilational tracheotomy to prolonged translaryngeal intubation (delayed tracheotomy) in critically ill medical patients* | Critical Care Medicine | 2004 | 1,294 |
44 | Memory, delusions, and the development of acute posttraumatic stress disorder-related symptoms after intensive care | Critical Care Medicine | 2001 | 1,279 |
45 | The LRINEC (Laboratory Risk Indicator for Necrotizing Fasciitis) score: A tool for distinguishing necrotizing fasciitis from other soft tissue infections* | Critical Care Medicine | 2004 | 1,278 |
46 | Findings of the First Consensus Conference on Medical Emergency Teams* | Critical Care Medicine | 2006 | 1,274 |
47 | Passive leg raising predicts fluid responsiveness in the critically ill* | Critical Care Medicine | 2006 | 1,268 |
48 | Forgoing life support in western European intensive care units | Critical Care Medicine | 1999 | 1,264 |
49 | Pediatric risk of mortality (PRISM) score | Critical Care Medicine | 1988 | 1,261 |
50 | Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction | Critical Care Medicine | 1999 | 1,255 |