| 1 | Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis | Chest | 1992 | 9,749 |
| 2 | Refining Clinical Risk Stratification for Predicting Stroke and Thromboembolism in Atrial Fibrillation Using a Novel Risk Factor-Based Approach | Chest | 2010 | 6,289 |
| 3 | Prevention of Venous Thromboembolism | Chest | 2004 | 5,683 |
| 4 | Revisions in the International System for Staging Lung Cancer | Chest | 1997 | 4,451 |
| 5 | Antithrombotic Therapy for VTE Disease | Chest | 2016 | 4,439 |
| 6 | A Novel User-Friendly Score (HAS-BLED) To Assess 1-Year Risk of Major Bleeding in Patients With Atrial Fibrillation | Chest | 2010 | 4,190 |
| 7 | Antithrombotic Therapy for VTE Disease | Chest | 2012 | 3,951 |
| 8 | Prevention of Venous Thromboembolism | Chest | 2008 | 3,881 |
| 9 | The APACHE III Prognostic System | Chest | 1991 | 3,645 |
| 10 | International Classification of Sleep Disorders-Third Edition | Chest | 2014 | 3,031 |
| 11 | The APACHE III Prognostic System | Chest | 1992 | 2,781 |
| 12 | Prospective Trial of Supranormal Values of Survivors as Therapeutic Goals in High-Risk Surgical Patients | Chest | 1988 | 2,337 |
| 13 | Relevance of Lung Ultrasound in the Diagnosis of Acute Respiratory Failure*: The BLUE Protocol | Chest | 2008 | 2,316 |
| 14 | Prevention of Venous Thromboembolism | Chest | 2001 | 2,194 |
| 15 | Initiation of Inappropriate Antimicrobial Therapy Results in a Fivefold Reduction of Survival in Human Septic Shock | Chest | 2009 | 2,029 |
| 16 | Elective Percutaneous Dilatational Tracheostomy | Chest | 1985 | 2,017 |
| 17 | Prevention of VTE in Nonorthopedic Surgical Patients | Chest | 2012 | 2,007 |
| 18 | Pharmacology and Management of the Vitamin K Antagonists | Chest | 2008 | 1,988 |
| 19 | C-Reactive Protein Levels Correlate With Mortality and Organ Failure in Critically Ill Patientsa | Chest | 2003 | 1,944 |
| 20 | Prevention of VTE in Orthopedic Surgery Patients | Chest | 2012 | 1,938 |
| 21 | Prevention of VTE in Nonsurgical Patients | Chest | 2012 | 1,898 |
| 22 | Antithrombotic Therapy for Venous Thromboembolic Disease | Chest | 2008 | 1,896 |
| 23 | Proinflammatory Cytokines | Chest | 2000 | 1,865 |
| 24 | Inadequate Antimicrobial Treatment of Infections | Chest | 1999 | 1,791 |
| 25 | Blood Lactate Levels Are Superior to Oxygen-Derived Variables in Predicting Outcome in Human Septic Shock | Chest | 1991 | 1,686 |
| 26 | The Influence of Inadequate Antimicrobial Treatment of Bloodstream Infections on Patient Outcomes in the ICU Setting | Chest | 2000 | 1,681 |
| 27 | Evaluation of Clinical Methods for Rating Dyspnea | Chest | 1988 | 1,565 |
| 28 | Perioperative Management of Antithrombotic Therapy | Chest | 2012 | 1,540 |
| 29 | A New International Staging System for Lung Cancer | Chest | 1986 | 1,531 |
| 30 | VTE, Thrombophilia, Antithrombotic Therapy, and Pregnancy | Chest | 2012 | 1,529 |
| 31 | Executive Summary | Chest | 2012 | 1,511 |
| 32 | Mortality and Apnea Index in Obstructive Sleep Apnea | Chest | 1988 | 1,493 |
| 33 | Anti-Inflammatory Cytokines | Chest | 2000 | 1,486 |
| 34 | Predicting Fluid Responsiveness in ICU Patients | Chest | 2002 | 1,429 |
| 35 | Does Central Venous Pressure Predict Fluid Responsiveness?*: A Systematic Review of the Literature and the Tale of Seven Mares | Chest | 2008 | 1,426 |
| 36 | The Eighth Edition Lung Cancer Stage Classification | Chest | 2017 | 1,410 |
| 37 | Oral Anticoagulant Therapy | Chest | 2012 | 1,405 |
| 38 | Methods for Staging Non-small Cell Lung Cancer | Chest | 2013 | 1,392 |
| 39 | Regional Lymph Node Classification for Lung Cancer Staging | Chest | 1997 | 1,388 |
| 40 | Antithrombotic Therapy in Neonates and Children | Chest | 2012 | 1,373 |
| 41 | Effect of Failed Extubation on the Outcome of Mechanical Ventilation | Chest | 1997 | 1,356 |
| 42 | Heparin and Low-Molecular-Weight Heparin Mechanisms of Action, Pharmacokinetics, Dosing, Monitoring, Efficacy, and Safety | Chest | 2001 | 1,351 |
| 43 | Evaluation of Individuals With Pulmonary Nodules: When Is It Lung Cancer? | Chest | 2013 | 1,298 |
| 44 | Cross-Sectional Studies | Chest | 2020 | 1,278 |
| 45 | Treatment of Stage I and II Non-small Cell Lung Cancer | Chest | 2013 | 1,267 |
| 46 | The Impact of Critical Illness on Perceived Health-Related Quality of Life During ICU Treatment, Hospital Stay, and After Hospital Discharge | Chest | 2008 | 1,265 |
| 47 | The Measurement of Dyspnea | Chest | 1984 | 1,231 |
| 48 | Comparison of the Sp o 2 /F io 2 Ratio and the Pa o 2 /F io 2 Ratio in Patients With Acute Lung Injury or ARDS | Chest | 2007 | 1,228 |
| 49 | Antithrombotic Therapy for Venous Thromboembolic Disease | Chest | 2004 | 1,221 |
| 50 | Pulmonary Rehabilitation | Chest | 2007 | 1,214 |