| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis | Chest | 1992 | 9,453 |
| 2 | Refining Clinical Risk Stratification for Predicting Stroke and Thromboembolism in Atrial Fibrillation Using a Novel Risk Factor-Based Approach | Chest | 2010 | 5,842 |
| 3 | Revisions in the International System for Staging Lung Cancer | Chest | 1997 | 4,410 |
| 4 | Antithrombotic Therapy for VTE Disease | Chest | 2016 | 4,169 |
| 5 | A Novel User-Friendly Score (HAS-BLED) To Assess 1-Year Risk of Major Bleeding in Patients With Atrial Fibrillation | Chest | 2010 | 3,920 |
| 6 | Antithrombotic Therapy for VTE Disease | Chest | 2012 | 3,808 |
| 7 | The APACHE III Prognostic System | Chest | 1991 | 3,531 |
| 8 | The APACHE III Prognostic System | Chest | 1992 | 2,781 |
| 9 | International Classification of Sleep Disorders-Third Edition | Chest | 2014 | 2,378 |
| 10 | Prospective Trial of Supranormal Values of Survivors as Therapeutic Goals in High-Risk Surgical Patients | Chest | 1988 | 2,309 |
| 11 | Relevance of Lung Ultrasound in the Diagnosis of Acute Respiratory Failure*: The BLUE Protocol | Chest | 2008 | 2,172 |
| 12 | Elective Percutaneous Dilatational Tracheostomy | Chest | 1985 | 1,972 |
| 13 | Initiation of Inappropriate Antimicrobial Therapy Results in a Fivefold Reduction of Survival in Human Septic Shock | Chest | 2009 | 1,969 |
| 14 | Pharmacology and Management of the Vitamin K Antagonists | Chest | 2008 | 1,946 |
| 15 | C-Reactive Protein Levels Correlate With Mortality and Organ Failure in Critically Ill Patientsa | Chest | 2003 | 1,921 |
| 16 | Prevention of VTE in Nonorthopedic Surgical Patients | Chest | 2012 | 1,874 |
| 17 | Antithrombotic Therapy for Venous Thromboembolic Disease | Chest | 2008 | 1,866 |
| 18 | Prevention of VTE in Nonsurgical Patients | Chest | 2012 | 1,826 |
| 19 | Prevention of VTE in Orthopedic Surgery Patients | Chest | 2012 | 1,783 |
| 20 | Inadequate Antimicrobial Treatment of Infections | Chest | 1999 | 1,753 |
| 21 | Proinflammatory Cytokines | Chest | 2000 | 1,737 |
| 22 | Blood Lactate Levels Are Superior to Oxygen-Derived Variables in Predicting Outcome in Human Septic Shock | Chest | 1991 | 1,668 |
| 23 | The Influence of Inadequate Antimicrobial Treatment of Bloodstream Infections on Patient Outcomes in the ICU Setting | Chest | 2000 | 1,657 |
| 24 | A New International Staging System for Lung Cancer | Chest | 1986 | 1,501 |
| 25 | Perioperative Management of Antithrombotic Therapy | Chest | 2012 | 1,489 |
| 26 | Mortality and Apnea Index in Obstructive Sleep Apnea | Chest | 1988 | 1,476 |
| 27 | VTE, Thrombophilia, Antithrombotic Therapy, and Pregnancy | Chest | 2012 | 1,457 |
| 28 | Evaluation of Clinical Methods for Rating Dyspnea | Chest | 1988 | 1,394 |
| 29 | Predicting Fluid Responsiveness in ICU Patients | Chest | 2002 | 1,384 |
| 30 | Does Central Venous Pressure Predict Fluid Responsiveness?*: A Systematic Review of the Literature and the Tale of Seven Mares | Chest | 2008 | 1,368 |
| 31 | Anti-Inflammatory Cytokines | Chest | 2000 | 1,365 |
| 32 | Regional Lymph Node Classification for Lung Cancer Staging | Chest | 1997 | 1,357 |
| 33 | Oral Anticoagulant Therapy | Chest | 2012 | 1,347 |
| 34 | Effect of Failed Extubation on the Outcome of Mechanical Ventilation | Chest | 1997 | 1,318 |
| 35 | Heparin and Low-Molecular-Weight Heparin Mechanisms of Action, Pharmacokinetics, Dosing, Monitoring, Efficacy, and Safety | Chest | 2001 | 1,293 |
| 36 | Antithrombotic Therapy in Neonates and Children | Chest | 2012 | 1,266 |
| 37 | Methods for Staging Non-small Cell Lung Cancer | Chest | 2013 | 1,262 |
| 38 | The Impact of Critical Illness on Perceived Health-Related Quality of Life During ICU Treatment, Hospital Stay, and After Hospital Discharge | Chest | 2008 | 1,261 |
| 39 | Antithrombotic Therapy for Venous Thromboembolic Disease | Chest | 2004 | 1,217 |
| 40 | The Measurement of Dyspnea | Chest | 1984 | 1,203 |
| 41 | High-Frequency Oscillatory Ventilation in Adults | Chest | 2004 | 1,201 |
| 42 | The Eighth Edition Lung Cancer Stage Classification | Chest | 2017 | 1,195 |
| 43 | Comparison of the Sp o 2 /F io 2 Ratio and the Pa o 2 /F io 2 Ratio in Patients With Acute Lung Injury or ARDS | Chest | 2007 | 1,170 |
| 44 | Treatment of Stage I and II Non-small Cell Lung Cancer | Chest | 2013 | 1,157 |
| 45 | Grading Strength of Recommendations and Quality of Evidence in Clinical Guidelines | Chest | 2006 | 1,149 |
| 46 | Management of Spontaneous Pneumothorax | Chest | 2001 | 1,141 |
| 47 | Evaluation of Individuals With Pulmonary Nodules: When Is It Lung Cancer? | Chest | 2013 | 1,138 |
| 48 | Evidence-Based Management of Anticoagulant Therapy | Chest | 2012 | 1,121 |
| 49 | Epidemiology and Outcomes of Ventilator-Associated Pneumonia in a Large US Database | Chest | 2002 | 1,101 |
| 50 | The Pharmacology and Management of the Vitamin K Antagonists | Chest | 2004 | 1,099 |
