| # | Title | Journal | Year | Citations |
|---|
| 1 | Atezolizumab in combination with carboplatin plus nab-paclitaxel chemotherapy compared with chemotherapy alone as first-line treatment for metastatic non-squamous non-small-cell lung cancer (IMpower130): a multicentre, randomised, open-label, phase 3 trial | Lancet Oncology, The | 2019 | 1,133 |
| 2 | Pembrolizumab or Placebo Plus Etoposide and Platinum as First-Line Therapy for Extensive-Stage Small-Cell Lung Cancer: Randomized, Double-Blind, Phase III KEYNOTE-604 Study | Journal of Clinical Oncology | 2020 | 410 |
| 3 | Improved diagnostic yield compared with targeted gene sequencing panels suggests a role for whole-genome sequencing as a first-tier genetic test | Genetics in Medicine | 2018 | 404 |
| 4 | Atezolizumab in Combination With Carboplatin and Nab-Paclitaxel in Advanced Squamous NSCLC (IMpower131): Results From a Randomized Phase III Trial | Journal of Thoracic Oncology | 2020 | 379 |
| 5 | Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial | BMJ, The | 2021 | 250 |
| 6 | South Asians and Cardiovascular Risk | Circulation | 2006 | 241 |
| 7 | Cancer-related fatigue: ESMO Clinical Practice Guidelines for diagnosis and treatment | Annals of Oncology | 2020 | 233 |
| 8 | Efficacy of 8 Weeks of Sofosbuvir, Velpatasvir, and Voxilaprevir in Patients With Chronic HCV Infection: 2 Phase 3 Randomized Trials | Gastroenterology | 2017 | 215 |
| 9 | Effect of Sotrovimab on Hospitalization or Death Among High-risk Patients With Mild to Moderate COVID-19 | JAMA - Journal of the American Medical Association | 2022 | 203 |
| 10 | Identification of a Novel Hepatitis C Virus Genotype From Punjab, India: Expanding Classification of Hepatitis C Virus Into 8 Genotypes | Journal of Infectious Diseases | 2018 | 202 |
| 11 | Effect of Supplemental Donor Human Milk Compared With Preterm Formula on Neurodevelopment of Very Low-Birth-Weight Infants at 18 Months | JAMA - Journal of the American Medical Association | 2016 | 190 |
| 12 | International Validity of the HOSPITAL Score to Predict 30-Day Potentially Avoidable Hospital Readmissions | JAMA Internal Medicine | 2016 | 184 |
| 13 | Effect of Patient-Centered Transitional Care Services on Clinical Outcomes in Patients Hospitalized for Heart Failure | JAMA - Journal of the American Medical Association | 2019 | 176 |
| 14 | Burning mouth syndrome | American Family Physician | 2002 | 176 |
| 15 | Adult Asthma Consensus Guidelines Update 2003 | Canadian Respiratory Journal | 2004 | 171 |
| 16 | IMpower131: Primary PFS and safety analysis of a randomized phase III study of atezolizumab + carboplatin + paclitaxel or nab-paclitaxel vs carboplatin + nab-paclitaxel as 1L therapy in advanced squamous NSCLC. | Journal of Clinical Oncology | 2018 | 153 |
| 17 | The Importance of Frailty in the Assessment of Influenza Vaccine Effectiveness Against Influenza-Related Hospitalization in Elderly People | Journal of Infectious Diseases | 2017 | 133 |
| 18 | Is South Asian ethnicity an independent cardiovascular risk factor? | Canadian Journal of Cardiology | 2006 | 132 |
| 19 | How the COVID-19 pandemic will change the future of critical care | Intensive Care Medicine | 2021 | 132 |
| 20 | Outbreak of Carbapenem-Resistant Enterobacteriaceae Containing blaNDM-1, Ontario, Canada | Clinical Infectious Diseases | 2012 | 109 |
| 21 | The Ontario Uterine Fibroid Embolization Trial. Part 1. Baseline patient characteristics, fibroid burden, and impact on life | Fertility and Sterility | 2003 | 106 |
| 22 | High Prevalence of ST131 Isolates Producing CTX-M-15 and CTX-M-14 among Extended-Spectrum-β-Lactamase-Producing Escherichia coli Isolates from Canada | Antimicrobial Agents and Chemotherapy | 2010 | 101 |
| 23 | Nutrient enrichment of human milk with human and bovine milk–based fortifiers for infants born weighing <1250 g: a randomized clinical trial | American Journal of Clinical Nutrition | 2018 | 97 |
| 24 | Initial Findings From the North American COVID-19 Myocardial Infarction Registry | Journal of the American College of Cardiology | 2021 | 96 |
| 25 | The Ontario Asthma Regional Variation Study | Chest | 2006 | 95 |
| 26 | Sofosbuvir/velpatasvir for 12 weeks in hepatitis C virus-infected patients with end-stage renal disease undergoing dialysis | Journal of Hepatology | 2019 | 93 |
| 27 | Multiple dysregulated pathways in nasopharyngeal carcinoma revealed by gene expression profiling | International Journal of Cancer | 2006 | 87 |
| 28 | Symptoms Associated with Malignant Wounds: A Prospective Case Series | Journal of Pain and Symptom Management | 2009 | 78 |
| 29 | NRG1 fusion-driven tumors: biology, detection, and the therapeutic role of afatinib and other ErbB-targeting agents | Annals of Oncology | 2020 | 75 |
| 30 | Variations and Gaps in Management of Acute Asthma in Ontario Emergency Departments | Chest | 2009 | 73 |
| 31 | Stand Up and Be Counted: Measuring and Mapping the Rheumatology Workforce in Canada | Journal of Rheumatology | 2017 | 72 |
| 32 | Identification of 19 Novel Hepatitis C Virus Subtypes—Further Expanding HCV Classification | Open Forum Infectious Diseases | 2019 | 72 |
| 33 | Implementation of Clinical Practice Guidelines for Ventilator-Associated Pneumonia | Critical Care Medicine | 2013 | 70 |
| 34 | Molecular characterization of NRXN1 deletions from 19,263 clinical microarray cases identifies exons important for neurodevelopmental disease expression | Genetics in Medicine | 2017 | 70 |
| 35 | Technical Results and Effects of Operator Experience on Uterine Artery Embolization for Fibroids: The Ontario Uterine Fibroid Embolization Trial | Journal of Vascular and Interventional Radiology | 2003 | 69 |
| 36 | Effectiveness of Influenza Vaccination on Hospitalizations and Risk Factors for Severe Outcomes in Hospitalized Patients With COPD | Chest | 2019 | 67 |
| 37 | Global real‐world evidence of sofosbuvir/velpatasvir as simple, effective HCV treatment: Analysis of 5552 patients from 12 cohorts | Liver International | 2020 | 66 |
| 38 | Cerebral blastomycosis: a case series incorporating voriconazole in the treatment regimen | Medical Mycology | 2006 | 65 |
| 39 | Wounds in advanced illness: a prevalence and incidence study based on a prospective case series | International Wound Journal | 2008 | 60 |
| 40 | Complementary and Alternative Medicines (CAM) in the Management of Asthma: An Examination of the Evidence | Journal of Asthma | 2004 | 59 |
| 41 | The Incidence of Irritable Bowel Syndrome Among Community Subjects With Previous Acute Enteric Infection | Digestive Diseases and Sciences | 2006 | 58 |
| 42 | Perspectives on Treatment Advances for Stage III Locally Advanced Unresectable Non-Small-Cell Lung Cancer | Current Oncology | 2019 | 56 |
| 43 | Burning Mouth Syndrome | Oral and Maxillofacial Surgery Clinics of North America | 2016 | 55 |
| 44 | Antimicrobial Stewardship and Intensive Care Unit Mortality: A Systematic Review | Clinical Infectious Diseases | 2019 | 55 |
| 45 | Vitamin D poisoning by table sugar | Lancet, The | 2002 | 54 |
| 46 | Influenza vaccine effectiveness to prevent influenza-related hospitalizations and serious outcomes in Canadian adults over the 2011/12 through 2013/14 influenza seasons: A pooled analysis from the Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS Network) | Vaccine | 2018 | 52 |
| 47 | Atezolizumab versus chemotherapy in advanced or metastatic NSCLC with high blood-based tumor mutational burden: primary analysis of BFAST cohort C randomized phase 3 trial | Nature Medicine | 2022 | 47 |
| 48 | Adjunctive nabilone in cancer pain and symptom management: a prospective observational study using propensity scoring | The Journal of Supportive Oncology | 2008 | 46 |
| 49 | Long-term outcomes after adjuvant treatment of sequential versus combination docetaxel with doxorubicin and cyclophosphamide in node-positive breast cancer: BCIRG-005 randomized trial | Annals of Oncology | 2016 | 45 |
| 50 | Effective diversity, equity, and inclusion practices | Healthcare Management Forum | 2018 | 43 |
