| # | Title | Journal | Year | Citations |
|---|
| 1 | Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock | New England Journal of Medicine | 2001 | 12,968 |
| 2 | Rapid Measurement of B-Type Natriuretic Peptide in the Emergency Diagnosis of Heart Failure | New England Journal of Medicine | 2002 | 3,057 |
| 3 | The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma | American Journal of Surgical Pathology | 2005 | 2,334 |
| 4 | An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics | Cell | 2018 | 2,277 |
| 5 | Reliability and Validity of the Ocular Surface Disease Index | JAMA Ophthalmology | 2000 | 2,194 |
| 6 | CD4+ Count–Guided Interruption of Antiretroviral Treatment | New England Journal of Medicine | 2006 | 2,099 |
| 7 | Trauma and Posttraumatic Stress Disorder in the Community | Archives of General Psychiatry | 1998 | 2,031 |
| 8 | The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes | Arthritis and Rheumatism | 1999 | 1,885 |
| 9 | The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia | New England Journal of Medicine | 2003 | 1,780 |
| 10 | Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma | Cell | 2016 | 1,695 |
| 11 | Efficacy and Safety of Exercise Training in Patients With Chronic Heart Failure | JAMA - Journal of the American Medical Association | 2009 | 1,694 |
| 12 | Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection | New England Journal of Medicine | 2013 | 1,605 |
| 13 | Boceprevir for Previously Treated Chronic HCV Genotype 1 Infection | New England Journal of Medicine | 2011 | 1,538 |
| 14 | Multidetector Computed Tomography for Acute Pulmonary Embolism | New England Journal of Medicine | 2006 | 1,455 |
| 15 | Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation | Cell | 2018 | 1,417 |
| 16 | The World Health Organization/International Society of Urological Pathology Consensus Classification of Urothelial (Transitional Cell) Neoplasms of the Urinary Bladder | American Journal of Surgical Pathology | 1998 | 1,417 |
| 17 | Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss. | Journal of Clinical Investigation | 1983 | 1,396 |
| 18 | A Randomized Trial of Aspirin to Prevent Colorectal Adenomas | New England Journal of Medicine | 2003 | 1,358 |
| 19 | Breast cancer statistics, 2017, racial disparity in mortality by state | Ca-A Cancer Journal for Clinicians | 2017 | 1,264 |
| 20 | Severely Suppressed Bone Turnover: A Potential Complication of Alendronate Therapy | Journal of Clinical Endocrinology and Metabolism | 2005 | 1,229 |
| 21 | Effects of Controlled-Release Metoprolol on Total Mortality, Hospitalizations, and Well-being in Patients With Heart Failure | JAMA - Journal of the American Medical Association | 2000 | 1,193 |
| 22 | COVID-19–associated Acute Hemorrhagic Necrotizing Encephalopathy: Imaging Features | Radiology | 2020 | 1,169 |
| 23 | Intravenous Administration of Human Umbilical Cord Blood Reduces Behavioral Deficits After Stroke in Rats | Stroke | 2001 | 1,153 |
| 24 | The Use of Computed Tomography in Pediatrics and the Associated Radiation Exposure and Estimated Cancer Risk | JAMA Pediatrics | 2013 | 1,123 |
| 25 | VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain | Journal of Clinical Investigation | 2000 | 1,115 |
| 26 | Effect of Screening on Ovarian Cancer Mortality | JAMA - Journal of the American Medical Association | 2011 | 1,080 |
| 27 | Improved reliability of the NIH Stroke Scale using video training. NINDS TPA Stroke Study Group. | Stroke | 1994 | 1,042 |
| 28 | Telaprevir with Peginterferon and Ribavirin for Chronic HCV Genotype 1 Infection | New England Journal of Medicine | 2009 | 1,038 |
| 29 | Risk of Bleeding With 2 Doses of Dabigatran Compared With Warfarin in Older and Younger Patients With Atrial Fibrillation | Circulation | 2011 | 1,035 |
| 30 | Sofosbuvir for Hepatitis C Genotype 2 or 3 in Patients without Treatment Options | New England Journal of Medicine | 2013 | 992 |
| 31 | Guidelines of care for the management of acne vulgaris | Journal of the American Academy of Dermatology | 2016 | 980 |
| 32 | Effects of Early Enteral Feeding on the Outcome of Critically Ill Mechanically Ventilated Medical Patients | Chest | 2006 | 922 |
| 33 | Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy | Nature | 2015 | 897 |
| 34 | Racial Differences in Sarcoidosis Incidence: A 5-Year Study in a Health Maintenance Organization | American Journal of Epidemiology | 1997 | 869 |
| 35 | Human marrow stromal cell therapy for stroke in rat | Neurology | 2002 | 862 |
| 36 | Colorectal-Cancer Incidence and Mortality with Screening Flexible Sigmoidoscopy | New England Journal of Medicine | 2012 | 851 |
| 37 | Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation | Nature Medicine | 2016 | 844 |
| 38 | Previous Exposure to Trauma and PTSD Effects of Subsequent Trauma: Results From the Detroit Area Survey of Trauma | American Journal of Psychiatry | 1999 | 832 |
| 39 | Comparison of Primary Coronary Angioplasty and Intravenous Thrombolytic Therapy for Acute Myocardial Infarction | JAMA - Journal of the American Medical Association | 1997 | 796 |
| 40 | Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats | Journal of Cerebral Blood Flow and Metabolism | 2013 | 782 |
| 41 | Adult Chronic Rhinosinusitis: Definitions, Diagnosis, Epidemiology, and Pathophysiology | Otolaryngology - Head and Neck Surgery | 2003 | 757 |
| 42 | Coronary Perfusion Pressure and the Return of Spontaneous Circulation in Human Cardiopulmonary Resuscitation | JAMA - Journal of the American Medical Association | 1990 | 756 |
| 43 | Inappropriate Implantable Cardioverter-Defibrillator Shocks in MADIT II | Journal of the American College of Cardiology | 2008 | 735 |
| 44 | Ledipasvir and Sofosbuvir Plus Ribavirin for Treatment of HCV Infection in Patients With Advanced Liver Disease | Gastroenterology | 2015 | 725 |
| 45 | Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats | Stroke | 2004 | 719 |
| 46 | Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma | Science | 2012 | 716 |
| 47 | Response assessment criteria for brain metastases: proposal from the RANO group | Lancet Oncology, The | 2015 | 711 |
| 48 | Systematic Literature Review of Imaging Features of Spinal Degeneration in Asymptomatic Populations | American Journal of Neuroradiology | 2015 | 707 |
| 49 | Thrombin-Receptor Antagonist Vorapaxar in Acute Coronary Syndromes | New England Journal of Medicine | 2012 | 701 |
| 50 | Relationship Between Concussion and Neuropsychological Performance in College Football Players | JAMA - Journal of the American Medical Association | 1999 | 700 |
