| # | Title | Journal | Year | Citations |
|---|
| 1 | Biomaterial developments for bone tissue engineering | Biomaterials | 2000 | 1,440 |
| 2 | Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trial | Lancet Oncology, The | 2016 | 1,091 |
| 3 | Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia | Nature | 2011 | 1,016 |
| 4 | Prevention of Contrast-Induced Nephropathy With Sodium Bicarbonate | JAMA - Journal of the American Medical Association | 2004 | 994 |
| 5 | Lactate Clearance vs Central Venous Oxygen Saturation as Goals of Early Sepsis Therapy<subtitle>A Randomized Clinical Trial</subtitle> | JAMA - Journal of the American Medical Association | 2010 | 867 |
| 6 | A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus | Nature Genetics | 2013 | 843 |
| 7 | An Analysis of Outcomes of Reconstruction or Amputation after Leg-Threatening Injuries | New England Journal of Medicine | 2002 | 818 |
| 8 | Effect of Body Mass Index on Outcomes After Cardiac Surgery: Is There an Obesity Paradox? | Annals of Thoracic Surgery | 2011 | 721 |
| 9 | Laparoscopic Repair of Ventral Hernias | Annals of Surgery | 2003 | 720 |
| 10 | Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis | Cancer | 2004 | 691 |
| 11 | The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation* | Critical Care Medicine | 2009 | 659 |
| 12 | Randomized Comparison of Percutaneous Repair and Surgery for Mitral Regurgitation | Journal of the American College of Cardiology | 2015 | 658 |
| 13 | Grazoprevir plus elbasvir in treatment-naive and treatment-experienced patients with hepatitis C virus genotype 1 infection and stage 4–5 chronic kidney disease (the C-SURFER study): a combination phase 3 study | Lancet, The | 2015 | 625 |
| 14 | Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases | Histopathology | 2002 | 576 |
| 15 | Self-administered Topical 5% Imiquimod Cream for External Anogenital Warts | Archives of Dermatology | 1998 | 542 |
| 16 | A Simplified and Structured Teaching Tool for the Evaluation and Management of Pulseless Electrical Activity | Medical Principles and Practice | 2014 | 538 |
| 17 | ICU Admission, Discharge, and Triage Guidelines: A Framework to Enhance Clinical Operations, Development of Institutional Policies, and Further Research | Critical Care Medicine | 2016 | 450 |
| 18 | The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline | Journal of Neuro-Oncology | 2010 | 446 |
| 19 | Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome | Nature Genetics | 2013 | 427 |
| 20 | Incidence of infective endocarditis in England, 2000–13: a secular trend, interrupted time-series analysis | Lancet, The | 2015 | 427 |
| 21 | TNM residual tumor classification revisited | Cancer | 2002 | 423 |
| 22 | Laparoscopic ventral and incisional hernia repair in 407 patients11No competing interests declared. | Journal of the American College of Surgeons | 2000 | 403 |
| 23 | Guidelines for surgical treatment of gastroesophageal reflux disease | Surgical Endoscopy and Other Interventional Techniques | 2010 | 400 |
| 24 | Emergency Department Sonographic Measurement of Optic Nerve Sheath Diameter to Detect Findings of Increased Intracranial Pressure in Adult Head Injury Patients | Annals of Emergency Medicine | 2007 | 395 |
| 25 | Percutaneous Mitral Valve Repair for Mitral Regurgitation in High-Risk Patients | Journal of the American College of Cardiology | 2014 | 390 |
| 26 | Analysis of Aging and Degeneration of the Human Intervertebral Disc | Spine | 1998 | 374 |
| 27 | The Staging of Colorectal Cancer: 2004 and Beyond | Ca-A Cancer Journal for Clinicians | 2004 | 371 |
| 28 | Guidelines for the Use of Retrievable and Convertible Vena Cava Filters: Report from the Society of Interventional Radiology Multidisciplinary Consensus Conference | Journal of Vascular and Interventional Radiology | 2006 | 362 |
| 29 | The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline | Journal of Neuro-Oncology | 2010 | 361 |
| 30 | Efficacy of systemic morpholino exon‐skipping in duchenne dystrophy dogs | Annals of Neurology | 2009 | 356 |
| 31 | A Prospective Evaluation of the Clinical Utility of the Lower-Extremity Injury-Severity Scores | Journal of Bone and Joint Surgery - Series A | 2001 | 352 |
| 32 | Long-term Outcomes of Laparoscopic Resection of Gastric Gastrointestinal Stromal Tumors | Annals of Surgery | 2006 | 347 |
| 33 | Prospective multicenter evaluation of the pulmonary embolism rule‐out criteria | Journal of Thrombosis and Haemostasis | 2008 | 345 |
| 34 | Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics | 2007 | 343 |
| 35 | A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life | Supportive Care in Cancer | 2010 | 338 |
| 36 | Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol* | Critical Care Medicine | 2011 | 317 |
| 37 | Clinical Use of Fluorodeoxyglucose F 18 Positron Emission Tomography for Detection of Renal Cell Carcinoma | Journal of Urology | 2004 | 315 |
| 38 | Age-related changes in osteogenic stem cells in mice | Journal of Bone and Mineral Research | 1996 | 306 |
| 39 | Lack of Effect of Lovastatin on Restenosis after Coronary Angioplasty | New England Journal of Medicine | 1994 | 290 |
| 40 | Human Intervertebral Disc Cells from the Annulus: Three-Dimensional Culture in Agarose or Alginate and Responsiveness to TGF-β1 | Experimental Cell Research | 1997 | 286 |
| 41 | Efficacy and safety of grazoprevir (MK-5172) and elbasvir (MK-8742) in patients with hepatitis C virus and HIV co-infection (C-EDGE CO-INFECTION): a non-randomised, open-label trial | Lancet HIV,the | 2015 | 285 |
| 42 | The role of steroids in the management of brain metastases: a systematic review and evidence-based clinical practice guideline | Journal of Neuro-Oncology | 2010 | 283 |
| 43 | The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline | Journal of Neuro-Oncology | 2010 | 277 |
| 44 | Poland’s syndrome revisited | Annals of Thoracic Surgery | 2002 | 267 |
| 45 | Maternal Selective Serotonin Reuptake Inhibitor Use During Pregnancy and Newborn Neurobehavior | Pediatrics | 2004 | 264 |
| 46 | Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity | Nature Genetics | 1994 | 263 |
| 47 | Higher Mental Workload is Associated With Poorer Laparoscopic Performance as Measured by the NASA-TLX Tool | Simulation in Healthcare | 2010 | 252 |
| 48 | Initial results with an electrothermal bipolar vessel sealer | Surgical Endoscopy and Other Interventional Techniques | 2001 | 250 |
| 49 | Guidelines for Perioperative Care for Pancreatoduodenectomy: Enhanced Recovery After Surgery (ERAS) Recommendations 2019 | World Journal of Surgery | 2020 | 249 |
| 50 | Rotenone Model of Parkinson Disease | Journal of Biological Chemistry | 2005 | 244 |
