| # | Title | Journal | Year | Citations |
|---|
| 1 | limma powers differential expression analyses for RNA-sequencing and microarray studies | Nucleic Acids Research | 2015 | 26,032 |
| 2 | Gene ontology analysis for RNA-seq: accounting for selection bias | Genome Biology | 2010 | 5,824 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 4 | The Bcl-2 Protein Family: Arbiters of Cell Survival | Science | 1998 | 4,650 |
| 5 | Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation | Nucleic Acids Research | 2012 | 4,474 |
| 6 | Rapid colorimetric assay for cell growth and survival | Journal of Immunological Methods | 1986 | 4,360 |
| 7 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 8 | The BCL-2 protein family: opposing activities that mediate cell death | Nature Reviews Molecular Cell Biology | 2008 | 3,898 |
| 9 | The Bcl2 family: regulators of the cellular life-or-death switch | Nature Reviews Cancer | 2002 | 3,457 |
| 10 | Cancer stem cells in solid tumours: accumulating evidence and unresolved questions | Nature Reviews Cancer | 2008 | 3,070 |
| 11 | Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells | Nature | 1988 | 3,029 |
| 12 | New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry | 2010 | 2,982 |
| 13 | T cell receptor antagonist peptides induce positive selection | Cell | 1994 | 2,538 |
| 14 | Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy | Nature Reviews Molecular Cell Biology | 2014 | 2,444 |
| 15 | ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets | Nature Medicine | 2013 | 2,426 |
| 16 | The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote | Nucleic Acids Research | 2013 | 2,389 |
| 17 | Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins | Cell | 2000 | 2,191 |
| 18 | Nomenclature of monocytes and dendritic cells in blood | Blood | 2010 | 2,046 |
| 19 | Mouse and human dendritic cell subtypes | Nature Reviews Immunology | 2002 | 2,008 |
| 20 | A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases | Nature Medicine | 2015 | 1,967 |
| 21 | Help for cytotoxic-T-cell responses is mediated by CD40 signalling | Nature | 1998 | 1,907 |
| 22 | Detection and localization of surgically resectable cancers with a multi-analyte blood test | Science | 2018 | 1,872 |
| 23 | Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells | Nature | 1988 | 1,871 |
| 24 | The Bcl-2 apoptotic switch in cancer development and therapy | Oncogene | 2007 | 1,847 |
| 25 | Generation of a functional mammary gland from a single stem cell | Nature | 2006 | 1,824 |
| 26 | IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy | Nature Genetics | 2009 | 1,808 |
| 27 | The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads | Nucleic Acids Research | 2019 | 1,744 |
| 28 | ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays | Journal of Immunological Methods | 2009 | 1,642 |
| 29 | Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function | Molecular Cell | 2005 | 1,639 |
| 30 | Normalization of cDNA microarray data | Methods | 2003 | 1,617 |
| 31 | Opportunities and challenges in long-read sequencing data analysis | Genome Biology | 2020 | 1,536 |
| 32 | Cell Death in Development | Cell | 1999 | 1,434 |
| 33 | An enzymic method for the trace iodination of immunoglobulins and other proteins | Biochemical Journal | 1969 | 1,415 |
| 34 | Apoptosis Signaling | Annual Review of Biochemistry | 2000 | 1,404 |
| 35 | Purification and unique properties of mammary epithelial stem cells | Nature | 2006 | 1,404 |
| 36 | Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity | Science | 1999 | 1,386 |
| 37 | Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements | Immunology and Cell Biology | 1998 | 1,349 |
| 38 | The Bcl-2 family: roles in cell survival and oncogenesis | Oncogene | 2003 | 1,342 |
| 39 | Cells of origin in cancer | Nature | 2011 | 1,266 |
| 40 | Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers | Nature Medicine | 2009 | 1,261 |
| 41 | ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim | Cell | 2007 | 1,235 |
| 42 | p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa | Science | 2003 | 1,187 |
| 43 | The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized | Cancer Cell | 2006 | 1,149 |
| 44 | Foxp3+ follicular regulatory T cells control the germinal center response | Nature Medicine | 2011 | 1,092 |
| 45 | Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins | Genes and Development | 2005 | 1,071 |
| 46 | Steady-state and inflammatory dendritic-cell development | Nature Reviews Immunology | 2007 | 1,036 |
| 47 | Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer | Science Translational Medicine | 2016 | 1,036 |
| 48 | Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak | Science | 2007 | 1,021 |
| 49 | Bim: a novel member of the Bcl-2 family that promotes apoptosis | EMBO Journal | 1998 | 1,005 |
| 50 | The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex | Molecular Cell | 1999 | 964 |
