| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study | Lancet Oncology, The | 2011 | 3,758 |
| 3 | Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis | Cell Research | 2015 | 1,777 |
| 4 | Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs | Nature Communications | 2016 | 1,729 |
| 5 | Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy | Cell | 2017 | 1,377 |
| 6 | Modulatory Effects of 1,25-Dihydroxyvitamin D3 on Human B Cell Differentiation | Journal of Immunology | 2007 | 936 |
| 7 | Mesenchymal stem cells: a new trend for cell therapy | Acta Pharmacologica Sinica | 2013 | 758 |
| 8 | Global Vascular Guidelines on the Management of Chronic Limb-Threatening Ischemia | European Journal of Vascular and Endovascular Surgery | 2019 | 741 |
| 9 | Recurrence of endometriosis and its control | Human Reproduction Update | 2009 | 538 |
| 10 | Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome | Nature Genetics | 2012 | 505 |
| 11 | Second Asia–Pacific Consensus Guidelines for Helicobacter pylori infection | Journal of Gastroenterology and Hepatology (Australia) | 2009 | 493 |
| 12 | Effect of Laparoscopic vs Open Distal Gastrectomy on 3-Year Disease-Free Survival in Patients With Locally Advanced Gastric Cancer | JAMA - Journal of the American Medical Association | 2019 | 477 |
| 13 | Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes | Cell Stem Cell | 2014 | 459 |
| 14 | miR-21 plays a pivotal role in gastric cancer pathogenesis and progression | Laboratory Investigation | 2008 | 434 |
| 15 | STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4 | Molecular Cancer | 2017 | 434 |
| 16 | Final overall survival results from a randomised, phase III study of erlotinib versus chemotherapy as first-line treatment of EGFR mutation-positive advanced non-small-cell lung cancer (OPTIMAL, CTONG-0802) | Annals of Oncology | 2015 | 406 |
| 17 | Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma | Cancer Biomarkers | 2016 | 402 |
| 18 | The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α | Nature Medicine | 2012 | 397 |
| 19 | METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer | Molecular Cancer | 2019 | 389 |
| 20 | Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 367 |
| 21 | PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation | Redox Biology | 2019 | 356 |
| 22 | Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium | International Journal of Cardiology | 2015 | 350 |
| 23 | Complex silica composite nanomaterials templated with DNA origami | Nature | 2018 | 346 |
| 24 | Incidence and Etiology of Drug-Induced Liver Injury in Mainland China | Gastroenterology | 2019 | 346 |
| 25 | Vascularized 3D printed scaffolds for promoting bone regeneration | Biomaterials | 2019 | 345 |
| 26 | The trans-ancestral genomic architecture of glycemic traits | Nature Genetics | 2021 | 341 |
| 27 | Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study | Lancet Oncology, The | 2012 | 337 |
| 28 | Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy | Gut | 2018 | 330 |
| 29 | A Report Card to Grade Helicobacter pylori Therapy | Helicobacter | 2007 | 327 |
| 30 | Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 324 |
| 31 | Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock | Cell Research | 2013 | 324 |
| 32 | Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition | Molecular BioSystems | 2012 | 322 |
| 33 | Effect of Probiotics on Inducing Remission and Maintaining Therapy in Ulcerative Colitis, Crohnʼs Disease, and Pouchitis | Inflammatory Bowel Diseases | 2014 | 320 |
| 34 | Lactate dehydrogenase a in cancer: A promising target for diagnosis and therapy | IUBMB Life | 2013 | 317 |
| 35 | Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma | Nature Genetics | 2015 | 315 |
| 36 | IL-22+CD4+ T Cells Promote Colorectal Cancer Stemness via STAT3 Transcription Factor Activation and Induction of the Methyltransferase DOT1L | Immunity | 2014 | 309 |
| 37 | Increased prevalence of T helper 17 (Th17) cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion patients | Journal of Reproductive Immunology | 2010 | 307 |
| 38 | Fifth Chinese National Consensus Report on the management of Helicobacter pylori infection | Helicobacter | 2018 | 304 |
| 39 | Rheumatic Diseases in China | Arthritis Research and Therapy | 2008 | 302 |
| 40 | DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury | Nature Biomedical Engineering | 2018 | 297 |
| 41 | Discovery of Aptamers Targeting the Receptor-Binding Domain of the SARS-CoV-2 Spike Glycoprotein | Analytical Chemistry | 2020 | 296 |
| 42 | Aptamer-Based Detection of Circulating Targets for Precision Medicine | Chemical Reviews | 2021 | 294 |
| 43 | A management algorithm for patients with intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC) | Intensive Care Medicine | 2019 | 292 |
| 44 | Exosomal miR-196a derived from cancer-associated fibroblasts confers cisplatin resistance in head and neck cancer through targeting CDKN1B and ING5 | Genome Biology | 2019 | 291 |
| 45 | Downregulated MEG3 activates autophagy and increases cell proliferation in bladder cancer | Molecular BioSystems | 2013 | 289 |
| 46 | Multicomponent Plasmonic Nanoparticles: From Heterostructured Nanoparticles to Colloidal Composite Nanostructures | Chemical Reviews | 2019 | 289 |
| 47 | circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity | Nature Communications | 2021 | 287 |
| 48 | Identification of type 2 diabetes loci in 433,540 East Asian individuals | Nature | 2020 | 282 |
| 49 | Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours | Nature Biomedical Engineering | 2019 | 279 |
| 50 | Efficacy of Standard Trauma Craniectomy for Refractory Intracranial Hypertension with Severe Traumatic Brain Injury: A Multicenter, Prospective, Randomized Controlled Study | Journal of Neurotrauma | 2005 | 275 |
