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Top Articles

#TitleJournalYearCitations
1A new method of classifying prognostic comorbidity in longitudinal studies: Development and validationJournal of Chronic Diseases198740,131
2The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemiaBlood20167,429
3Combined Nivolumab and Ipilimumab or Monotherapy in Untreated MelanomaNew England Journal of Medicine20156,773
4The 2016 revision of the World Health Organization classification of lymphoid neoplasmsBlood20165,965
5Validation of a combined comorbidity indexJournal of Clinical Epidemiology19945,389
6Mitochondrial dysfunction and oxidative stress in neurodegenerative diseasesNature20065,213
7deepTools2: a next generation web server for deep-sequencing data analysisNucleic Acids Research20165,157
8Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Autophagy20164,701
9Nitric oxide as a secretory product of mammalian cellsFASEB Journal19924,161
10Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridineAnalytical Biochemistry19804,155
11Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018Cell Death and Differentiation20184,036
12Increased Survival with Enzalutamide in Prostate Cancer after ChemotherapyNew England Journal of Medicine20123,847
13NITRIC OXIDE AND MACROPHAGE FUNCTIONAnnual Review of Immunology19973,707
14MUTANTS OF ESCHERICHIA COLI REQUIRING METHIONINE OR VITAMIN B 12Journal of Bacteriology19503,476
15EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 updateAnnals of the Rheumatic Diseases20173,366
16The landscape of somatic copy-number alteration across human cancersNature20103,331
17THE COLORIMETRIC DETERMINATION OF LACTIC ACID IN BIOLOGICAL MATERIALJournal of Biological Chemistry19413,200
18Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop CodonsCell20123,152
19Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through METNature Medicine20123,098
20Immune-Related Adverse Events Associated with Immune Checkpoint BlockadeNew England Journal of Medicine20183,047
21Testing the Efficiency and Independence of Attentional NetworksJournal of Cognitive Neuroscience20022,940
22VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic nicheNature20052,841
23Nitric oxide synthases: Roles, tolls, and controlsCell19942,815
24The NimStim set of facial expressions: Judgments from untrained research participantsPsychiatry Research20092,767
25Temporal profile of neuronal damage in a model of transient forebrain ischemiaAnnals of Neurology19822,709
26Integrative Clinical Genomics of Advanced Prostate CancerCell20152,660
27International evidence-based recommendations for point-of-care lung ultrasoundIntensive Care Medicine20122,641
28Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidanceHepatology20182,620
29Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemiaNature19872,558
30Neutrophils and immunity: challenges and opportunitiesNature Reviews Immunology20062,394
31Efficacy of Gefitinib, an Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase, in Symptomatic Patients With Non–Small Cell Lung CancerJAMA - Journal of the American Medical Association20032,360
32Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trialLancet Oncology, The20152,353
33Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic DifferentiationCancer Cell20102,328
34Cornell scale for depression in dementiaBiological Psychiatry19882,322
35A MICROCOLORIMETRIC METHOD FOR THE DETERMINATION OF INORGANIC PHOSPHORUSJournal of Biological Chemistry19532,289
36Points of control in inflammationNature20022,262
37Immune Checkpoint Blockade in Cancer TherapyJournal of Clinical Oncology20152,220
38Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditionsNeuroscience19912,214
39Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.Journal of Immunology19882,193
40The metabotropic glutamate receptors: Structure and functionsNeuropharmacology19952,138
41Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working groupBlood20092,128
42Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR-Mutant Lung CancersClinical Cancer Research20132,097
43Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursorsBlood20002,090
44Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent productionJournal of Immunology19882,079
45Breast cancer statistics, 2019Ca-A Cancer Journal for Clinicians20192,068
46Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trialsLancet, The20102,064
47Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liverNature Cell Biology20152,064
48Osteoarthritis: A disease of the joint as an organArthritis and Rheumatism20122,055
49Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic FactorCell20132,013
50The immunology of stroke: from mechanisms to translationNature Medicine20112,006