| # | Title | Journal | Year | Citations |
|---|
| 1 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 2 | Neurogenesis in the adult human hippocampus | Nature Medicine | 1998 | 5,606 |
| 3 | Treatment of Deep Cartilage Defects in the Knee with Autologous Chondrocyte Transplantation | New England Journal of Medicine | 1994 | 5,173 |
| 4 | Effects of Bariatric Surgery on Mortality in Swedish Obese Subjects | New England Journal of Medicine | 2007 | 4,094 |
| 5 | Mild cognitive impairment - beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment | Journal of Internal Medicine | 2004 | 4,039 |
| 6 | Lifestyle, Diabetes, and Cardiovascular Risk Factors 10 Years after Bariatric Surgery | New England Journal of Medicine | 2004 | 4,023 |
| 7 | Definition and classification of cancer cachexia: an international consensus | Lancet Oncology, The | 2011 | 4,015 |
| 8 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 9 | Functional interactions between the gut microbiota and host metabolism | Nature | 2012 | 3,582 |
| 10 | The gut microbiota — masters of host development and physiology | Nature Reviews Microbiology | 2013 | 2,711 |
| 11 | Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria | Lancet Neurology, The | 2014 | 2,657 |
| 12 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 13 | Premature ageing in mice expressing defective mitochondrial DNA polymerase | Nature | 2004 | 2,318 |
| 14 | Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel | European Heart Journal | 2017 | 2,292 |
| 15 | Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study | Lancet, The | 2010 | 2,119 |
| 16 | Bioelectrical impedance analysis?part I: review of principles and methods | Clinical Nutrition | 2004 | 2,089 |
| 17 | Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005) | European Heart Journal | 2005 | 1,986 |
| 18 | Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification | Gut | 1999 | 1,959 |
| 19 | Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial | Lancet, The | 1999 | 1,938 |
| 20 | Standardization of sample collection, isolation and analysis methods in extracellular vesicle research | Journal of Extracellular Vesicles | 2013 | 1,837 |
| 21 | Morbidity and mortality in the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension) | Lancet, The | 1991 | 1,829 |
| 22 | Definition of major bleeding in clinical investigations of antihemostatic medicinal products in surgical patients | Journal of Thrombosis and Haemostasis | 2010 | 1,826 |
| 23 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 24 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,789 |
| 25 | XENical in the Prevention of Diabetes in Obese Subjects (XENDOS) Study: A randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients | Diabetes Care | 2004 | 1,673 |
| 26 | Bioelectrical impedance analysis—part II: utilization in clinical practice | Clinical Nutrition | 2004 | 1,643 |
| 27 | Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease | New England Journal of Medicine | 2014 | 1,613 |
| 28 | Diet–microbiota interactions as moderators of human metabolism | Nature | 2016 | 1,602 |
| 29 | 15-year longitudinal study of blood pressure and dementia | Lancet, The | 1996 | 1,579 |
| 30 | Intrauterine growth curves based on ultrasonically estimated foetal weights | Acta Paediatrica, International Journal of Paediatrics | 1996 | 1,555 |
| 31 | Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study | Lancet Neurology, The | 2006 | 1,494 |
| 32 | Gastroenteropancreatic neuroendocrine tumours | Lancet Oncology, The | 2008 | 1,474 |
| 33 | The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease | Cell Host and Microbe | 2018 | 1,441 |
| 34 | How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study | BJU International | 2001 | 1,429 |
| 35 | Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice | Neuron | 2001 | 1,419 |
| 36 | Common genetic determinants of vitamin D insufficiency: a genome-wide association study | Lancet, The | 2010 | 1,385 |
| 37 | Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice | Nature Genetics | 1998 | 1,377 |
| 38 | Premature mortality due to cardiovascular disease in hypopituitarism | Lancet, The | 1990 | 1,370 |
| 39 | Randomised trial of old and new antihypertensive drugs in elderly patients: cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 study | Lancet, The | 1999 | 1,367 |
| 40 | Consensus definition of sarcopenia, cachexia and pre-cachexia: Joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics” | Clinical Nutrition | 2010 | 1,360 |
| 41 | Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial | Lancet Oncology, The | 2013 | 1,358 |
| 42 | The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting | Human Reproduction | 2011 | 1,339 |
| 43 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,328 |
| 44 | Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria | Alzheimer's and Dementia | 2016 | 1,318 |
| 45 | Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study | Lancet, The | 2015 | 1,295 |
| 46 | Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans | Nature Genetics | 2008 | 1,286 |
| 47 | Two- to 9-Year Outcome After Autologous Chondrocyte Transplantation of the Knee | Clinical Orthopaedics and Related Research | 2000 | 1,280 |
| 48 | The Study on Cognition and Prognosis in the Elderly (SCOPE) | Journal of Hypertension | 2003 | 1,251 |
| 49 | Global, regional, and national levels and causes of maternal mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2014 | 1,230 |
| 50 | The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms | Leukemia | 2022 | 1,211 |
