| # | Title | Journal | Year | Citations |
|---|
| 1 | New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1) | European Journal of Cancer | 2009 | 21,739 |
| 2 | The FAIR Guiding Principles for scientific data management and stewardship | Scientific Data | 2016 | 8,670 |
| 3 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 4 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 6,376 |
| 5 | Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L) | Quality of Life Research | 2011 | 5,877 |
| 6 | Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR | Eurosurveillance | 2020 | 5,865 |
| 7 | Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia | New England Journal of Medicine | 2012 | 4,688 |
| 8 | Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012 | European Journal of Cancer | 2013 | 4,448 |
| 9 | Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel | Blood | 2017 | 4,375 |
| 10 | Preoperative Chemoradiotherapy for Esophageal or Junctional Cancer | New England Journal of Medicine | 2012 | 4,296 |
| 11 | Mild cognitive impairment - beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment | Journal of Internal Medicine | 2004 | 4,039 |
| 12 | Incidence of thrombotic complications in critically ill ICU patients with COVID-19 | Thrombosis Research | 2020 | 3,872 |
| 13 | Allergic Rhinitis and its Impact on Asthma (ARIA) 2008* | Allergy: European Journal of Allergy and Clinical Immunology | 2008 | 3,827 |
| 14 | Percutaneous Coronary Intervention versus Coronary-Artery Bypass Grafting for Severe Coronary Artery Disease | New England Journal of Medicine | 2009 | 3,634 |
| 15 | Screening and Prostate-Cancer Mortality in a Randomized European Study | New England Journal of Medicine | 2009 | 3,540 |
| 16 | Global Prevalence and Major Risk Factors of Diabetic Retinopathy | Diabetes Care | 2012 | 3,439 |
| 17 | Assessing the Performance of Prediction Models | Epidemiology | 2010 | 3,387 |
| 18 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update | Annals of the Rheumatic Diseases | 2017 | 3,366 |
| 19 | Biological, clinical and population relevance of 95 loci for blood lipids | Nature | 2010 | 3,249 |
| 20 | The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update | Nucleic Acids Research | 2018 | 3,003 |
| 21 | Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet | Blood | 2010 | 2,963 |
| 22 | Clinical Practice Guidelines for the Diagnosis and Management of Intravascular Catheter-Related Infection: 2009 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases | 2009 | 2,904 |
| 23 | Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936 | Leukemia | 2003 | 2,788 |
| 24 | A clinical approach to diagnosis of autoimmune encephalitis | Lancet Neurology, The | 2016 | 2,782 |
| 25 | Pre-eclampsia | Lancet, The | 2010 | 2,648 |
| 26 | Discovery and refinement of loci associated with lipid levels | Nature Genetics | 2013 | 2,641 |
| 27 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 28 | Spatial partitioning of the regulatory landscape of the X-inactivation centre | Nature | 2012 | 2,595 |
| 29 | EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent | European Urology | 2017 | 2,497 |
| 30 | Socioeconomic Inequalities in Health in 22 European Countries | New England Journal of Medicine | 2008 | 2,464 |
| 31 | A reference panel of 64,976 haplotypes for genotype imputation | Nature Genetics | 2016 | 2,421 |
| 32 | Birth Prevalence of Congenital Heart Disease Worldwide | Journal of the American College of Cardiology | 2011 | 2,400 |
| 33 | Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial | Lancet, The | 2006 | 2,349 |
| 34 | The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma | American Journal of Surgical Pathology | 2005 | 2,334 |
| 35 | Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation | Cancer Cell | 2010 | 2,328 |
| 36 | Management ofHelicobacter pyloriinfection—the Maastricht V/Florence Consensus Report | Gut | 2017 | 2,245 |
| 37 | Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression | Nature Genetics | 2018 | 2,224 |
| 38 | Osteoarthritis | Lancet, The | 2019 | 2,193 |
| 39 | FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0 | European Journal of Nuclear Medicine and Molecular Imaging | 2015 | 2,188 |
| 40 | A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease | Nature Genetics | 2015 | 2,054 |
| 41 | Nomenclature of monocytes and dendritic cells in blood | Blood | 2010 | 2,046 |
| 42 | Silent Brain Infarcts and the Risk of Dementia and Cognitive Decline | New England Journal of Medicine | 2003 | 2,037 |
| 43 | The role of nasal carriage in Staphylococcus aureus infections | Lancet Infectious Diseases, The | 2005 | 2,037 |
| 44 | Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and Postpartum | Thyroid | 2011 | 2,014 |
| 45 | Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers | Statistics in Medicine | 2011 | 1,989 |
| 46 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 47 | Review: A gentle introduction to imputation of missing values | Journal of Clinical Epidemiology | 2006 | 1,900 |
| 48 | Diabetes mellitus and the risk of dementia | Neurology | 1999 | 1,896 |
| 49 | Common Carotid Intima-Media Thickness and Risk of Stroke and Myocardial Infarction | Circulation | 1997 | 1,848 |
| 50 | A newly discovered human pneumovirus isolated from young children with respiratory tract disease | Nature Medicine | 2001 | 1,821 |
