1 | Sorafenib in Advanced Hepatocellular Carcinoma | New England Journal of Medicine | 2008 | 12,786 |
2 | Signatures of mutational processes in human cancer | Nature | 2013 | 8,544 |
3 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 8,062 |
4 | Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease | American Journal of Respiratory and Critical Care Medicine | 2013 | 7,962 |
5 | Management of hepatocellular carcinoma: An update | Hepatology | 2011 | 7,303 |
6 | Management of hepatocellular carcinoma | Hepatology | 2005 | 5,489 |
7 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,847 |
8 | Biological properties of extracellular vesicles and their physiological functions | Journal of Extracellular Vesicles | 2015 | 4,470 |
9 | Hepatocellular carcinoma | Lancet, The | 2018 | 4,416 |
10 | Hepatocellular carcinoma | Lancet, The | 2012 | 3,984 |
11 | Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial | Lancet, The | 2002 | 3,256 |
12 | Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study | Lancet, The | 2013 | 3,047 |
13 | Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet, The | 2017 | 3,005 |
14 | Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival | Hepatology | 2003 | 2,704 |
15 | Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary | American Journal of Respiratory and Critical Care Medicine | 2017 | 2,548 |
16 | Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial | Lancet, The | 2002 | 2,368 |
17 | Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci | Nature Genetics | 2010 | 2,348 |
18 | BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update | Journal of Hepatology | 2022 | 2,325 |
19 | Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study | Lancet Oncology, The | 2010 | 2,236 |
20 | A global survey of potential acceptance of a COVID-19 vaccine | Nature Medicine | 2021 | 2,194 |
21 | Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial | Lancet, The | 2019 | 1,916 |
22 | Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: Resection versus transplantation | Hepatology | 1999 | 1,895 |
23 | 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation | Heart Rhythm | 2017 | 1,869 |
24 | Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study | Lancet, The | 2017 | 1,822 |
25 | Antiphospholipid syndrome: Clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients | Arthritis and Rheumatism | 2002 | 1,818 |
26 | Intra-tumour heterogeneity: a looking glass for cancer? | Nature Reviews Cancer | 2012 | 1,757 |
27 | Rhabdomyolysis and Acute Kidney Injury | New England Journal of Medicine | 2009 | 1,737 |
28 | Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria | Movement Disorders | 2017 | 1,652 |
29 | Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets | Gastroenterology | 2011 | 1,640 |
30 | Simplified criteria for the diagnosis of autoimmune hepatitis | Hepatology | 2008 | 1,635 |
31 | Genes that mediate breast cancer metastasis to the brain | Nature | 2009 | 1,630 |
32 | Effect of Intravenous Albumin on Renal Impairment and Mortality in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis | New England Journal of Medicine | 1999 | 1,553 |
33 | Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target | American Journal of Gastroenterology | 2015 | 1,532 |
34 | Liver cirrhosis | Lancet, The | 2014 | 1,528 |
35 | Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria | Alzheimer's and Dementia | 2016 | 1,491 |
36 | Cholangiocarcinoma 2020: the next horizon in mechanisms and management | Nature Reviews Gastroenterology and Hepatology | 2020 | 1,461 |
37 | Recommended diagnostic criteria for paraneoplastic neurological syndromes | Journal of Neurology, Neurosurgery and Psychiatry | 2004 | 1,442 |
38 | Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis | Hepatology | 1996 | 1,437 |
39 | 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus | Arthritis and Rheumatology | 2019 | 1,401 |
40 | Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia | Nature | 2011 | 1,390 |
41 | T-cell invigoration to tumour burden ratio associated with anti-PD-1 response | Nature | 2017 | 1,390 |
42 | Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: the GOLD science committee report 2019 | European Respiratory Journal | 2019 | 1,383 |
43 | Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines—2016 revision | Journal of Allergy and Clinical Immunology | 2017 | 1,379 |
44 | A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus | Arthritis and Rheumatism | 2011 | 1,374 |
45 | Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo | Nature Immunology | 2009 | 1,288 |
46 | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 | Nature Genetics | 2011 | 1,235 |
47 | New insights into the genetic etiology of Alzheimer’s disease and related dementias | Nature Genetics | 2022 | 1,217 |
48 | ZAP-70 Expression as a Surrogate for Immunoglobulin-Variable-Region Mutations in Chronic Lymphocytic Leukemia | New England Journal of Medicine | 2003 | 1,205 |
49 | Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias | PLoS ONE | 2008 | 1,191 |
50 | ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications | Journal of Crohn's and Colitis | 2019 | 1,190 |