| # | Title | Journal | Year | Citations |
|---|
| 1 | The neighbor-joining method: a new method for reconstructing phylogenetic trees. | Molecular Biology and Evolution | 1987 | 49,040 |
| 2 | The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments | Clinical Chemistry | 2009 | 12,487 |
| 3 | The american college of rheumatology 1990 criteria for the classification of fibromyalgia | Arthritis and Rheumatism | 1990 | 7,828 |
| 4 | Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease | American Journal of Respiratory and Critical Care Medicine | 2013 | 7,792 |
| 5 | International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) | Journal of Thrombosis and Haemostasis | 2006 | 6,039 |
| 6 | A receptor-mediated pathway for cholesterol homeostasis | Science | 1986 | 5,240 |
| 7 | Correspondence of the brain's functional architecture during activation and rest | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 4,636 |
| 8 | Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease | Cell | 2017 | 4,081 |
| 9 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 10 | Meta-analysis: Antithrombotic Therapy to Prevent Stroke in Patients Who Have Nonvalvular Atrial Fibrillation | Annals of Internal Medicine | 2007 | 3,980 |
| 11 | Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus | Arthritis and Rheumatism | 2012 | 3,838 |
| 12 | Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease | Diabetes Care | 1991 | 3,723 |
| 13 | Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration | PLoS Medicine | 2007 | 3,710 |
| 14 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 15 | Identifying Medical Diagnoses and Treatable Diseases by Image-Based Deep Learning | Cell | 2018 | 2,822 |
| 16 | Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease | Nature Genetics | 2008 | 2,764 |
| 17 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 18 | International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: Report of an International workshop | Arthritis and Rheumatism | 1999 | 2,512 |
| 19 | Metastasis to bone: causes, consequences and therapeutic opportunities | Nature Reviews Cancer | 2002 | 2,498 |
| 20 | Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases | 2016 | 2,489 |
| 21 | The Influence of Finasteride on the Development of Prostate Cancer | New England Journal of Medicine | 2003 | 2,434 |
| 22 | Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary | American Journal of Respiratory and Critical Care Medicine | 2017 | 2,393 |
| 23 | A multigenic program mediating breast cancer metastasis to bone | Cancer Cell | 2003 | 2,325 |
| 24 | Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States | Arthritis and Rheumatism | 1998 | 2,294 |
| 25 | From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus | Diabetes | 2009 | 2,251 |
| 26 | Cellular defenses against damage from reactive oxygen species | Physiological Reviews | 1994 | 2,089 |
| 27 | The pandemic of physical inactivity: global action for public health | Lancet, The | 2012 | 2,054 |
| 28 | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk | Nature Genetics | 2010 | 1,982 |
| 29 | Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions* | Endocrine Reviews | 1991 | 1,977 |
| 30 | Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials | Lancet, The | 2014 | 1,971 |
| 31 | The Human Brainnetome Atlas: A New Brain Atlas Based on Connectional Architecture | Cerebral Cortex | 2016 | 1,962 |
| 32 | Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection | Nature | 1988 | 1,912 |
| 33 | Pathogenesis of NIDDM: A Balanced Overview | Diabetes Care | 1992 | 1,903 |
| 34 | Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma | JAMA - Journal of the American Medical Association | 2015 | 1,874 |
| 35 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,789 |
| 36 | Bone Morphogenetic Proteins | Growth Factors | 2004 | 1,787 |
| 37 | Regulation of antioxidant enzymes: a significant role for melatonin | Journal of Pineal Research | 2004 | 1,713 |
| 38 | Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells | Circulation | 2000 | 1,711 |
| 39 | 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative | Annals of the Rheumatic Diseases | 2013 | 1,705 |
| 40 | Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration | International Journal of Surgery | 2014 | 1,698 |
| 41 | Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease | Nature Genetics | 2011 | 1,685 |
| 42 | Secukinumab in Plaque Psoriasis — Results of Two Phase 3 Trials | New England Journal of Medicine | 2014 | 1,675 |
| 43 | Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis | Nature Genetics | 2010 | 1,631 |
| 44 | Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection | New England Journal of Medicine | 2013 | 1,605 |
| 45 | Stimulation of Bone Formation in Vitro and in Rodents by Statins | Science | 1999 | 1,600 |
| 46 | A Common Allele on Chromosome 9 Associated with Coronary Heart Disease | Science | 2007 | 1,591 |
| 47 | European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection | Public Health Nutrition | 2002 | 1,539 |
| 48 | The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs | Aging Cell | 2015 | 1,534 |
| 49 | Increased bone formation in osteocalcin-deficient mice | Nature | 1996 | 1,522 |
| 50 | Elastic Moduli of Breast and Prostate Tissues under Compression | Ultrasonic Imaging | 1998 | 1,513 |
