| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Fiji: an open-source platform for biological-image analysis | Nature Methods | 2012 | 51,625 |
| 2 | Image Quality Assessment: From Error Visibility to Structural Similarity | IEEE Transactions on Image Processing | 2004 | 37,389 |
| 3 | QIIME allows analysis of high-throughput community sequencing data | Nature Methods | 2010 | 32,880 |
| 4 | MicroRNAs: Target Recognition and Regulatory Functions | Cell | 2009 | 18,170 |
| 5 | Full-length transcriptome assembly from RNA-Seq data without a reference genome | Nature Biotechnology | 2011 | 18,090 |
| 6 | Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination | Acta Crystallographica Section D: Biological Crystallography | 1998 | 14,783 |
| 7 | Cluster analysis and display of genome-wide expression patterns | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 14,567 |
| 8 | Molecular portraits of human breast tumours | Nature | 2000 | 13,655 |
| 9 | A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity | Science | 2012 | 13,436 |
| 10 | A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity | Science | 2012 | 13,436 |
| 11 | U1 snRNP regulates cancer cell migration and invasion in vitro | Nature Communications | 2020 | 13,413 |
| 12 | Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 | Nature Biotechnology | 2019 | 12,956 |
| 13 | Positional cloning of the mouse obese gene and its human homologue | Nature | 1994 | 12,326 |
| 14 | Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death | Cell | 2012 | 10,267 |
| 15 | Integrins: Versatility, modulation, and signaling in cell adhesion | Cell | 1992 | 9,885 |
| 16 | Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 9,851 |
| 17 | Prospective identification of tumorigenic breast cancer cells | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 9,422 |
| 18 | Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling | Nature | 2000 | 9,069 |
| 19 | MicroRNA expression profiles classify human cancers | Nature | 2005 | 9,031 |
| 20 | Stem cells, cancer, and cancer stem cells | Nature | 2001 | 8,773 |
| 21 | Targeted gene expression as a means of altering cell fates and generating dominant phenotypes | Development (Cambridge) | 1993 | 8,450 |
| 22 | Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences | Nature Biotechnology | 2013 | 8,414 |
| 23 | PD-1 Blockade in Tumors with Mismatch-Repair Deficiency | New England Journal of Medicine | 2015 | 7,962 |
| 24 | An Information-Maximization Approach to Blind Separation and Blind Deconvolution | Neural Computation | 1995 | 7,920 |
| 25 | Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 7,834 |
| 26 | Imaging Intracellular Fluorescent Proteins at Nanometer Resolution | Science | 2006 | 7,786 |
| 27 | The Pfam protein families database | Nucleic Acids Research | 2007 | 7,778 |
| 28 | Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms | ISME Journal | 2012 | 7,737 |
| 29 | Finding the missing heritability of complex diseases | Nature | 2009 | 7,627 |
| 30 | The Genotype-Tissue Expression (GTEx) project | Nature Genetics | 2013 | 7,253 |
| 31 | Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM) | Nature Methods | 2006 | 7,035 |
| 32 | Innate Immune Recognition | Annual Review of Immunology | 2002 | 6,978 |
| 33 | The organization of the human cerebral cortex estimated by intrinsic functional connectivity | Journal of Neurophysiology | 2011 | 6,920 |
| 34 | Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene | Science | 1998 | 6,832 |
| 35 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells | Nature Immunology | 2003 | 6,769 |
| 36 | The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity | Nature | 2012 | 6,763 |
| 37 | MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy | Nature Methods | 2017 | 6,715 |
| 38 | Cancer Genome Landscapes | Science | 2013 | 6,694 |
| 39 | Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade | Cell | 1997 | 6,686 |
| 40 | The nuclear receptor superfamily: The second decade | Cell | 1995 | 6,527 |
| 41 | Human gut microbiome viewed across age and geography | Nature | 2012 | 6,465 |
| 42 | Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis | Nature | 1993 | 6,432 |
| 43 | Surfing the p53 network | Nature | 2000 | 6,411 |
| 44 | Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets | Cell | 2015 | 6,220 |
| 45 | Predicting effective microRNA target sites in mammalian mRNAs | ELife | 2015 | 6,037 |
| 46 | A robust and high-throughput Cre reporting and characterization system for the whole mouse brain | Nature Neuroscience | 2010 | 5,988 |
| 47 | Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death | Cell | 1993 | 5,891 |
| 48 | Integrative analysis of 111 reference human epigenomes | Nature | 2015 | 5,866 |
| 49 | Ultrasensitive fluorescent proteins for imaging neuronal activity | Nature | 2013 | 5,795 |
| 50 | THE GREEN FLUORESCENT PROTEIN | Annual Review of Biochemistry | 1998 | 5,717 |
