| # | Title | Journal | Year | Citations |
|---|
| 1 | Weaning from mechanical ventilation | European Respiratory Journal | 2007 | 1,962 |
| 2 | Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency | New England Journal of Medicine | 2009 | 1,633 |
| 3 | Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study Of Liver Diseases and the European Association for the Study of the Liver | Hepatology | 2014 | 1,498 |
| 4 | Definitions and Diagnosis of Pulmonary Hypertension | Journal of the American College of Cardiology | 2013 | 1,467 |
| 5 | Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia | New England Journal of Medicine | 2013 | 1,284 |
| 6 | Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic–Uremic Syndrome | New England Journal of Medicine | 2013 | 1,258 |
| 7 | Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440 | Environmental Microbiology | 2002 | 1,218 |
| 8 | Riociguat for the Treatment of Chronic Thromboembolic Pulmonary Hypertension | New England Journal of Medicine | 2013 | 1,144 |
| 9 | Evolution of Mechanical Ventilation in Response to Clinical Research | American Journal of Respiratory and Critical Care Medicine | 2008 | 1,133 |
| 10 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
| 11 | Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients | Journal of Clinical Investigation | 2008 | 1,069 |
| 12 | The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria | Allergy: European Journal of Allergy and Clinical Immunology | 2018 | 1,008 |
| 13 | Chronic Thromboembolic Pulmonary Hypertension (CTEPH) | Circulation | 2011 | 860 |
| 14 | Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) | European Journal of Immunology | 2019 | 766 |
| 15 | Olmesartan for the Delay or Prevention of Microalbuminuria in Type 2 Diabetes | New England Journal of Medicine | 2011 | 741 |
| 16 | A Cathepsin D-Cleaved 16 kDa Form of Prolactin Mediates Postpartum Cardiomyopathy | Cell | 2007 | 736 |
| 17 | The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres | Human Reproduction | 2012 | 732 |
| 18 | Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes | American Journal of Human Genetics | 2019 | 711 |
| 19 | Banff ’09 Meeting Report: Antibody Mediated Graft Deterioration and Implementation of Banff Working Groups | American Journal of Transplantation | 2010 | 691 |
| 20 | MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome | Journal of Neuroinflammation | 2016 | 686 |
| 21 | The human pattern of gyrification in the cerebral cortex | Anatomy and Embryology | 1988 | 654 |
| 22 | Fibroblast Growth Factor 23 (FGF23) Predicts Progression of Chronic Kidney Disease | Journal of the American Society of Nephrology: JASN | 2007 | 650 |
| 23 | Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma | Lancet, The | 1994 | 634 |
| 24 | Standardizing double-blind, placebo-controlled oral food challenges: American Academy of Allergy, Asthma & Immunology–European Academy of Allergy and Clinical Immunology PRACTALL consensus report | Journal of Allergy and Clinical Immunology | 2012 | 595 |
| 25 | Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients | Journal of Neuroinflammation | 2012 | 593 |
| 26 | MOG encephalomyelitis: international recommendations on diagnosis and antibody testing | Journal of Neuroinflammation | 2018 | 563 |
| 27 | The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4 | Nature Genetics | 2006 | 535 |
| 28 | The MLL recombinome of acute leukemias in 2017 | Leukemia | 2018 | 527 |
| 29 | Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism | Nature Genetics | 2013 | 519 |
| 30 | Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer | Nature Genetics | 2015 | 513 |
| 31 | Engaging neuroscience to advance translational research in brain barrier biology | Nature Reviews Neuroscience | 2011 | 508 |
| 32 | Complications of Right Heart Catheterization Procedures in Patients With Pulmonary Hypertension in Experienced Centers | Journal of the American College of Cardiology | 2006 | 498 |
| 33 | Education, income, and occupational class cannot be used interchangeably in social epidemiology. Empirical evidence against a common practice | Journal of Epidemiology and Community Health | 2006 | 498 |
| 34 | Update on the diagnosis and treatment of neuromyelitis optica: Recommendations of the Neuromyelitis Optica Study Group (NEMOS) | Journal of Neurology | 2014 | 494 |
| 35 | Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis | Nature Genetics | 2016 | 494 |
| 36 | Interferon- release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis | European Respiratory Journal | 2011 | 488 |
| 37 | Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial Hypertension | Circulation | 2013 | 482 |
| 38 | Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for theF508del-CFTRmutation | Thorax | 2012 | 466 |
| 39 | HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease) | Nature Genetics | 2007 | 450 |
| 40 | The risk of tuberculosis related to tumour necrosis factor antagonist therapies: a TBNET consensus statement | European Respiratory Journal | 2010 | 444 |
| 41 | Overall Survival in Patients With Advanced Melanoma Who Received Nivolumab Versus Investigator’s Choice Chemotherapy in CheckMate 037: A Randomized, Controlled, Open-Label Phase III Trial | Journal of Clinical Oncology | 2018 | 431 |
| 42 | Etiology, Management, and Outcome of the Budd-Chiari Syndrome | Annals of Internal Medicine | 2009 | 422 |
| 43 | Endothelial Dysfunction in Human Disease | Journal of Molecular and Cellular Cardiology | 1999 | 417 |
| 44 | Elevated endogenous cannabinoids in schizophrenia | NeuroReport | 1999 | 414 |
| 45 | Tezacaftor–Ivacaftor in Residual-Function Heterozygotes with Cystic Fibrosis | New England Journal of Medicine | 2017 | 412 |
| 46 | Side effects of retroviral gene transfer into hematopoietic stem cells | Blood | 2003 | 399 |
| 47 | A Randomized Trial of Lymphadenectomy in Patients with Advanced Ovarian Neoplasms | New England Journal of Medicine | 2019 | 373 |
| 48 | Safety and Efficacy of 1 Year of Tacrolimus Ointment Monotherapy in Adults With Atopic Dermatitis | Archives of Dermatology | 2000 | 368 |
| 49 | Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair | Nature Genetics | 2015 | 357 |
| 50 | Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer | Nature Genetics | 2017 | 356 |
