| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet, The | 2017 | 1,749 |
| 3 | Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation | Nature Cell Biology | 2018 | 1,650 |
| 4 | Modified Glomerular Filtration Rate Estimating Equation for Chinese Patients with Chronic Kidney Disease | Journal of the American Society of Nephrology: JASN | 2006 | 1,580 |
| 5 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
| 6 | Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility | Nature Genetics | 2014 | 959 |
| 7 | Mapping genomic loci implicates genes and synaptic biology in schizophrenia | Nature | 2022 | 929 |
| 8 | R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling | Cell | 2018 | 794 |
| 9 | Nivolumab versus chemotherapy in patients with advanced oesophageal squamous cell carcinoma refractory or intolerant to previous chemotherapy (ATTRACTION-3): a multicentre, randomised, open-label, phase 3 trial | Lancet Oncology, The | 2019 | 767 |
| 10 | Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Apatinib in Patients With Chemotherapy-Refractory Advanced or Metastatic Adenocarcinoma of the Stomach or Gastroesophageal Junction | Journal of Clinical Oncology | 2016 | 756 |
| 11 | METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification | Cell Stem Cell | 2018 | 749 |
| 12 | Groundwater Arsenic Contamination Throughout China | Science | 2013 | 731 |
| 13 | Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 | JAMA Oncology | 2022 | 719 |
| 14 | Investigating students’ perceived satisfaction, behavioral intention, and effectiveness of e-learning: A case study of the Blackboard system | Computers and Education | 2008 | 712 |
| 15 | TCM Database@Taiwan: The World's Largest Traditional Chinese Medicine Database for Drug Screening In Silico | PLoS ONE | 2011 | 677 |
| 16 | Identifying major depression using whole-brain functional connectivity: a multivariate pattern analysis | Brain | 2012 | 659 |
| 17 | Oral Probiotics Reduce the Incidence and Severity of Necrotizing Enterocolitis in Very Low Birth Weight Infants | Pediatrics | 2005 | 652 |
| 18 | Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity | Nature Communications | 2016 | 648 |
| 19 | Effect of Iodine Intake on Thyroid Diseases in China | New England Journal of Medicine | 2006 | 624 |
| 20 | Positive Correlations of Oct-4 and Nanog in Oral Cancer Stem-Like Cells and High-Grade Oral Squamous Cell Carcinoma | Clinical Cancer Research | 2008 | 592 |
| 21 | Mesenchymal Stem Cells | Cell Transplantation | 2011 | 589 |
| 22 | Investigating learners’ attitudes toward virtual reality learning environments: Based on a constructivist approach | Computers and Education | 2010 | 551 |
| 23 | Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians | Nature Genetics | 2012 | 545 |
| 24 | Deubiquitination and Stabilization of PD-L1 by CSN5 | Cancer Cell | 2016 | 538 |
| 25 | Outcomes at School Age after Postnatal Dexamethasone Therapy for Lung Disease of Prematurity | New England Journal of Medicine | 2004 | 527 |
| 26 | Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data | Lancet Respiratory Medicine,the | 2014 | 527 |
| 27 | Acute respiratory failure in COVID-19: is it “typical” ARDS? | Critical Care | 2020 | 517 |
| 28 | Energy Metabolism in Astrocytes: High Rate of Oxidative Metabolism and Spatiotemporal Dependence on Glycolysis/Glycogenolysis | Journal of Cerebral Blood Flow and Metabolism | 2007 | 516 |
| 29 | PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis | Nature Cell Biology | 2020 | 508 |
| 30 | Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer | Nature Genetics | 2013 | 493 |
| 31 | Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1 | Molecular Cell | 2018 | 491 |
| 32 | A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt | Liver International | 2011 | 481 |
| 33 | The effects of heavy metals on human metabolism | Toxicology Mechanisms and Methods | 2020 | 469 |
| 34 | Surveying instructor and learner attitudes toward e-learning | Computers and Education | 2007 | 467 |
| 35 | In vivo corrosion behavior of Mg-Mn-Zn alloy for bone implant application | Journal of Biomedical Materials Research - Part A | 2007 | 462 |
| 36 | In vitro and in vivo evaluation of the surface bioactivity of a calcium phosphate coated magnesium alloy | Biomaterials | 2009 | 454 |
| 37 | Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally | Nature | 2019 | 452 |
| 38 | Reduced default mode network functional connectivity in patients with recurrent major depressive disorder | Proceedings of the National Academy of Sciences of the United States of America | 2019 | 441 |
| 39 | Astrocytic control of glutamatergic activity: astrocytes as stars of the show | Trends in Neurosciences | 2004 | 433 |
| 40 | Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds | Antiviral Research | 2005 | 430 |
| 41 | Guidelines for the Diagnosis and Treatment of Hepatocellular Carcinoma (2019 Edition) | Liver Cancer | 2020 | 427 |
| 42 | Guidelines for Diagnosis and Treatment of Primary Liver Cancer in China (2017 Edition) | Liver Cancer | 2018 | 426 |
| 43 | Standards of medical care for type 2 diabetes in China 2019 | Diabetes/Metabolism Research and Reviews | 2019 | 404 |
| 44 | Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction | Antiviral Research | 2007 | 400 |
| 45 | PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma | Oncotarget | 2016 | 400 |
| 46 | p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease | Nephrology Dialysis Transplantation | 2011 | 390 |
| 47 | Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial | Lancet Oncology, The | 2012 | 390 |
| 48 | Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion | Cancer Cell | 2020 | 389 |
| 49 | Conversion of Human Umbilical Cord Mesenchymal Stem Cells in Wharton's Jelly to Dopaminergic Neurons In Vitro: Potential Therapeutic Application for Parkinsonism | Stem Cells | 2006 | 384 |
| 50 | 6-Alkylamino- and 2,3-Dihydro-3‘-methoxy-2-phenyl-4-quinazolinones and Related Compounds: Their Synthesis, Cytotoxicity, and Inhibition of Tubulin Polymerization | Journal of Medicinal Chemistry | 2000 | 376 |
